CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11298
Family Name Tyrosine-protein kinase Lck and Vascular endothelial growth factor receptor 2 ligand AGN-PC-00SRAA family
No. of Seeds 3 No. of Other Members 0
Family Centroid CFAMM00172752 Functional Category Bioactive
Superfamily Bacterial outer membrane Inhibitor HKI-9924129 Superfamily
Class Class 1053

Cousin Family NamesSeedsMembers
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Prothrombin Inhibitor Dabigatran Family 7 182
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 5 129
Transient receptor potential cation channel subfamily V member... 16 295
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Vascular endothelial growth factor receptor 1 and Angiopoietin... 29 127
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
JAK Inhibitor Momelotinib Family 33 83
XL-888 family 16 85
Platelet activating factor, putative Inhibitor ABT-491 Family 22 62
Bacterial outer membrane Inhibitor HKI-9924129 Family 19 85
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
Epidermal growth factor receptor and Receptor tyrosine-protein... 11 138
Cyclin-dependent kinase 4 Inhibitor 1-(9-oxo-9h-fluoren-4-yl)-... 3 5
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 93
Epidermal growth factor receptor Ligand N4-(3-chlorophenyl)qui... 7 39
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Adenosine receptor A3 Ligand 1-(2-(diethylamino)quinazolin-4-y... 2 9
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Adenosine receptor A1 Ligand N-(4,6-diphenylpyrimidin-2-yl)ben... 4 8
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Peroxisome proliferator-activated receptor gamma Ligand 2-chlo... 5 19
Bifunctional epoxide hydrolase 2 Inhibitor 6-amino-n-(2,4-dich... 10 116
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Serine/threonine-protein kinase B-raf Inhibitor Pyrazolo[1,5-a... 7 77
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 1 3
Adenosine receptor A2a and Adenosine receptor A1 ligand 2-amin... 10 48
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 12
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 2 4
Tyrosine-protein kinase ABL1 and Mitogen-activated protein kin... 1 3
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 6 9
Cathepsin K and Potassium voltage-gated channel subfamily H me... 4 7
Coagulation factor X inhibitor AGN-PC-075AY8 family 28 21
Cell division cycle 7-related protein kinase and Cyclin-depend... 2 9
Adenosine receptor A3 ligand N-(5-methyl-2-phenylpyrazolo[4,3-... 5 8
Mitogen-activated protein kinase 1 and Cytochrome P450 3A4 inh... 1 0
Peroxisome proliferator-activated receptor gamma ligand 1-[(4-... 7 29
Metabotropic glutamate receptor 2 ligand AGN-PC-09QJ9P family 2 7
Microsomal triglyceride transfer protein large subunit inhibit... 7 4
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 0
Dihydrofolate reductase inhibitor 1-[3-(2,4-diaminoquinazolin-... 2 4
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 3 0
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 14 2
Mitogen-activated protein kinase 14 inhibitor SureCN3305171 fa... 1 0
Transient receptor potential cation channel subfamily V member... 2 1
Hepatocyte growth factor receptor ligand 5-[[6-(1-methylpyrazo... 4 0
Hepatocyte growth factor receptor ligand 5-[(6-phenyl-[1,2,4]t... 6 2
Mast/stem cell growth factor receptor Kit and Mitogen-activate... 4 2
Substance-P receptor ligand 2-[3,5-bis(trifluoromethyl)phenyl]... 3 1
Glycogen synthase kinase-3 beta inhibitor N-[2-[4-(ethylsulfon... 3 1
Aurora kinase A and Aurora kinase B inhibitor 4-fluoro-N-[4-[(... 6 1
Melanin-concentrating hormone receptor 1 ligand 6-(4-chlorophe... 8 1
Succinate receptor 1 ligand N-[[4-(3-methylphenyl)phenyl]methy... 2 14
Eukaryotic translation initiation factor 2-alpha kinase 3 inhi... 11 2
Tyrosine-protein kinase JAK2 inhibitor N-[3-(3-chlorophenyl)-1... 12 4
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 12 0
P2X purinoceptor 7 inhibitor SureCN109432 family 10 28
P2X purinoceptor 7 inhibitor SureCN109149 family 8 1
P2X purinoceptor 7 inhibitor SureCN113576 family 2 1
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 2
Epithelial discoidin domain-containing receptor 1 and Mast/ste... 1 0
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor (3R)-... 4 12
Non-receptor tyrosine-protein kinase TYK2 ligand AGN-PC-0D0YSZ... 10 0
Non-receptor tyrosine-protein kinase TYK2 ligand SureCN1298914... 3 0
Eukaryotic translation initiation factor 2-alpha kinase 3 and ... 4 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 4-[4... 1 1
RAF proto-oncogene serine/threonine-protein kinase and Serine/... 4 3
Coagulation factor X inhibitor AGN-PC-078Y0S family 7 1
Mitogen-activated protein kinase 14 inhibitor 3-[(6-amino-1-ph... 9 2
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 3 0
Coagulation factor X inhibitor AGN-PC-078Y0T family 11 0
Serine/threonine-protein kinase B-raf inhibitor 1-[2-[[4-[2-cy... 2 0
Proto-oncogene tyrosine-protein kinase Src and Fibroblast grow... 3 4
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Epidermal growth factor receptor ligand (E)-1-[4-(3-bromoanili... 9 0
Macrophage colony-stimulating factor 1 receptor ligand AGN-PC-... 3 0
P2X purinoceptor 7 inhibitor N-[1-[(Z)-[(cyanoamino)-(quinolin... 3 3
Mast/stem cell growth factor receptor Kit and Tyrosine-protein... 4 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and Potassium ... 1 0
Sonic hedgehog protein and Cytochrome P450 2C9 inhibitor AGN-P... 1 0
Cannabinoid receptor 1 ligand AGN-PC-07R6O8 family 5 2
Dihydrofolate reductase inhibitor N-(2,4-diamino-5-methylquina... 2 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-[(2,6... 1 1
Transcription factor AP-1 and Nuclear factor NF-kappa-B p105 s... 2 4
Corticotropin-releasing factor receptor 2 and Corticotropin-re... 2 1
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00408172 CHEMBL212900 Bioactive AGN-PC-00E2JU

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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