CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11282
Family Name Pol polyprotein inhibitor AC1LAHRX family
No. of Seeds 4 No. of Other Members 0
Family Centroid CFAMM00408087 Functional Category Bioactive
Superfamily Prothrombin and Pol polyprotein Binder Superfamily 2
Class Class 85

Cousin Family NamesSeedsMembers
HIV protease Inhibitor Indinavir Family 36 211
HIV-1 protease Inhibitor Atazanavir Family 16 58
Cathepsin B and Cathepsin K Inhibitor Z-arg-leu-val-agly-ile-v... 3 19
Delta-type opioid receptor Ligand H-poa-ser-gly-phe-leu-thr-oh... 5 12
Renin inhibitor (2S,4S,5S)-6-cyclohexyl-4-hydroxy-5-[[(2S)-2-[... 3 0
Pol polyprotein inhibitor AC1LAD48 family 19 5
Beta-3 adrenergic receptor and Beta-2 adrenergic receptor liga... 19 53
Pol polyprotein inhibitor pyridin-2-ylmethyl N-[(2R)-1-[[(2S,3... 15 8
Plasmepsin-1 and Plasmepsin-2 inhibitor Statine-like inhibitor... 13 5
Neutrophil elastase inhibitor SureCN7284457 family 4 6
Pol polyprotein inhibitor Carbamic acid, ((2-hydroxy-1,4-bis(p... 21 1
Calpain-2 catalytic subunit and Calpain-1 catalytic subunit in... 8 8
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 5 2
Cruzipain and Cathepsin L1 inhibitor pyridin-3-ylmethyl N-[(2S... 7 4
Pol polyprotein inhibitor (2S,4S,5S)-5-acetamido-6-cyclohexyl-... 3 3
Integrin beta-3 and Integrin alpha-V inhibitor (2S)-3-[5-methy... 4 5
Beta-secretase 1 inhibitor (2S)-2-[(3S)-3-acetamido-3-butan-2-... 4 4
Histone deacetylase 2 and Histone deacetylase 1 inhibitor 9H-f... 1 7
Pol polyprotein inhibitor AC1LAHQ9 family 8 15
Cathepsin K and Cathepsin S inhibitor dipeptidyl nitrile, 16b ... 2 0
Renin inhibitor tert-butyl N-[1-[[1-[[(2S,3S)-1-cyclohexyl-3-h... 1 0
Beta-secretase 1 and Cathepsin B inhibitor SureCN14347937 family 4 1
Integrin beta-3 and Integrin alpha-IIb inhibitor SureCN7013744... 2 3
Renin inhibitor tert-butyl N-[1-[[1-[[1-cyclohexyl-4,4-difluor... 5 0
Renin and Cathepsin D inhibitor (4S)-5-cyclohexyl-2,2-difluoro... 4 1
Pol polyprotein inhibitor [(2R,3R)-1,1-dioxo-2-propan-2-ylthio... 11 0
Beta-secretase 1 and Cathepsin B inhibitor SureCN14347784 family 4 0
Beta-3 adrenergic receptor ligand N-[4-[2-[[(2R)-2-hydroxy-2-p... 4 10
Nicotinamide phosphoribosyltransferase inhibitor pyridin-3-ylm... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00408088 CHEMBL377192 Bioactive AC1LAHSC
CFAMM00408087 CHEMBL211715 Bioactive AC1LAHRX
CFAMM00408086 CHEMBL384210 Bioactive AC1LAHSF
CFAMM00408085 CHEMBL351994 Bioactive pyridin-2-ylmethyl N-[(2S)-4-amino-1-[[(2S,3R)-4-[benzenesulfonyl(3-methylbutyl)amino]-3-hydroxy-1-phenylbutan-2-yl]amino]-1,4-dioxobutan-2-yl]carbamate

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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