CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1131
Family Name Prothrombin inhibitor N-[(2S)-3-[(3S)-1-carbamimidoylpiperidin-3-yl]-1-oxo-1-(1,3-thiazol-2-yl)propan-2-yl]-2-[(2R)-2-[(2-chlorophenyl)methyl]-3,6-dioxo-4-(3-phenylpropyl)piperazin-1-yl]acetamide family
No. of Seeds 4 No. of Other Members 10
Family Centroid CFAMM00319792 Functional Category Bioactive
Superfamily Prothrombin and Trypsin-1 Binder Superfamily 2
Class Class 2352

Cousin Family NamesSeedsMembers
Tubulin beta chain Inhibitor DOLASTATIN-10 Family 4 93
Coagulation factor X Inhibitor Phso2-gly-(me-gly)-arg-(2-thiaz... 32 62
Fatty-acid amide hydrolase 1 Inhibitor 7-phenyl-1-(thiazol-2-y... 4 5
Prothrombin inhibitor (3R,6R,8aS)-N-[5-(diaminomethylideneamin... 4 1
Prothrombin inhibitor (6S,8aS)-N-[5-(diaminomethylideneamino)-... 12 10
Coagulation factor XI and Prothrombin inhibitor alpha-ketothia... 5 2
Cationic trypsin and Prothrombin inhibitor benzyl N-[(2R)-1-[(... 2 6
Prothrombin and Cationic trypsin inhibitor (2S)-1-[(2R)-2-amin... 1 0
Coagulation factor X and Prothrombin inhibitor (2S)-2-(benzyls... 4 4
Coagulation factor X and Prothrombin inhibitor AGN-PC-0754DR f... 2 2
Coagulation factor X and Prothrombin inhibitor 2-[(3S)-3-benzy... 7 0
Coagulation factor X and Prothrombin inhibitor N-[5-(diaminome... 2 0
Prothrombin inhibitor (3R,6S,8aS)-N-[5-(diaminomethylideneamin... 2 3
Coagulation factor X and Prothrombin inhibitor SureCN7377461 f... 4 0
Coagulation factor X and Prothrombin inhibitor 2-[4-(5-chloron... 3 0
Prothrombin and Trypsin-1 inhibitor 2-[(2S)-4-benzyl-2-(naphth... 1 0


External ID

Functional Category

Molecule Name

CFAMM00319792 CHEMBL402378 Bioactive N-[(2S)-3-[(3S)-1-carbamimidoylpiperidin-3-yl]-1-oxo-1-(1,3-thiazol-2-yl)propan-2-yl]-2-[(2R)-2-[(2-chlorophenyl)methyl]-3,6-dioxo-4-(3-phenylpropyl)piperazin-1-yl]acetamide
CFAMM00319789 CHEMBL111646 Bioactive (6S,8aS)-N-[5-(diaminomethylideneamino)-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]-2-[3-(3,4-dichlorophenyl)propanoyl]-4-oxo-1,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-6-carboxamide
CFAMM00319794 CHEMBL83260 Bioactive N-[(2S)-3-(1-carbamimidoylpiperidin-3-yl)-1-oxo-1-(1,3-thiazol-2-yl)propan-2-yl]-2-[(2R)-2-[(2-chlorophenyl)methyl]-3,6-dioxo-4-(3-phenylpropyl)piperazin-1-yl]acetamide
CFAMM00319787 CHEMBL313769 Bioactive N-[(2S)-3-(1-carbamimidoylpiperidin-3-yl)-1-oxo-1-(1,3-thiazol-2-yl)propan-2-yl]-2-[(2R)-2-[(3,4-dichlorophenyl)methyl]-3,6-dioxo-4-(3-phenylpropyl)piperazin-1-yl]acetamide

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

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Professor in Department of Pharmacy
National University of Singapore, Singapore

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