CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11404
Family Name Melanocortin receptor 4 and Melanocortin receptor 5 ligand (2R)-2-amino-N-[(1S)-1-[5-chloro-2-[4-[(2R)-3-(4-chloro-2-methoxyphenyl)-2-methylpropanoyl]piperazin-1-yl]phenyl]-2-methylpropyl]propanamide family
No. of Seeds 8 No. of Other Members 9
Family Centroid CFAMM00405017 Functional Category Bioactive
Superfamily Melanocortin receptor 4 and Sodium channel protein type 9 subunit alpha Binder Superfamily
Class Class 2065

Cousin Family NamesSeedsMembers
D(2) dopamine receptor ligand phenylpiperazine derivative Arip... 3 53
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Voltage-dependent L-type calcium channel Ligand Sq32,910 Family 1 25
D(4) dopamine receptor and D(2) dopamine receptor ligand 2-[4-... 2 6
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 3 9
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 7 9
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 6 16
Cathepsin L1 and Cathepsin S inhibitor arylaminoethyl amide, 5... 4 5
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial ... 3 3
Melanocortin receptor 4 ligand 3-amino-N-[(2R)-3-(2,4-dichloro... 1 9
Receptor-type tyrosine-protein kinase FLT3 ligand (3Z)-5-chlor... 1 4
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 6 11
Melanocortin receptor 4 ligand [4-[2-[(1S)-1-amino-3-methylbut... 1 0
Sodium channel protein type 9 subunit alpha ligand SureCN12900... 9 8


External ID

Functional Category

Molecule Name

CFAMM00409180 CHEMBL425261 Bioactive (2R)-1-[4-[2-[(1S)-1-amino-3-methylbutyl]-4-(trifluoromethyl)phenyl]piperazin-1-yl]-3-(4-chloro-2-methoxyphenyl)-2-methylpropan-1-one
CFAMM00409179 CHEMBL214886 Bioactive (2R)-1-[4-[2-[(1S)-1-amino-3-methylbutyl]-4-methylphenyl]piperazin-1-yl]-3-(4-chloro-2-methoxyphenyl)-2-methylpropan-1-one
CFAMM00409172 CHEMBL521715 Bioactive N-[(1S)-1-[2-[4-[(2R)-3-(4-chloro-2-methoxyphenyl)-2-methylpropanoyl]piperazin-1-yl]-3-fluorophenyl]-2-methylpropyl]azetidine-3-carboxamide
CFAMM00409178 CHEMBL468636 Bioactive N-[(1S)-1-[5-chloro-2-[4-[(2R)-3-(4-chloro-2-methoxyphenyl)-2-methylpropanoyl]piperazin-1-yl]phenyl]-2-methylpropyl]azetidine-3-carboxamide
CFAMM00409176 CHEMBL215066 Bioactive 1-[4-[2-[(1S)-1-amino-3-methylbutyl]-4-chlorophenyl]piperazin-1-yl]-3-(4-chloro-2-methoxyphenyl)-2-methylpropan-1-one

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

Last update by



42740 visits since 2014 .........


Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

All rights reserved.

Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links


Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543