CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11389
Family Name Sodium-dependent serotonin transporter and 5-hydroxytryptamine receptor 1A ligand SureCN5472190 family
No. of Seeds 6 No. of Other Members 159
Family Centroid CFAMM00256467 Functional Category Bioactive with Natural Product
Superfamily 5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin transporter Ligand Vilazodone Superfamily
Class Class 656

Cousin Family NamesSeedsMembers
Melatonin receptor type 1A Ligand Melatonin Family 20 988
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Vascular endothelial growth factor receptor 2 Ligand E 7080 Fa... 7 17
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
Vascular endothelial growth factor receptor 2 Ligand PF-003372... 1 4
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
Aromatase Inhibitor 2-phenyl-3-pyridin-4-ylmethylene-chroman-4... 3 30
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 2-benzyl-6-... 9 80
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Serine/threonine-protein kinase Chk1 Inhibitor A-432411 Family 4 70
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(furan-3-... 3 44
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 14 214
Mu-type opioid receptor Ligand 6-(4-(2-(benzylamino)ethyl)phen... 3 27
MO15-related protein kinase Pfmrk Inhibitor WR-289010 Family 2 506
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Oxytocin receptor and Vasopressin V1a receptor Ligand L-372662... 31 23
Renin Inhibitor CP-305202 Family 9 30
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 14
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 11
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... 1 18
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 20 28
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 11 391
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Vascular endothelial growth factor receptor 2 and Aurora kinas... 3 3
Vascular endothelial growth factor receptor 2 ligand 7-(6-acet... 2 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 8 12
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 2 21
Acetylcholinesterase and Butyrylcholinesterase inhibitor [3-[[... 3 68
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(2,3-... 2 0
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 3
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
Inosine-5'-monophosphate dehydrogenase 2 inhibitor 7-methoxy-2... 7 1
Glycylpeptide N-tetradecanoyltransferase 2 and Glycylpeptide N... 8 10
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 15
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 11 11
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 7 1
Histone deacetylase 3 and Histone deacetylase 9 inhibitor (3S,... 1 16
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 2
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 2
Peroxisome proliferator-activated receptor delta and Peroxisom... 3 17
Serine/threonine-protein kinase pim-2 and cGMP-dependent prote... 8 1
Vascular endothelial growth factor receptor 2 and Vascular end... 2 52
Peroxisome proliferator-activated receptor alpha and Peroxisom... 1 4
Cholinesterase and Acetylcholinesterase inhibitor 5-hydroxy-7-... 5 19
Platelet-derived growth factor receptor beta and Macrophage co... 1 4
Substance-P receptor ligand (3R)-4-[3,5-bis(trifluoromethyl)be... 2 3
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(1-... 3 2
Melanin-concentrating hormone receptor 1 ligand 3-[6-[3-(dimet... 1 13
Serine/threonine-protein kinase pim-1 inhibitor (2Z)-6-methoxy... 1 5
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 1 0
C-C chemokine receptor type 3 and Histamine H1 receptor ligand... 2 2
Beta-2 adrenergic receptor ligand SureCN4598646 family 7 7
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 2 ... 4 4
Acetylcholinesterase and Cholinesterase inhibitor 5-methoxy-7-... 1 18
Vasopressin V2 receptor and Vasopressin V1a receptor ligand 2-... 1 26
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 1 0
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 0
Histone deacetylase 3 and Histone deacetylase 9 inhibitor AGN-... 4 20
Substance-P receptor ligand SureCN2139814 family 7 7
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 6 8
Vasopressin V2 receptor and Vasopressin V1a receptor ligand Su... 2 2
Interstitial collagenase and Matrilysin inhibitor (3S,6R,7S)-N... 2 4
KiSS-1 receptor ligand [2-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S... 1 1
Substance-P receptor ligand AGN-PC-00FIT5 family 3 11
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 0
Ras guanyl-releasing protein 3 and Protein kinase C alpha type... 2 6
Glycogen synthase kinase-3 beta inhibitor bip-135 family 3 1
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 2 ... 6 1
5-hydroxytryptamine receptor 4 ligand 4-amino-5-chloro-N-[1-[8... 2 2
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 0
C-C chemokine receptor type 8 and Potassium voltage-gated chan... 5 1
Protein kinase C theta type and Protein kinase C delta type in... 13 0
Sodium-dependent serotonin transporter inhibitor SureCN5477150... 4 1
Mitogen-activated protein kinase 14 inhibitor SureCN4508019 fa... 1 0
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 3
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Aromatase inhibitor isoflavone deriv. 5m family 1 0
Leucyl-cystinyl aminopeptidase inhibitor SureCN988709 family 1 14
Histamine H1 receptor and Alpha-1B adrenergic receptor ligand ... 1 4
Aromatase inhibitor (4-chlorophenyl)-(6-methoxy-1-benzofuran-2... 1 4
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand [(6aR... 1 0
ATP-binding cassette sub-family G member 2 inhibitor 5-[(4-bro... 1 1
ATP-dependent DNA helicase Q1 and Ras-related protein Rab-9A i... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00409058 CHEMBL590245 Bioactive SureCN5474649
CFAMM00408888 CHEMBL2147764 Bioactive (2Z)-6-ethoxy-2-(1H-indol-3-ylmethylidene)-7-(piperazin-1-ylmethyl)-1-benzofuran-3-one
CFAMM00408887 CHEMBL2147763 Bioactive (2Z)-2-(1H-indol-3-ylmethylidene)-6-methoxy-7-(piperazin-1-ylmethyl)-1-benzofuran-3-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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