CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11292
Family Name Muscarinic acetylcholine receptor M3 and Muscarinic acetylcholine receptor M4 ligand SureCN6628105 family
No. of Seeds 13 No. of Other Members 3
Family Centroid CFAMM00408123 Functional Category Bioactive
Superfamily Beta-secretase 1 and Muscarinic acetylcholine receptor M3 Binder Superfamily
Class Class 1444

Cousin Family NamesSeedsMembers
Vasopressin V1a receptor Ligand Felypressin Family 12 820
Bacterial outer membrane Inhibitor Polymyxin B Family 17 181
Kappa-type opioid receptor Ligand Asimadoline Family 14 54
Dipeptidyl peptidase 4 Inhibitor Denagliptin Family 24 151
Renin Inhibitor CP-80794 Family 16 112
Neuromedin-K receptor Ligand Senktide Family 15 22
Cathepsin F and Cruzipain Inhibitor WRR-99 Family 13 131
Beta-secretase 1 Inhibitor MMI-175 Family 30 137
Disintegrin and metalloproteinase domain-containing protein 17... 8 7
Plasmepsin-2 Inhibitor PS-222036 Family 12 134
Plasmepsin-1 Inhibitor SC-5003 Family 93 173
Neuromedin-K receptor Ligand PD-160946 Family 10 32
Nociceptin receptor Ligand Fggftgcrkscrk Family 10 0
Beta-secretase 1 Inhibitor Glu-leu-asp-leu-(choh-ch2)-ala-ala-... 15 11
Calcitonin gene-related peptide type 1 receptor Ligand Fvptdvg... 8 8
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Tic... 11 31
Melanocortin receptor 4 and Substance-K receptor Ligand Hoo-ph... 3 19
Beta-secretase 1 Inhibitor KMI-172 Family 3 0
Integrin alpha-V Inhibitor C[rgdf-(3s)-carboxymorpholine] Family 10 2
Caspase-4 and Cathepsin D Inhibitor Grassystatin A Family 24 6
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 44 28
Genome polyprotein Inhibitor Acasp-glu-cha-val-prb-cys Family 13 18
Prolyl endopeptidase Inhibitor SUAM-1221 Family 42 47
Mu-type opioid receptor and Nociceptin receptor Ligand Nocicep... 35 5
Renin inhibitor (2S,4S,5S)-N-butyl-6-cyclohexyl-4-hydroxy-5-[[... 12 1
Renin inhibitor (2S,4S,5S)-N-(4-aminobutyl)-6-cyclohexyl-4-hyd... 32 2
Renin inhibitor (2S,4S,5S)-N-[3-[[amino-(cyanoamino)methyliden... 7 0
Pol polyprotein inhibitor penicillin deriv. 69 family 1 1
Beta-secretase 1 and Cathepsin D inhibitor (1R,3S)-N-[(2S,3S)-... 2 25
Pol polyprotein inhibitor benzyl N-[(2S)-1-[[(2S,3S,4R,5S)-3,4... 21 5
Renin and Cathepsin D inhibitor (2S)-N-[(2S,3R,4S)-1-cyclohexy... 13 2
Pol polyprotein inhibitor (2S)-4-benzyl-1-[(2S,4R)-4-benzyl-2-... 10 4
Baculoviral IAP repeat-containing protein 2 and Baculoviral IA... 2 2
Cathepsin B and Calpain-2 catalytic subunit inhibitor AGN-PC-0... 2 2
Renin and Cathepsin D inhibitor (3S)-4-[[6-acetamido-2-[[3-nap... 6 26
Renin inhibitor [(2R)-1-[[(2S,3S,5R)-6-(butylamino)-1-cyclohex... 5 4
Melanocortin receptor 4 and Melanocortin receptor 5 ligand (2S... 16 24
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 3 0
Renin and Cathepsin D inhibitor (4S)-5-cyclohexyl-2,2-difluoro... 16 1
Endothelin-converting enzyme 1 and Cathepsin D inhibitor N-[(2... 6 2
Kappa-type opioid receptor and Delta-type opioid receptor liga... 9 0
Beta-secretase 1 inhibitor (2S)-2-[(3S)-3-acetamido-3-butan-2-... 3 3
Beta-secretase 1 inhibitor (2S)-2-[(3R)-3-acetamido-3-(2-methy... 3 0
Beta-secretase 1 inhibitor (2S)-2-[(3S)-3-acetamido-3-butan-2-... 6 11
Beta-secretase 1 inhibitor (2S)-2-[(3S)-3-acetamido-3-butan-2-... 4 6
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 3 0
Beta-secretase 1 and Cathepsin D inhibitor (4S)-N-[(2S,3R)-4-[... 3 0
Renin and Cathepsin D inhibitor N-[(2S)-1-[[(2S)-1-[[(2S)-1-cy... 2 0
Pol polyprotein inhibitor AC1L9R8I family 1 0
Pol polyprotein inhibitor Diol-Based HIV-1 protease inhibitor ... 1 0
Pol polyprotein inhibitor AC1LACBC family 2 0
Histamine H3 receptor ligand Conessine analogue, 13e family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00408121 CHEMBL212645 Bioactive SureCN4578800
CFAMM00408127 CHEMBL215189 Bioactive SureCN4599015
CFAMM00408120 CHEMBL215180 Bioactive SureCN4579250
CFAMM00408124 CHEMBL378885 Bioactive SureCN4579755
CFAMM00408123 CHEMBL214029 Bioactive SureCN6628105
CFAMM00408129 CHEMBL378772 Bioactive (2R)-N-[[1-(cyclopropylmethyl)piperidin-4-yl]methyl]-1-[(2S,4R)-4-hydroxy-1-[3,3,3-tris(4-fluorophenyl)propanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carboxamide
CFAMM00408122 CHEMBL214898 Bioactive SureCN6827340

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

43312 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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