CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1132
Family Name Corticotropin-releasing factor receptor 1 ligand AGN-PC-074YT9 family
No. of Seeds 28 No. of Other Members 20
Family Centroid CFAMM00319819 Functional Category Bioactive
Superfamily Corticotropin-releasing factor receptor 1 and Smoothened homolog Binder Superfamily
Class Class 1034

Cousin Family NamesSeedsMembers
Histamine H1 receptor ligand tricyclic antidepressant Deslorat... 6 136
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
C-reactive protein Inhibitor ISIS-CRP Family 4 105
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
Corticotropin-releasing factor receptor 1 Ligand Dmp-695/696 F... 11 20
D(4) dopamine receptor Ligand Fauc 113 Family 14 96
Prothrombin Inhibitor 4-[3-(4-chlorophenyl)-1h-pyrazol-5-yl]pi... 7 39
TGF-beta receptor type-1 Ligand 4-(3-pyridin-2-yl-1h-pyrazol-4... 3 63
TGF-beta receptor type-1 Ligand Naphthyridine Inhibitor Family 3 6
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
D(2) dopamine receptor and D(3) dopamine receptor Ligand 1-(4-... 10 48
Calcium-activated potassium channel subunit alpha-1 Ligand 1-(... 3 3
Glycogen synthase kinase-3 beta Inhibitor CHIR-98023 Family 5 6
Indoleamine 2,3-dioxygenase 1 Inhibitor 4-(1h-1,2,3-triazol-5-... 3 12
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 3 63
Histamine H3 receptor and Potassium voltage-gated channel subf... 2 2
Histamine H3 receptor and Potassium voltage-gated channel subf... 4 33
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 2
Corticotropin-releasing factor receptor 1 ligand 3,7-dimethyl-... 3 4
Corticotropin-releasing factor receptor 1 ligand AGN-PC-074YUB... 2 0
Smoothened homolog inhibitor AC1P6IWE family 1 0
Survival motor neuron protein and Nuclear receptor ROR-gamma l... 1 2
Cannabinoid receptor 2 ligand 8-(2-chlorophenyl)-9-cyclopropyl... 4 5
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 2-[8-... 2 5
D(4) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-[1-... 5 3
Receptor-type tyrosine-protein kinase FLT3 and Aurora kinase A... 2 0
Corticotropin-releasing factor receptor 1 ligand AGN-PC-01Z2AT... 1 10
Corticotropin-releasing factor receptor 1 ligand SureCN7215846... 4 1
Cannabinoid receptor 1 ligand AGN-PC-07NHJ5 family 9 1
Adenosine receptor A1 ligand 3-[(2-chlorophenyl)methyl]-N-cycl... 1 1
Serine/threonine-protein kinase B-raf and Mitogen-activated pr... 16 5
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 3 22
Cannabinoid receptor 1 ligand AGN-PC-07CPJ5 family 9 14
TGF-beta receptor type-1 ligand 6-bromo-4-(2-(6-methylpyridin-... 1 3


External ID

Functional Category

Molecule Name

CFAMM00319812 CHEMBL325051 Bioactive AGN-PC-074YSO
CFAMM00319838 CHEMBL445075 Bioactive N-(cyclopropylmethyl)-3-(2,4-dichlorophenyl)-1,5-dimethyl-N-propylpyrazolo[4,3-b]pyridin-7-amine
CFAMM00319805 CHEMBL112057 Bioactive AGN-PC-074YTL
CFAMM00319818 CHEMBL114861 Bioactive AGN-PC-074YNA
CFAMM00319811 CHEMBL112336 Bioactive AGN-PC-074YSX
CFAMM00319824 CHEMBL334039 Bioactive SureCN6831521
CFAMM00319837 CHEMBL112560 Bioactive AGN-PC-074YSU
CFAMM00319804 CHEMBL114193 Bioactive 3-(2,4-dichlorophenyl)-1,5-dimethyl-N,N-dipropylpyrazolo[4,3-b]pyridin-7-amine
CFAMM00319830 CHEMBL326284 Bioactive AGN-PC-074YPL
CFAMM00319797 CHEMBL322969 Bioactive N-butyl-3-(2,4-dichlorophenyl)-N,1-diethyl-5-methylpyrazolo[4,3-b]pyridin-7-amine
CFAMM00319810 CHEMBL114912 Bioactive N-butyl-3-(2,4-dichlorophenyl)-1,5-dimethyl-N-pentylpyrazolo[4,3-b]pyridin-7-amine
CFAMM00319836 CHEMBL112626 Bioactive AGN-PC-074YVL
CFAMM00319829 CHEMBL323886 Bioactive AGN-PC-074YUN
CFAMM00319822 CHEMBL112045 Bioactive AGN-PC-074YTC
CFAMM00319835 CHEMBL325918 Bioactive AGN-PC-074YSV
CFAMM00319802 CHEMBL188907 Bioactive CHEMBL188907
CFAMM00319815 CHEMBL326156 Bioactive AGN-PC-074YQX
CFAMM00319828 CHEMBL112152 Bioactive N-(cyclopropylmethyl)-3-(2,4-dichlorophenyl)-1-ethyl-5-methyl-N-propylpyrazolo[4,3-b]pyridin-7-amine
CFAMM00319808 CHEMBL112290 Bioactive AGN-PC-074YX5
CFAMM00319834 CHEMBL116171 Bioactive AGN-PC-074YVD
CFAMM00319801 CHEMBL332721 Bioactive AGN-PC-074YQZ
CFAMM00319840 CHEMBL432976 Bioactive AGN-PC-074YQL
CFAMM00319800 CHEMBL112031 Bioactive AGN-PC-074YLV
CFAMM00319813 CHEMBL111838 Bioactive AGN-PC-074YSW
CFAMM00319826 CHEMBL117209 Bioactive 3-(2,4-dichlorophenyl)-N-(2-methoxyethyl)-1,5-dimethyl-N-propylpyrazolo[4,3-b]pyridin-7-amine
CFAMM00319806 CHEMBL332040 Bioactive AGN-PC-074YR1
CFAMM00319819 CHEMBL111665 Bioactive AGN-PC-074YT9
CFAMM00319832 CHEMBL115142 Bioactive N,N-dibutyl-3-(2,4-dichlorophenyl)-1,5-dimethylpyrazolo[4,3-b]pyridin-7-amine

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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