CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11410
Family Name Alpha-2C adrenergic receptor and Alpha-2A adrenergic receptor ligand SureCN6822398 family
No. of Seeds 5 No. of Other Members 8
Family Centroid CFAMM00409233 Functional Category Bioactive
Superfamily Alpha-2C adrenergic receptor and Alpha-2A adrenergic receptor Binder Superfamily 2
Class Class 3108

Cousin Family NamesSeedsMembers
Glutamate dehydrogenase inhibitor quinoline derivative Chloroq... 7 189
Acetylcholinesterase Inhibitor Tacrine Family 12 515
Histamine H1 receptor Ligand Triprolidine Family 19 316
Food vacuoles Inhibitor Mefloquine Family 2 25
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
D(1B) dopamine receptor Ligand LE-300 Family 65 452
Amg 423 family 7 47
5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
Acetylcholinesterase Inhibitor Velnacrine Family 2 29
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 2
Protein kinase C theta type Inhibitor 4-(3h-indol-4-ylamino)-5... 2 2
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 19 108
Potassium voltage-gated channel subfamily A member 5 Ligand 2-... 5 69
DNA topoisomerase 1 Inhibitor 3-(4-phenyl-2,4'-bipyridin-6-yl)... 4 13
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapol Family 3 41
D(1B) dopamine receptor and D(2) dopamine receptor Ligand Flut... 1 6
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 38 35
Metabotropic glutamate receptor 5 Ligand (3-(2-methylquinolin-... 3 6
Metabotropic glutamate receptor 5 Ligand 3-m-tolyl-1,5-naphthy... 6 10
Metabotropic glutamate receptor 5 Ligand 2-phenylethynyl-5,6,7... 1 4
Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22
Protein kinase C alpha type Inhibitor Dequalinium Analogue Family 1 10
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 10 7
Androgen receptor ligand (6R,7S)-6-ethyl-7-methyl-4-(trifluoro... 22 29
Glucocorticoid receptor ligand SureCN5650626 family 17 25
Hepatocyte growth factor receptor ligand AGN-PC-08XYH3 family 1 0
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-09Q7W... 7 3
CGMP-dependent protein kinase inhibitor AGN-PC-075XII family 25 7
C-C chemokine receptor type 3 ligand 1-[(1R,2S)-2-[[3-[(4-fluo... 3 2
CGMP-dependent protein kinase inhibitor AGN-PC-075XJ0 family 9 1
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (2R)-... 1 0
Alpha-2C adrenergic receptor and Alpha-2B adrenergic receptor ... 1 0
5-hydroxytryptamine receptor 2A ligand (3R,4R)-3-(2-phenyl-1H-... 1 18
Platelet-activating factor receptor ligand SureCN9852997 family 1 1
Nociceptin receptor and Potassium voltage-gated channel subfam... 3 9
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 1,1,1... 12 3
Beta-3 adrenergic receptor ligand N-[4-[2-[[(2R)-2-hydroxy-2-p... 4 10
Sodium-dependent noradrenaline transporter and Sodium-dependen... 5 7
DNA topoisomerase 2-alpha and DNA topoisomerase 2-beta inhibit... 2 7


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00409242 CHEMBL217254 Bioactive [4-[4-[(3R)-3,4-dimethylpiperazin-1-yl]anilino]-3-methylquinolin-2-yl]methanol
CFAMM00409233 CHEMBL214996 Bioactive SureCN6822398
CFAMM00409239 CHEMBL217542 Bioactive [4-[4-[(3R)-3,4-dimethylpiperazin-1-yl]anilino]quinolin-3-yl]methanol
CFAMM00409238 CHEMBL268217 Bioactive SureCN6822429
CFAMM00409244 CHEMBL218675 Bioactive AGN-PC-00SUHI

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26388 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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