CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11420
Family Name Beta-secretase 1 and Cathepsin D inhibitor N-[(2S,3R)-1-(3,5-difluorophenyl)-4-[[(4S)-6-(2,2-dimethylpropyl)-2,2-dimethyl-3,4-dihydrochromen-4-yl]amino]-3-hydroxybutan-2-yl]acetamide family
No. of Seeds 10 No. of Other Members 15
Family Centroid CFAMM00409332 Functional Category Bioactive
Superfamily Cathepsin D and Beta-secretase 1 Binder Superfamily 9
Class Class 4595

Cousin Family NamesSeedsMembers
HIV-1 protease Inhibitor Lopinavir Family 4 25
Beta-1 adrenergic receptor Ligand Nebivolol Family 5 22
Serine/threonine-protein kinase PLK1 Inhibitor On 019190.na Fa... 16 138
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
C-C chemokine receptor type 5 Ligand GW873140 Family 6 78
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
G protein-activated inward rectifier potassium channel 4 Ligan... 2 31
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Plasmepsin-1 and Plasmepsin-2 Inhibitor PS-777621 Family 11 13
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 25 50
Plasmepsin-2 Inhibitor PS-662477 Family 7 55
Histamine H3 receptor Ligand A-349821 Family 49 228
Pol polyprotein inhibitor tert-butyl N-[(2S,3S,5R)-5-benzyl-3-... 2 3
Pol polyprotein inhibitor 180968-31-4 family 8 13
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 55 36
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 6 1
Pol polyprotein inhibitor CHEMBL305466 family 4 7
Angiotensin-converting enzyme and Angiotensin-converting enzym... 3 13
Kappa-type opioid receptor and Cytochrome P450 2D6 ligand Sure... 4 0
Kappa-type opioid receptor and Cytochrome P450 2D6 ligand Sure... 4 3
Beta-secretase 1 and Cathepsin B inhibitor N-[(2S)-1-[[(2S,3R)... 2 1
Sodium-dependent serotonin transporter and Histamine H3 recept... 7 0
Beta-secretase 1 and Cathepsin D inhibitor N-[(2S,3R)-4-[[(4S)... 4 0
Beta-secretase 1 and Cathepsin E inhibitor 1-N-[(1R,2S)-3-(3,5... 3 8
Pol polyprotein inhibitor (3S)-N-tert-butyl-2-[(2R)-2-[(3S,6S,... 3 1
Beta-secretase 1 inhibitor 1-N-[(2S,3R)-1-(3,5-difluorophenyl)... 8 7
Renin inhibitor (2S,4S,5S,7S)-5-amino-4-hydroxy-7-[[4-methoxy-... 2 0
ATP-binding cassette sub-family C member 9 inhibitor SureCN482... 2 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00409337 CHEMBL2151150 Bioactive N-[(2S,3R)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydrochromene-2,1'-cyclobutane]-4-yl]amino]-3-hydroxy-1-phenylbutan-2-yl]acetamide
CFAMM00409330 CHEMBL2408756 Bioactive N-[(2S,3R)-1-(3,5-difluorophenyl)-4-[[(4S)-6-(2,2-difluoropropyl)-2,2-dimethyl-3,4-dihydrochromen-4-yl]amino]-3-hydroxybutan-2-yl]acetamide
CFAMM00409323 CHEMBL2158252 Bioactive N-[(2S,3R)-4-[[(4S)-6-(2,2-dimethylpropyl)-2,2-dimethyl-3,4-dihydrochromen-4-yl]amino]-3-hydroxy-1-phenylbutan-2-yl]acetamide
CFAMM00409329 CHEMBL2408755 Bioactive N-[(2S,3R)-1-(3,5-difluorophenyl)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydrochromene-2,1'-cyclopropane]-4-yl]amino]-3-hydroxybutan-2-yl]acetamide
CFAMM00409335 CHEMBL2408753 Bioactive N-[(2S,3R)-1-(3,5-difluorophenyl)-4-[[(2R,4S)-6-(2,2-dimethylpropyl)-2-(methoxymethyl)-2-methyl-3,4-dihydrochromen-4-yl]amino]-3-hydroxybutan-2-yl]acetamide
CFAMM00409334 CHEMBL2408752 Bioactive N-[(2S,3R)-1-(3,5-difluorophenyl)-4-[[(2R,4S)-6-(2,2-dimethylpropyl)-2-methyl-2-propyl-3,4-dihydrochromen-4-yl]amino]-3-hydroxybutan-2-yl]acetamide
CFAMM00409333 CHEMBL2408751 Bioactive N-[(2S,3R)-1-(3,5-difluorophenyl)-4-[[(2S,4S)-6-(2,2-dimethylpropyl)-2-methyl-2-propyl-3,4-dihydrochromen-4-yl]amino]-3-hydroxybutan-2-yl]acetamide
CFAMM00409332 CHEMBL2408750 Bioactive N-[(2S,3R)-1-(3,5-difluorophenyl)-4-[[(4S)-6-(2,2-dimethylpropyl)-2,2-dimethyl-3,4-dihydrochromen-4-yl]amino]-3-hydroxybutan-2-yl]acetamide
CFAMM00409331 CHEMBL2408757 Bioactive N-[(2S,3R)-4-[[(4S)-6-(2-cyano-2-methylpropyl)-2,2-dimethyl-3,4-dihydrochromen-4-yl]amino]-1-(3,5-difluorophenyl)-3-hydroxybutan-2-yl]acetamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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