CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11262
Family Name Angiotensin-converting enzyme inhibitor (2S)-2-[[(3R)-5-(carboxymethyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-3-yl]amino]-4-phenylbutanoic acid family
No. of Seeds 6 No. of Other Members 4
Family Centroid CFAMM00407934 Functional Category Bioactive
Superfamily Prelamin-A/C and Lethal factor Binder Superfamily 8
Class Class 4812

Cousin Family NamesSeedsMembers
Penicillin binding protein inhibitor β-lactam aminopenicillin ... 12 359
Angiotensin-converting enzyme Inhibitor Benazepril Family 7 123
Angiotensin-converting enzyme Inhibitor Quinapril Family 3 105
Angiotensin-converting enzyme Inhibitor Spirapril Family 17 86
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 7 54
Angiotensin-converting enzyme Inhibitor Temocapril Family 4 15
Angiotensin-converting enzyme and Neprilysin Inhibitor M100,24... 18 60
Dopamine reuptake Inhibitor Amineptine Family 2 5
Integrin alpha-4 Inhibitor BIO-1211 Family 16 83
Neprilysin Inhibitor Thiorphan Family 41 68
Farnesyltransferase beta subunit, putative and Protein farnesy... 24 82
Cholecystokinin receptor type A Ligand VL-1499 Family 12 133
Protein kinase C eta type and Protein kinase C delta type Inhi... 9 12
Cathepsin B and Cathepsin S Inhibitor Ac-hphe-leu-ala-leuvsme ... 17 51
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
5-hydroxytryptamine receptor 2A Ligand Cinanserin Family 3 27
DNA (cytosine-5)-methyltransferase 3B Inhibitor NSC-154957 Family 2 3
Genome polyprotein Inhibitor Acdif-ile-cha-cys Family 37 96
Leukotriene A-4 hydrolase Inhibitor SA-6541 Family 4 32
Prothrombin and Plasminogen inhibitor [(1R)-5-amino-1-[[2-[N-(... 1 0
Protein farnesyltransferase subunit beta and Protein farnesylt... 3 5
Growth hormone secretagogue receptor type 1 ligand (2R)-N-(2-a... 2 8
Mitogen-activated protein kinase 1 and M17 leucyl aminopeptida... 1 21
Thyroid hormone receptor beta ligand CHEMBL1473810 family 1 5
Dipeptidyl peptidase 4 inhibitor SureCN1499864 family 4 7
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-1-... 3 3
Sodium channel protein type 9 subunit alpha ligand tert-butyl ... 2 30
fMet-Leu-Phe receptor ligand (2S)-2-[[(2S)-2-[[(2S)-2-[(4-chlo... 1 0
Growth hormone secretagogue receptor type 1 ligand 2-amino-2-m... 4 2
Growth hormone secretagogue receptor type 1 ligand SureCN77944... 1 2
Granzyme B and Caspase-3 inhibitor CHEMBL304368 family 2 1
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 11 4
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 2 5
Angiotensin-converting enzyme inhibitor 89177-63-9 family 2 0
Neprilysin and Angiotensin-converting enzyme inhibitor 3-[(3S)... 1 0


External ID

Functional Category

Molecule Name

CFAMM00407934 CHEMBL2114418 Bioactive (2S)-2-[[(3R)-5-(carboxymethyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-3-yl]amino]-4-phenylbutanoic acid
CFAMM00407940 CHEMBL38613 Bioactive SureCN10345405
CFAMM00407939 CHEMBL36748 Bioactive 2-[[(3R)-5-(carboxymethyl)-1,4-dioxo-2,3-dihydro-1$l^{4},5-benzothiazepin-3-yl]amino]-4-phenylbutanoic acid
CFAMM00407937 CHEMBL290284 Bioactive SureCN11070276

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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