CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11437
Family Name Acetylcholinesterase and Butyrylcholinesterase inhibitor (E)-3-(4-hydroxy-3-methoxyphenyl)-N-[8-(1,2,3,4-tetrahydroacridin-9-ylamino)octyl]prop-2-enamide family
No. of Seeds 4 No. of Other Members 5
Family Centroid CFAMM00377504 Functional Category Bioactive
Superfamily Acetylcholinesterase and Butyrylcholinesterase Binder Superfamily 2
Class Class 24

Cousin Family NamesSeedsMembers
DNA Binder Primaquine Family 3 245
Melatonin receptor type 1A Ligand Melatonin Family 20 988
Sodium channel protein type 5 subunit alpha Ligand Dibucaine F... 2 136
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Histamine N-methyltransferase inhibitor aminoquinoline Amodiaq... 8 23
Phospholipase A2 Inhibitor Quinacrine Family 13 95
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Multidrug resistance protein Inhibitor Tariquidar Family 3 60
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
Platelet-derived growth factor receptor alpha and Platelet-der... 2 17
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Adenosine receptor A1 and Adenosine receptor A3 Ligand 4-metho... 1 16
Melanin-concentrating hormone receptor 1 Ligand Gnf-pf-2322 Fa... 3 95
Serine/threonine-protein kinase Chk1 Inhibitor A-432411 Family 4 70
E3 ubiquitin-protein ligase Mdm2 Inhibitor NSC-66811 Family 4 27
Neuromedin-K receptor Ligand 3-methoxy-n',2-diphenylquinoline-... 14 33
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(4-methoxyphenyl)qu... 2 11
DNA topoisomerase 1 Inhibitor 3-(4-phenyl-2,4'-bipyridin-6-yl)... 4 13
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 38 35
Glucocorticoid receptor ligand 4-fluoro-2-[5,5,5-trifluoro-4-h... 3 9
Melanin-concentrating hormone receptor 1 and Cytochrome P450 3... 8 2
Hypoxia-inducible factor 1-alpha and Lethal factor inhibitor C... 1 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(1,3-... 2 9
Poly [ADP-ribose] polymerase 1 inhibitor SureCN5002485 family 2 11
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 7 4
Methionine--tRNA ligase inhibitor SureCN7818124 family 1 9
Androgen receptor ligand (6R,7S)-6-ethyl-7-methyl-4-(trifluoro... 22 29
Butyrylcholinesterase and Acetylcholinesterase inhibitor AGN-P... 9 24
Adenosine receptor A1 and Adenosine receptor A3 ligand AGN-PC-... 6 8
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-09Q7W... 7 3
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Disintegrin and metalloproteinase domain-containing protein 17... 13 3
Disintegrin and metalloproteinase domain-containing protein 17... 16 2
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 5
Cholinesterase and Acetylcholinesterase inhibitor tacrine deri... 10 0
Cholinesterase and Acetylcholinesterase inhibitor 6-[2-methoxy... 12 6
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 6 4
Cholinesterase and Acetylcholinesterase inhibitor 6-[4-[2-fluo... 17 0
D(1A) dopamine receptor and D(2) dopamine receptor ligand (6aR... 3 6
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 2
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-077PI... 4 0
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-077PJ... 4 4
Inositol monophosphatase 1 and Prelamin-A/C inhibitor GNF-Pf-3... 1 5
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00409388 CHEMBL257126 Bioactive (E)-3-(4-hydroxy-3-methoxyphenyl)-N-[5-(1,2,3,4-tetrahydroacridin-9-ylamino)pentyl]prop-2-enamide
CFAMM00409387 CHEMBL255304 Bioactive (E)-3-(4-hydroxy-3-methoxyphenyl)-N-[4-(1,2,3,4-tetrahydroacridin-9-ylamino)butyl]prop-2-enamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27430 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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