CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11366
Family Name Histamine H1 receptor and Alpha-1B adrenergic receptor ligand 5-[(4-chlorophenyl)methyl]-7-[[(2R)-1-methylpyrrolidin-2-yl]methyl]pyrido[2,3-d]pyridazin-8-one family
No. of Seeds 8 No. of Other Members 1
Family Centroid CFAMM00189035 Functional Category Bioactive
Superfamily Poly [ADP-ribose] polymerase 1 and Prothrombin Binder Superfamily
Class Class 1555

Cousin Family NamesSeedsMembers
Histamine H1 receptor ligand tricyclic antidepressant Loratadi... 5 163
Glycogen phosphorylase, muscle form Inhibitor PSN357 Family 3 253
D(4) dopamine receptor Ligand SPI-376 Family 7 84
Substance-P receptor Ligand TAK-637 Family 18 63
ABC294640 family 5 75
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 93
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Sodium channel protein type 10 subunit alpha Ligand N-benzyl-5... 11 46
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 5 22
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
RAC-alpha serine/threonine-protein kinase and Cyclin-dependent... 3 7
Vasopressin V2 receptor and Vasopressin V1a receptor ligand [2... 2 5
Histamine H3 receptor and Cytochrome P450 3A4 ligand AGN-PC-08... 15 5
Vasopressin V1b receptor ligand 2-[3-(3-chlorophenyl)-1-oxo-7-... 2 12
B1 bradykinin receptor ligand ELN-441958 family 1 0
Neuronal acetylcholine receptor subunit alpha-7 and Acetylchol... 2 3
Translocator protein inhibitor (2E)-N-(4-chlorophenyl)-N-methy... 2 13
Acetylcholinesterase inhibitor CHEMBL1651131 family 6 9
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor 2-... 18 2
Substance-P receptor and Neuromedin-K receptor ligand SureCN88... 4 14
Metabotropic glutamate receptor 5 ligand [2-[6-(3-chlorophenyl... 1 1
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 5 4
Beta-secretase 1 and Potassium voltage-gated channel subfamily... 2 11
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 6 8
Dual specificity protein kinase CLK4 and Mitogen-activated pro... 1 1
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 1
Nociceptin receptor and Mu-type opioid receptor ligand (1R,5R)... 4 17
NADPH oxidase 4 inhibitor 4-[[benzyl(methyl)amino]methyl]-2-(2... 1 4
Metabotropic glutamate receptor 5 ligand [2-[6-(3-chlorophenyl... 1 2
NADPH oxidase 4 and NADPH oxidase 1 inhibitor 2-(2-chloropheny... 2 5
Kinesin-like protein KIF11 inhibitor SureCN5863107 family 4 2


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

42686 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543