CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11336
Family Name Substance-P receptor ligand (1R,2S,3S)-3-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-2-(4-fluorophenyl)-N-methylcyclopentan-1-amine family
No. of Seeds 8 No. of Other Members 0
Family Centroid CFAMM00408462 Functional Category Bioactive
Superfamily Substance-P receptor and Neuromedin-K receptor Binder Superfamily 2
Class Class 3228

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Clemastine Family 5 76
Alpha-1B adrenergic receptor ligand Morpholine derivative Phen... 4 152
Histamine H1 receptor ligand diphenylpiperidine analog Dipheny... 13 224
Nicotinic acetylcholine receptor Ligand Benztropine Mesylate F... 10 20
Muscarinic acetylcholine receptor Ligand Umeclidinium Family 7 50
Substance-P receptor Ligand L-733060 Family 19 71
Adenosine receptor A3 and Mu-type opioid receptor Ligand GBR-1... 80 110
Substance-P receptor Ligand SCH-388714 Family 26 8
Substance-P receptor ligand (1S,2R,5aS,7S,8aR,8bS)-7-amino-2-[... 12 2
Substance-P receptor ligand (2S)-3-[[3,5-bis(trifluoromethyl)p... 1 4
Substance-P receptor ligand 4-[[3,5-bis(trifluoromethyl)phenyl... 2 1
Substance-P receptor and Potassium voltage-gated channel subfa... 10 0
Substance-P receptor ligand 1-[[(1R,2R,3S)-3-[[3,5-bis(trifluo... 4 3
Substance-P receptor ligand 1-[(1R,2S,3S)-3-[[3,5-bis(trifluor... 7 2
Substance-P receptor ligand AGN-PC-03NGZP family 3 0
Substance-P receptor ligand 2-[[(1R,2S,3S)-3-[(1R)-1-[3,5-bis(... 5 0
Substance-P receptor ligand 1-[3-[[(1R)-1-[3,5-bis(trifluorome... 2 0
Substance-P receptor and Neuromedin-K receptor ligand 3-[[(1R)... 1 2
Substance-P receptor ligand 2-[[(1R,2S,3S)-3-[[3,5-bis(trifluo... 6 0
Substance-P receptor ligand (5R)-5-[[[(1R,2S,3S)-3-[(1R)-1-[3,... 6 0
Substance-P receptor and Sodium-dependent serotonin transporte... 6 1
Substance-P receptor ligand 1-[(3S,4R)-3-[(1R)-1-[3,5-bis(trif... 9 0
Substance-P receptor ligand (5S)-5-[(3S,4R)-3-[(1R)-1-[3,5-bis... 3 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 3 0
Substance-P receptor ligand SureCN8415737 family 3 4
Substance-P receptor ligand methyl 2-[(2S,3S)-2-[[3,5-bis(trif... 1 1
Sodium-dependent dopamine transporter and Sigma non-opioid int... 2 0
Substance-P receptor ligand SureCN8912140 family 2 12
Substance-P receptor ligand (3aR,4R,5S,7aS)-5-[(1R)-1-[3,5-bis... 4 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00408462 CHEMBL213515 Bioactive (1R,2S,3S)-3-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-2-(4-fluorophenyl)-N-methylcyclopentan-1-amine
CFAMM00408468 CHEMBL378331 Bioactive (1R,2S,3S)-3-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-2-(4-fluorophenyl)-N-(2-methoxyethyl)-N-methylcyclopentan-1-amine
CFAMM00408467 CHEMBL429715 Bioactive (1S,2R,3S)-3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-N-methyl-2-phenylcyclopentan-1-amine
CFAMM00408466 CHEMBL438789 Bioactive (1R,2S,3S)-3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-2-phenylcyclopentan-1-amine
CFAMM00408465 CHEMBL426145 Bioactive (1R,2S,3S)-3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-N-methyl-2-phenylcyclopentan-1-amine
CFAMM00408464 CHEMBL215889 Bioactive (1R,2S,3S)-3-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-N-ethyl-2-(4-fluorophenyl)cyclopentan-1-amine
CFAMM00408463 CHEMBL384796 Bioactive (1S,2R,3S)-3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-2-phenylcyclopentan-1-amine
CFAMM00408469 CHEMBL386151 Bioactive (1R,2S,3S)-3-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-2-(4-fluorophenyl)cyclopentan-1-amine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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