CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11285
Family Name Melanin-concentrating hormone receptor 1 and Cytochrome P450 2D6 ligand 4-(4-ethylphenyl)-N-methyl-N-[(3S)-1-[(3R)-3-piperidin-1-ylpyrrolidine-1-carbonyl]pyrrolidin-3-yl]benzamide family
No. of Seeds 3 No. of Other Members 4
Family Centroid CFAMM00408100 Functional Category Bioactive
Superfamily Kappa-type opioid receptor and C-C chemokine receptor type 5 Binder Superfamily
Class Class 1062

Cousin Family NamesSeedsMembers
Mu-type opioid receptor Ligand Fentanyl Family 9 647
5-hydroxytryptamine receptor 3A Ligand Palonosetron Family 12 403
Glutathione S-transferase Inhibitor Praziquantel Family 5 167
Noradrenergic re-uptake and Serotonin re-uptake Inhibitor Diet... 29 276
DNA Binder Procarbazine Family 8 358
Microsomal triglyceride transfer protein large subunit Inhibit... 15 208
Substance-K receptor and Substance-P receptor Ligand DNK-333 F... 15 95
Bavisant family 9 65
Neuropeptide Y receptor type 1 Ligand BIBO3304 Family 4 69
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 11 67
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Dipeptidyl peptidase 4 Inhibitor Denagliptin Family 24 151
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Neutrophil elastase Inhibitor FK-706 Family 8 85
Neutrophil elastase Inhibitor Ici 200,355 Family 9 20
Poly(ADP-ribose) glycohydrolase Inhibitor N-bis-(3-phenyl-prop... 3 7
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-m... 8 37
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
Plasmepsin-2 Inhibitor PS-222036 Family 12 134
Farnesyltransferase beta subunit, putative and Protein farnesy... 6 3
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Tic... 11 31
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 41 24
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 3 21
Sodium-dependent dopamine transporter and Sodium-dependent nor... 28 71
Cannabinoid receptor 1 Ligand N-(3,3-diphenyl)propyl-2-phenyla... 4 18
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 20 55
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 44 28
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 9 66
Arachidonate 5-lipoxygenase Inhibitor N-hydroxy-n-methyl-benza... 3 9
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 2 80
5-hydroxytryptamine receptor 2A Ligand N-(1-(3-bromobenzyl)pip... 6 10
Prolyl endopeptidase Inhibitor SUAM-1221 Family 42 47
Voltage-dependent calcium channel gamma-1 subunit Ligand NP-11... 8 9
Substance-P receptor ligand AGN-PC-00FJ8P family 6 10
Disintegrin and metalloproteinase domain-containing protein 17... 3 2
Substance-K receptor ligand 4-(4-methylphenyl)-N-[1-[[(2S)-5-[... 6 0
Vasopressin V1a receptor and Vasopressin V2 receptor ligand [2... 2 4
Disintegrin and metalloproteinase domain-containing protein 17... 4 1
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 2 7
C-C chemokine receptor type 5 ligand AC1L9USC family 3 2
Kappa-type opioid receptor ligand 6-[2-oxo-2-[(2S)-2-(pyrrolid... 6 4
Kappa-type opioid receptor ligand 1-[(2S)-2-(pyrrolidin-1-ylme... 4 0
Histamine H3 receptor ligand 1-(4-pentan-3-ylpiperazin-1-yl)-2... 3 1
Growth hormone secretagogue receptor type 1 ligand (E)-5-amino... 2 2
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 3 0
Prolyl endopeptidase inhibitor (2R)-1-[(2S)-1-[3-[(2R)-2-acety... 15 9
Acetylcholinesterase inhibitor 5-benzoyl-2-[2-(1-benzylpiperid... 2 3
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075BLN ... 2 1
Dipeptidyl peptidase 8 inhibitor (2S)-2-amino-4-[4-[bis(4-fluo... 2 9
Melanin-concentrating hormone receptor 1 ligand (3S)-3-[[5-(4-... 15 16
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075C6K ... 3 22
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 3 0
Substance-P receptor ligand (3S,4S)-N-[[3,5-bis(trifluoromethy... 8 9
Oxytocin receptor and Vasopressin V2 receptor ligand (2R)-2-(2... 4 2
Dipeptidyl peptidase 2 and Dipeptidyl peptidase 4 inhibitor (2... 3 10
Histamine H3 receptor and Potassium voltage-gated channel subf... 9 0
Dipeptidyl peptidase 4 inhibitor 4-cyano-N-[4-[(2S)-2-cyanopyr... 1 1
Microsomal triglyceride transfer protein large subunit inhibit... 8 1
Melanin-concentrating hormone receptor 1 ligand N-methyl-4-(4-... 1 0
P2X purinoceptor 7 inhibitor SureCN8516206 family 5 1
Muscarinic acetylcholine receptor M3 and Muscarinic receptor 3... 3 0
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 3 1
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(4... 5 1
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 3 1
Follicle-stimulating hormone receptor ligand N-[[3-[4-[[(2S,5S... 7 0
Prothrombin inhibitor N-[7-amino-1-[2-(4-carbamoylphenyl)ethyl... 8 1
Kappa-type opioid receptor ligand SureCN5629426 family 3 2
Plasmepsin-2 inhibitor SureCN8292428 family 1 2
Melanocortin receptor 4 and Melanocortin receptor 3 ligand (2S... 2 0
Prolyl endopeptidase inhibitor 2-{3-[(2s)-4,4-Difluoro-2-(Pyrr... 2 2
C-C chemokine receptor type 2 ligand AGN-PC-03L0Z6 family 1 1
C-C chemokine receptor type 5 ligand N-benzyl-N-[(3R)-1-[(1S,5... 1 3
Phospholipase D1 and Phospholipase D2 inhibitor N-[(2S)-1-[4-(... 3 5
Muscarinic acetylcholine receptor M3 ligand N-[[4-fluoro-3-[3-... 3 0
Cathepsin S and Cathepsin L1 inhibitor (Z,3S)-1-diazonio-3-[[2... 1 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
Muscarinic acetylcholine receptor M2 ligand 3-[(1Z)-1-benzylid... 2 0
Lethal(3)malignant brain tumor-like protein 3 and Lethal(3)mal... 1 0
Lethal(3)malignant brain tumor-like protein 3 and Lethal(3)mal... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00408103 CHEMBL214126 Bioactive 4-(4-ethylphenyl)-N-methyl-N-[(3S)-1-[(3R)-3-(oxan-4-ylamino)pyrrolidine-1-carbonyl]pyrrolidin-3-yl]benzamide
CFAMM00408101 CHEMBL211746 Bioactive N-methyl-N-[(3S)-1-[(3R)-3-(3-phenylpropylamino)pyrrolidine-1-carbonyl]pyrrolidin-3-yl]-4-[4-(trifluoromethyl)phenyl]benzamide
CFAMM00408100 CHEMBL214660 Bioactive 4-(4-ethylphenyl)-N-methyl-N-[(3S)-1-[(3R)-3-piperidin-1-ylpyrrolidine-1-carbonyl]pyrrolidin-3-yl]benzamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27511 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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