CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11358
Family Name Melanin-concentrating hormone receptor 1 ligand 3-[(1R,3R,6S)-3-[(5,6-dichloro-1H-benzimidazol-2-yl)-[3-(4-methylpiperazin-1-yl)propyl]amino]-6-bicyclo[4.1.0]heptanyl]benzonitrile family
No. of Seeds 6 No. of Other Members 6
Family Centroid CFAMM00408700 Functional Category Bioactive
Superfamily Melanin-concentrating hormone receptor 1 and Nociceptin receptor Binder Superfamily 2
Class Class 1016

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Mizolastine Family 14 603
HCV NS4B protein Inhibitor Clemizole Family 2 43
Tryptase Inhibitor Babim Family 12 90
Dipeptidyl peptidase 4 Inhibitor (5-phenyl-3h-benzo[d]imidazol... 5 13
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 4 3
RAF proto-oncogene serine/threonine-protein kinase and Serine/... 3 5
Melanin-concentrating hormone receptor 1 and Potassium voltage... 8 27
Melanin-concentrating hormone receptor 1 ligand AGN-PC-088XRP ... 2 10
Lysosomal Pro-X carboxypeptidase inhibitor 2-amino-N-[(2S)-1-[... 11 16
Transient receptor potential M8 protein ligand 2-[(E)-2-(oxan-... 5 3
Lysosomal Pro-X carboxypeptidase inhibitor N-[(1S)-1-(5,6-dich... 3 21
Melanin-concentrating hormone receptor 1 ligand AGN-PC-00BSP9 ... 6 12
Melanin-concentrating hormone receptor 1 ligand 3-[(1R,3R,6S)-... 2 4
Melanin-concentrating hormone receptor 1 ligand 3-[(1S,4R,5S)-... 3 0
Urokinase plasminogen activator surface receptor ligand 3-(1H-... 4 0
Mitogen-activated protein kinase 14 inhibitor 5-[2-(2,6-dichlo... 1 0
Substance-K receptor ligand SureCN9035669 family 10 5
Serine/threonine-protein kinase Chk1 inhibitor CHIR-124 family 1 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Platelet-derived growth factor receptor beta and Fibroblast gr... 10 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00408691 CHEMBL386035 Bioactive 5,6-dichloro-N-[(1R,3R,6S)-6-[3-[(dimethylamino)methyl]phenyl]-3-bicyclo[4.1.0]heptanyl]-N-[3-(4-methylpiperazin-1-yl)propyl]-1H-benzimidazol-2-amine
CFAMM00408697 CHEMBL385539 Bioactive 3-[(1R,3R,6S)-3-[(5-chloro-6-fluoro-1H-benzimidazol-2-yl)-[3-(4-methylpiperazin-1-yl)propyl]amino]-6-bicyclo[4.1.0]heptanyl]benzonitrile
CFAMM00408690 CHEMBL216681 Bioactive 3-[(1R,3R,6S)-3-[(5,6-dichloro-1H-benzimidazol-2-yl)-[(1-methylsulfonylpiperidin-4-yl)methyl]amino]-6-bicyclo[4.1.0]heptanyl]benzonitrile
CFAMM00408694 CHEMBL214470 Bioactive 3-[(1R,3R,6S)-3-[(5,6-dichloro-1H-benzimidazol-2-yl)-(piperidin-1-ylmethyl)amino]-6-bicyclo[4.1.0]heptanyl]benzonitrile
CFAMM00408700 CHEMBL215030 Bioactive 3-[(1R,3R,6S)-3-[(5,6-dichloro-1H-benzimidazol-2-yl)-[3-(4-methylpiperazin-1-yl)propyl]amino]-6-bicyclo[4.1.0]heptanyl]benzonitrile
CFAMM00408698 CHEMBL216368 Bioactive 3-[(1R,3R,6S)-3-[(5-chloro-6-fluoro-1H-benzimidazol-2-yl)-[(1-methylsulfonylpiperidin-4-yl)methyl]amino]-6-bicyclo[4.1.0]heptanyl]benzonitrile

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26858 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543