CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11413
Family Name Melanin-concentrating hormone receptor 1 and Melanin-concentrating hormone receptor 1 ligand SureCN5873754 family
No. of Seeds 9 No. of Other Members 2
Family Centroid CFAMM00244295 Functional Category Bioactive
Superfamily Melanin-concentrating hormone receptor 1 and Beta-secretase 1 Binder Superfamily
Class Class 877

Cousin Family NamesSeedsMembers
Mitogen-activated protein kinase 12 Inhibitor VX-702 Family 3 49
JAK Inhibitor Momelotinib Family 33 83
XL-888 family 16 85
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
Epidermal growth factor receptor and Receptor tyrosine-protein... 11 138
Lethal factor Inhibitor N,n'-bis(4-amino-2-methylquinolin-6-yl... 2 11
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 32
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor 1,3-... 7 2
Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... 2 5
Histamine H3 receptor Ligand 2-(4-isopropyl-piperazin-1-yl)-qu... 17 29
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
D(2) dopamine receptor and D(3) dopamine receptor Ligand A-706... 4 20
Poly [ADP-ribose] polymerase 1 Inhibitor 2-ethylquinoline-8-ca... 3 4
Cyclin-dependent kinase 2 and Mitogen-activated protein kinase... 7 30
Metabotropic glutamate receptor 5 Ligand 3-chloro-n-(6-chlorop... 2 5
Metabotropic glutamate receptor 5 Ligand 3-cyano-n-(6-methylpy... 4 3
Adenosine receptor A3 Ligand 1-(2-(diethylamino)quinazolin-4-y... 2 9
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Adenosine receptor A1 Ligand N-(4,6-diphenylpyrimidin-2-yl)ben... 4 8
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2,6... 22 18
Adenosine receptor A3 Ligand 2-aminoquinazoline-4-carboxyanili... 4 3
Histamine H4 receptor Ligand A-943931 Family 14 11
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 19 108
Urotensin-2 receptor Ligand Palosuran Family 4 4
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 1 3
Serine/threonine-protein kinase D1 inhibitor SureCN1424142 family 13 8
Melanin-concentrating hormone receptor 1 and Potassium voltage... 8 27
Melanin-concentrating hormone receptor 1 ligand AGN-PC-088XRP ... 2 10
Cathepsin K and Potassium voltage-gated channel subfamily H me... 4 7
5-hydroxytryptamine receptor 1A ligand AGN-PC-03ZB72 family 10 8
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 19
Mitogen-activated protein kinase 1 and Cytochrome P450 3A4 inh... 1 0
Adenosine receptor A2a ligand AGN-PC-077RWY family 4 5
Glucosylceramidase and Alpha-galactosidase A inhibitor AC1NNEG... 4 5
5-hydroxytryptamine receptor 1A ligand 2-[4-(quinolin-2-ylmeth... 2 91
Prelamin-A/C and Cellular tumor antigen p53 inhibitor CHEMBL16... 1 7
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 1
Dipeptidyl peptidase 4 inhibitor AGN-PC-09QKOM family 5 8
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 3 3
Toll-like receptor 7 ligand 6-amino-2-(butylamino)-9-[[4-(dime... 5 4
Melanin-concentrating hormone receptor 1 ligand SureCN3334191 ... 4 7
Corticotropin-releasing factor receptor 1 ligand Pyridopyrazin... 3 5
Dihydrofolate reductase inhibitor 1-[3-(2,4-diaminoquinazolin-... 2 4
Beta-secretase 1 inhibitor 3-[2-amino-6-(2-methylphenyl)quinol... 5 2
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 18 5
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 9 6
C-C chemokine receptor type 3 ligand 1-[(1R,2S)-2-[[3-[(4-fluo... 3 2
5-hydroxytryptamine receptor 3A ligand 3-methyl-N-[7-[[3-methy... 2 0
Substance-P receptor ligand 2-[3,5-bis(trifluoromethyl)phenyl]... 3 1
Translocator protein inhibitor N-butan-2-yl-4-(2-chlorophenyl)... 14 12
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-(4-quinolin-2-ylpi... 1 0
Substance-P receptor ligand Netupitant family 5 2
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 9 0
Microsomal triglyceride transfer protein large subunit inhibit... 13 0
Melanin-concentrating hormone receptor 1 ligand SureCN4261878 ... 4 7
Succinate receptor 1 ligand N-[[4-(3-methylphenyl)phenyl]methy... 2 14
Melanin-concentrating hormone receptor 1 ligand SureCN6198980 ... 13 0
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 2 0
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-[6-(3-methy... 2 5
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor 6-... 1 0
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 2
Disintegrin and metalloproteinase domain-containing protein 17... 2 1
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor (3R)-... 4 12
Histamine H4 receptor and Histamine H3 receptor ligand 7-cyclo... 2 0
Dipeptidyl peptidase 4 and Cytochrome P450 3A4 inhibitor 6-[(3... 7 7
C-X-C chemokine receptor type 3 ligand 1-[3-[[(1R,5S)-3-[[7-(t... 3 1
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 7 2
Mast/stem cell growth factor receptor Kit and Tyrosine-protein... 4 1
P2X purinoceptor 7 inhibitor 2-(1-adamantyl)-N-[2-(3-hydroxypr... 2 2
Dihydrofolate reductase inhibitor N-(2,4-diamino-5-methylquina... 2 0
P2Y purinoceptor 14 inhibitor AGN-PC-0A9S8H family 3 2
Acetyl-CoA carboxylase 2 and Acetyl-Coenzyme A carboxylase 2 i... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00409288 CHEMBL406704 Bioactive Aminoquinoline compound, 18
CFAMM00409286 CHEMBL260290 Bioactive AGN-PC-00R5WL
CFAMM00409284 CHEMBL258515 Bioactive Aminoquinoline compound, 20

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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