CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11400
Family Name D(3) dopamine receptor and D(2) dopamine receptor ligand [4-[2-[(2-amino-4,5,6,7-tetrahydro-1,3-benzothiazol-6-yl)-propylamino]ethyl]piperazin-1-yl]-(1H-indol-5-yl)methanone family
No. of Seeds 6 No. of Other Members 5
Family Centroid CFAMM00409121 Functional Category Bioactive with Natural Product
Superfamily D(2) dopamine receptor and D(3) dopamine receptor Binder Superfamily 8
Class Class 1642

Cousin Family NamesSeedsMembers
Abelson tyrosine-protein kinase 2 inhibitor thiazole derivativ... 19 50
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Macrophage metalloelastase Inhibitor PF-00356231 Family 5 79
Cathepsin B and Cathepsin K Inhibitor L-006235-1 Family 19 75
Poly [ADP-ribose] polymerase 1 Inhibitor N-(4-phenylthiazol-2-... 6 150
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-264... 6 32
Receptor tyrosine-protein kinase erbB-2 ligand AGN-PC-07ZDR2 f... 7 33
Neuropeptide Y receptor type 5 ligand N-[[(1S,5R)-3-(1-phenyle... 5 1
Coagulation factor X and Prothrombin inhibitor SureCN763988 fa... 31 86
Thyroid hormone receptor beta and Ferritin light chain ligand ... 3 10
Coagulation factor X and Prothrombin inhibitor (2S)-2-(benzyls... 4 4
Platelet-activating factor receptor ligand Foropafant family 2 0
Prothrombin inhibitor (3R,6S,8aS)-N-[5-(diaminomethylideneamin... 2 3
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 7 21
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 9 16
Mitogen-activated protein kinase 14 inhibitor N-[4-[2-ETHYL-4-... 4 5
Metabotropic glutamate receptor 1 and Metabotropic glutamate r... 8 4
Protein kinase C zeta type and Inhibitor of nuclear factor kap... 1 6
Orexin receptor type 2 and Orexin receptor type 1 ligand (2-me... 3 1
Orexin receptor type 1 and Orexin receptor type 2 ligand N-[[(... 9 5
Serine/threonine-protein kinase Chk1 inhibitor 2-(1H-indol-5-y... 2 2
Cathepsin K and Cathepsin L1 inhibitor (2R)-N-(cyanomethyl)-4-... 2 1
D(3) dopamine receptor and D(2) dopamine receptor ligand (E)-N... 7 11
D(3) dopamine receptor and D(2) dopamine receptor ligand [4-[2... 5 5
D(3) dopamine receptor ligand N-[4-[2-[[(6S)-2-amino-4,5,6,7-t... 4 1
D(3) dopamine receptor and D(2) dopamine receptor ligand 6-N-[... 3 0
Metabotropic glutamate receptor 5 ligand 5-methyl-N-(4-methyl-... 1 2
Eukaryotic translation initiation factor 2-alpha kinase 3 and ... 5 0
Histone deacetylase 1 inhibitor 5-[5-[[(2-chlorophenyl)methyla... 4 1
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 8 1
Cyclin-dependent kinase 5 and Cyclin-dependent kinase 5 activa... 4 4
Metabotropic glutamate receptor 1 ligand SureCN8238697 family 2 0
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 4 0
Glucocorticoid receptor ligand 3-(1H-indol-5-yl)-2,2-dimethyl-... 2 7
MAP kinase-activated protein kinase 2 inhibitor 2-[(4,4-dimeth... 11 11
Platelet-activating factor receptor ligand (1-ethylindol-3-yl)... 17 13
Gamma-aminobutyric acid receptor subunit alpha-2 and Gamma-ami... 6 4
Epidermal growth factor receptor and Vascular endothelial grow... 14 19
Tyrosine-protein kinase Lck inhibitor AGN-PC-074MSE family 18 2
Tyrosine-protein kinase Lck inhibitor AGN-PC-074MPV family 4 0
Tyrosine-protein kinase Lck inhibitor AGN-PC-03HL8Q family 4 0
Receptor-type tyrosine-protein kinase FLT3 ligand SureCN74238 ... 6 0
Poly [ADP-ribose] polymerase 1 inhibitor CHEMBL246396 family 22 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00409119 CHEMBL2148215 Bioactive N-[4-[2-[[(6S)-2-amino-4,5,6,7-tetrahydro-1,3-benzothiazol-6-yl]-propylamino]ethyl]cyclohexyl]isoquinoline-5-carboxamide
CFAMM00409118 CHEMBL2148214 Bioactive N-[4-[2-[[(6S)-2-amino-4,5,6,7-tetrahydro-1,3-benzothiazol-6-yl]-propylamino]ethyl]cyclohexyl]quinoline-5-carboxamide
CFAMM00409121 CHEMBL2152754 Bioactive [4-[2-[(2-amino-4,5,6,7-tetrahydro-1,3-benzothiazol-6-yl)-propylamino]ethyl]piperazin-1-yl]-(1H-indol-5-yl)methanone
CFAMM00409120 CHEMBL2152751 Bioactive [4-[2-[(2-amino-4,5,6,7-tetrahydro-1,3-benzothiazol-6-yl)-propylamino]ethyl]piperazin-1-yl]-(1H-indol-3-yl)methanone

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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