CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11323
Family Name Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor ionotropic, NMDA 2A ligand SureCN4814999 family
No. of Seeds 11 No. of Other Members 1
Family Centroid CFAMM00408405 Functional Category Bioactive
Superfamily Neuropeptide Y receptor type 1 and Glutamate receptor ionotropic, NMDA 1 Binder Superfamily
Class Class 1268

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Astemizole Family 7 240
Platelet-derived growth factor receptor Ligand CP-868596 Family 3 91
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
Tyrosine kinase Inhibitor PKI166 Family 17 198
D(2) dopamine receptor and D(3) dopamine receptor Ligand [2-(1... 17 100
Glutamate receptor ionotropic, NMDA 2B and Glutamate receptor ... 3 23
cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor 7-et... 7 57
Oestrogen receptor and Estrogen receptor beta Ligand 4-(3-phen... 5 14
Oestrogen receptor and Estrogen receptor beta Ligand 4-(2-phen... 2 9
Glycogen synthase kinase-3 beta and Mitogen-activated protein ... 8 8
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 50 17
Fatty-acid amide hydrolase 1 Inhibitor BMS-1 Family 5 22
Platelet-derived growth factor receptor alpha and Platelet-der... 3 18
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 13 15
Histamine H4 receptor ligand AGN-PC-07ZG9H family 4 4
Adenosine receptor A1 and Adenosine receptor A2b ligand 3-meth... 7 19
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 39 10
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 9 3
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 7 5
Neuropeptide Y receptor type 5 and Alpha-1A adrenergic recepto... 8 2
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 3
Survival motor neuron protein inhibitor CHEMBL1379159 family 1 10
Cellular tumor antigen p53 and Prelamin-A/C inhibitor CHEMBL14... 2 11
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
Transient receptor potential M8 protein ligand (3E)-3-[5-[2-(t... 4 2
Coagulation factor X and Cationic trypsin inhibitor AGN-PC-075... 26 7
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 3
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 1
Glutamate receptor ionotropic, NMDA 2B and Glutamate receptor ... 4 11
Plasma kallikrein and Coagulation factor VII inhibitor 2-[(3E)... 15 49
Serine/threonine-protein kinase Chk1 inhibitor SureCN6387344 f... 6 11
Platelet-derived growth factor receptor alpha and Vascular end... 3 1
Coagulation factor VII inhibitor [3-[(5E)-5-(5-carbamimidoyl-1... 3 2
Glutamate receptor ionotropic, NMDA 2B ligand 2-[[4-(4-chlorop... 4 1
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 2 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 2
Tyrosine-protein kinase Lck inhibitor 3-[[2-(benzimidazol-1-yl... 2 0
Transient receptor potential cation channel subfamily V member... 1 5
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 5
Interstitial collagenase and Matrilysin inhibitor (2R)-N'-hydr... 1 0
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 16 0
Cationic trypsin and Prothrombin inhibitor 2-ketobenzothiazole... 1 3
Rho-associated protein kinase 2 inhibitor SureCN1519463 family 5 1
5-hydroxytryptamine receptor 2B ligand SureCN1299002 family 2 8
Platelet-derived growth factor receptor beta and Fibroblast gr... 2 1
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-07CR... 4 0
Serine/threonine-protein kinase Chk2 inhibitor (6E)-4-fluoro-6... 3 6
Arachidonate 5-lipoxygenase-activating protein inhibitor 1-[(2... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00408403 CHEMBL223248 Bioactive 2-[(4-benzylpiperidin-1-yl)-hydroxymethylidene]-1,3-dihydrobenzimidazole-5,6-dione
CFAMM00408409 CHEMBL222665 Bioactive 2-[hydroxy-[4-[(3-methoxyphenyl)methyl]piperidin-1-yl]methylidene]-1,3-dihydrobenzimidazole-5,6-dione
CFAMM00408402 CHEMBL214758 Bioactive [4-[(4-fluorophenyl)methyl]piperidin-1-yl]-(6-hydroxy-1H-benzimidazol-2-yl)methanone
CFAMM00408408 CHEMBL220266 Bioactive (6-hydroxy-1H-benzimidazol-2-yl)-[4-[(3-methylphenyl)methyl]piperidin-1-yl]methanone
CFAMM00408401 CHEMBL222615 Bioactive 2-[hydroxy-[4-[(3-methylphenyl)methyl]piperidin-1-yl]methylidene]-1,3-dihydrobenzimidazole-5,6-dione
CFAMM00408407 CHEMBL220319 Bioactive [4-[(3-fluorophenyl)methyl]piperidin-1-yl]-(6-hydroxy-1H-benzimidazol-2-yl)methanone
CFAMM00408405 CHEMBL219634 Bioactive SureCN4814999
CFAMM00408412 CHEMBL220611 Bioactive 2-[[4-[(4-fluorophenyl)methyl]piperidin-1-yl]-hydroxymethylidene]-1,3-dihydrobenzimidazole-5,6-dione
CFAMM00408404 CHEMBL213172 Bioactive (6-hydroxy-1H-benzimidazol-2-yl)-[4-[(3-methoxyphenyl)methyl]piperidin-1-yl]methanone
CFAMM00408410 CHEMBL219737 Bioactive SureCN4812905

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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