CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11385
Family Name Potassium voltage-gated channel subfamily H member 2 and Melanin-concentrating hormone receptor 1 ligand SureCN6331642 family
No. of Seeds 5 No. of Other Members 4
Family Centroid CFAMM00177260 Functional Category Bioactive
Superfamily Melanin-concentrating hormone receptor 1 and Melanin-concentrating hormone receptor 2 Binder Superfamily
Class Class 216

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Flecainide ... 2 162
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
Zucapsacin family 7 177
C-C chemokine receptor type 5 Ligand GW873140 Family 6 78
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 2 23
Cytochrome P450 2D6 and Delta-type opioid receptor Ligand 4-(s... 17 381
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
C-C chemokine receptor type 5 Ligand E-913 Family 6 44
5-hydroxytryptamine receptor 1A Ligand Robalzotan Family 9 41
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Histamine H3 receptor Ligand A-317920 Family 9 240
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 3 89
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Leukotriene B4 receptor 1 Ligand SC-51146 Family 6 315
Histamine H3 receptor Ligand A-349821 Family 49 228
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Acetylcholinesterase and Cholinesterase Inhibitor 3-[7-(benzyl... 22 303
Interstitial collagenase Inhibitor N-hydroxycarbamoylmethyl-4-... 5 24
Mitogen-activated protein kinase 14 Inhibitor N-(4-(trifluorom... 8 39
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Leukotriene A-4 hydrolase Inhibitor N5-[4-(2-oxo-3-phenylpropo... 1 61
Fatty-acid amide hydrolase 1 Inhibitor 3'-carbamoylbiphenyl-3-... 8 50
Macrophage migration inhibitory factor Inhibitor Benzofuran-2-... 5 67
Urotensin-2 receptor Ligand SB-436811 Family 6 71
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
D(2) dopamine receptor Ligand Epidepride Family 31 66
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 5 17
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 24 73
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 3 2
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 20 9
Renin inhibitor N-[(2S,4S,5S,7S)-7-[2-(1-acetylpiperidin-4-yl)... 2 1
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1
Prelamin-A/C and Beta-lactamase inhibitor CHEMBL1424193 family 1 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 4 4
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 3 10
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 2
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[3-... 4 2
DNA-dependent protein kinase catalytic subunit and Phosphatidy... 1 6
Prostaglandin E2 receptor EP4 subtype ligand SureCN5653729 family 3 2
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 3
Orexin receptor type 1 and Orexin receptor type 2 ligand [(2S)... 3 1
Mu-type opioid receptor ligand AGN-PC-075GAC family 16 8
MAP kinase-activated protein kinase 2 inhibitor 5-(4-cyanophen... 3 8
Nociceptin receptor and Kappa-type opioid receptor ligand AGN-... 1 3
Potassium voltage-gated channel subfamily H member 2 and Melan... 4 22
Melanin-concentrating hormone receptor 1 and Potassium voltage... 12 53
Histamine H3 receptor ligand SureCN5218144 family 4 6
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 3 191
Melanin-concentrating hormone receptor 1 and Potassium voltage... 1 0
Disintegrin and metalloproteinase domain-containing protein 17... 4 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 11
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 15
C-C chemokine receptor type 1 ligand SureCN8184421 family 11 10
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 7 1
Pol polyprotein inhibitor AC1LALH8 family 2 1
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 5
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 1 0
C-C chemokine receptor type 5 ligand (4-chlorophenyl) N-[1-[(4... 2 2
Muscarinic acetylcholine receptor M3 ligand N-[[3-[3-[(3-methy... 5 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
Mineralocorticoid receptor and Glucocorticoid receptor ligand ... 2 0
Cyclin-dependent kinase 5 and Cyclin-dependent kinase 5 activa... 2 110
NP (s)-1-(2-((2-methyl-4-oxo-3-phenoxy-4h-chromen-7-yl)oxy)ace... 3 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00408875 CHEMBL248297 Bioactive AGN-PC-00DEBH
CFAMM00408880 CHEMBL245844 Bioactive N-[1-[[4-[3-(2,4-dioxo-1,3-thiazolidin-3-yl)propoxy]-3-fluorophenyl]methyl]piperidin-4-yl]-7-fluoro-4-oxochromene-2-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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