CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1142
Family Name Endothelin-1 receptor and Endothelin B receptor ligand SureCN795650 family
No. of Seeds 17 No. of Other Members 3
Family Centroid CFAMM00007204 Functional Category Bioactive
Superfamily Endothelin-1 receptor and Endothelin B receptor Binder Superfamily 3
Class Class 28

Cousin Family NamesSeedsMembers
Endothelin B receptor and Endothelin-1 receptor ligand pyrimid... 22 180
Tezosentan family 4 5
Macitentan family 18 1
Endothelin-1 receptor ligand AGN-PC-075B4O family 7 0
Endothelin-1 receptor ligand SureCN8801173 family 3 0
Endothelin-1 receptor ligand AGN-PC-00GZJQ family 12 0
Endothelin-1 receptor ligand SureCN8657460 family 1 0
Endothelin-1 receptor ligand AGN-PC-075B4U family 3 0
Endothelin B receptor and Endothelin-1 receptor ligand N-[5-(2... 2 1
Endothelin-1 receptor ligand AGN-PC-00FQOK family 4 0
Endothelin-1 receptor and Endothelin B receptor ligand 6-[2-(5... 3 1
Endothelin-1 receptor and Endothelin B receptor ligand 6-[2-(5... 7 0
Endothelin-1 receptor and Endothelin B receptor ligand N-(benz... 4 0
Endothelin-1 receptor and Endothelin B receptor ligand SureCN8... 1 0
Endothelin B receptor ligand RO468443 family 1 0


External ID

Functional Category

Molecule Name

CFAMM00319947 CHEMBL1627022 Bioactive sodium;[6-[2-(5-bromopyrimidin-2-yl)oxyethoxy]-5-(4-methylphenyl)pyrimidin-4-yl]-[4-(1-hydroxy-2-methylpropan-2-yl)phenyl]sulfonylazanide
CFAMM00319940 CHEMBL168904 Bioactive AGN-PC-02IJD9
CFAMM00319953 CHEMBL112134 Bioactive SureCN7482740
CFAMM00319946 CHEMBL111934 Bioactive N-[6-[2-(5-bromopyrimidin-2-yl)oxyethoxy]-5-(4-methylphenyl)pyrimidin-4-yl]-4-methoxybenzenesulfonamide
CFAMM00319939 CHEMBL324184 Bioactive AGN-PC-00IWWQ
CFAMM00319945 CHEMBL116220 Bioactive N-[6-[2-(5-bromopyrimidin-2-yl)oxyethoxy]-5-(4-methylphenyl)pyrimidin-4-yl]-4-iodobenzenesulfonamide
CFAMM00319938 CHEMBL324204 Bioactive AGN-PC-074YY4
CFAMM00319951 CHEMBL115017 Bioactive N-[6-[2-(5-bromopyrimidin-2-yl)oxyethoxy]-5-(4-methylphenyl)pyrimidin-4-yl]-4-(trifluoromethyl)benzenesulfonamide
CFAMM00319944 CHEMBL115372 Bioactive SureCN8659093
CFAMM00319943 CHEMBL112162 Bioactive N-[6-[2-(5-bromopyrimidin-2-yl)oxyethoxy]-5-(4-methylphenyl)pyrimidin-4-yl]-3,4-dimethoxybenzenesulfonamide
CFAMM00319949 CHEMBL177924 Bioactive AGN-PC-075B4T
CFAMM00319942 CHEMBL115147 Bioactive SureCN7206507
CFAMM00319948 CHEMBL424358 Bioactive N-[6-[2-(5-bromopyrimidin-2-yl)oxyethoxy]-5-(4-methylphenyl)-2-propan-2-ylpyrimidin-4-yl]-4-tert-butylbenzenesulfonamide

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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