CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1139
Family Name Gonadotropin-releasing hormone receptor ligand 1-[(2,6-difluorophenyl)methyl]-5-(3-methoxyphenyl)-6-methyl-3-[(2R)-2-[methyl(pyridin-2-ylmethyl)amino]propyl]pyrimidine-2,4-dione family
No. of Seeds 6 No. of Other Members 31
Family Centroid CFAMM00319897 Functional Category Bioactive
Superfamily P2X purinoceptor 7 Inhibitor A-740003 Superfamily
Class Class 2472

Cousin Family NamesSeedsMembers
Melatonin receptor type 1A Ligand Melatonin Family 20 988
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
5-hydroxytryptamine receptor 1A Ligand Sun N4057 Family 2 86
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
Mu-type opioid receptor Ligand 6-(4-(2-(benzylamino)ethyl)phen... 3 27
Bifunctional epoxide hydrolase 2 Inhibitor N-benzyl-6-(3,3,3-t... 21 62
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 5
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Cytochrome P450 11B2, mitochondrial and Cytochrome P450 11B1, ... 9 7
Histamine H3 receptor ligand 3-[4-[3-[(2R)-2-methylpyrrolidin-... 1 5
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 4 11
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
Substance-P receptor ligand (3R)-4-[3,5-bis(trifluoromethyl)be... 2 3
Oxytocin receptor ligand (2R)-2-[(2R,5R)-5-(2,3-dihydro-1H-ind... 3 1
Gonadotropin-releasing hormone receptor ligand 2-tert-butyl-8-... 6 23
Acyl-CoA desaturase inhibitor SureCN1182719 family 1 0
Sodium-dependent serotonin transporter and Neuropeptide Y rece... 1 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 3
Orexin receptor type 1 and Orexin receptor type 2 ligand SureC... 1 3
TGF-beta receptor type-1 ligand SureCN373606 family 1 0
Peptidyl-prolyl cis-trans isomerase FKBP1A inhibitor Tetracycl... 3 1


External ID

Functional Category

Molecule Name

CFAMM00319929 CHEMBL321376 Bioactive 1-[(2,6-difluorophenyl)methyl]-5-(3-methoxyphenyl)-6-methyl-3-[(2R)-2-[methyl(2-pyridin-2-ylethyl)amino]propyl]pyrimidine-2,4-dione
CFAMM00319909 CHEMBL417645 Bioactive 1-[(2,6-difluorophenyl)methyl]-5-(2-fluoro-3-methoxyphenyl)-6-methyl-3-[2-[methyl(2-pyridin-2-ylethyl)amino]ethyl]pyrimidine-2,4-dione
CFAMM00319895 CHEMBL111820 Bioactive 1-[(2,6-difluorophenyl)methyl]-5-(3-methoxyphenyl)-6-methyl-3-[(2S)-2-[methyl(2-pyridin-2-ylethyl)amino]propyl]pyrimidine-2,4-dione
CFAMM00319914 CHEMBL23969 Bioactive SureCN13995198
CFAMM00319927 CHEMBL426780 Bioactive 1-[(2,6-difluorophenyl)methyl]-5-(2-fluoro-3-methoxyphenyl)-6-methyl-3-[(2S)-2-[methyl(pyridin-2-ylmethyl)amino]propyl]pyrimidine-2,4-dione
CFAMM00319897 CHEMBL112466 Bioactive 1-[(2,6-difluorophenyl)methyl]-5-(3-methoxyphenyl)-6-methyl-3-[(2R)-2-[methyl(pyridin-2-ylmethyl)amino]propyl]pyrimidine-2,4-dione

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Professor in Department of Pharmacy
National University of Singapore, Singapore

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