CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1144
Family Name Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptamine receptor 2A ligand N-(1-benzylpiperidin-4-yl)-N-methyl-3-phenylprop-2-ynamide;(E)-but-2-enedioic acid family
No. of Seeds 2 No. of Other Members 7
Family Centroid CFAMM00319991 Functional Category Bioactive
Superfamily Menin and D(4) dopamine receptor Binder Superfamily
Class Class 3231

Cousin Family NamesSeedsMembers
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Voltage-dependent T-type calcium channel subunit alpha-1H liga... 10 397
Histamine H1 receptor ligand piperazine derivative Cyclizine F... 16 140
5-hydroxytryptamine receptor 3A Ligand Palonosetron Family 12 403
Alpha-1B adrenergic receptor Ligand Lisdexamfetamine Family 14 443
Amine oxidase [flavin-containing] A Inhibitor Moclobemide Family 5 255
Glutathione S-transferase Inhibitor Praziquantel Family 5 167
Noradrenergic re-uptake and Serotonin re-uptake Inhibitor Diet... 29 276
DNA Binder Procarbazine Family 8 358
Muscarinic acetylcholine receptor M3 Ligand Diphemanil Methyls... 22 45
Substance-P receptor Ligand Orvepitant Family 11 46
Substance-P receptor Ligand Vestipitant Family 14 137
K-604 family 4 71
Bavisant family 9 65
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Reverse transcriptase Inhibitor 3-benzylamino-5-ethyl-6-methyl... 2 24
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Renin Inhibitor N-methyl-n-(methylbenzyl)formamide Family 2 17
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-m... 8 37
Beta-secretase 1 Inhibitor N-(1-benzylpiperidin-4-yl)-4-sulfan... 7 62
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
Farnesyltransferase beta subunit, putative and Protein farnesy... 6 3
Histone deacetylase 1 Inhibitor 8-(3-benzoyl-ureido)-octanoic ... 7 13
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(6... 1 12
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Caspase-3 Inhibitor 2-phenethylisoquinoline-1,3,4-trione Family 6 0
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 41 24
D(2) dopamine receptor and D(3) dopamine receptor Ligand ST-19... 5 27
Cannabinoid receptor 2 Ligand N1-(4-bromophenyl)-n2,n2-dipenty... 4 21
Sodium-dependent dopamine transporter and Sodium-dependent nor... 28 71
Cannabinoid receptor 1 Ligand N-(3,3-diphenyl)propyl-2-phenyla... 4 18
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 20 55
Fatty-acid amide hydrolase 1 Inhibitor 1-biphenyl-4-ylmethylma... 2 2
Aminopeptidase N Inhibitor N1,2-dibenzyl-n3-hydroxymalonamide ... 5 23
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 9 66
Arachidonate 5-lipoxygenase Inhibitor N-hydroxy-n-methyl-benza... 3 9
Sodium channel protein type 1 subunit alpha and Sodium channel... 4 31
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 2 80
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 17 9
Melatonin receptor type 1A Ligand N-(2,3-dihydro-1h-phenalen-2... 8 13
Aldose reductase Inhibitor (4-methyl-2-oxo-2h-quinolin-1-yl)-a... 1 15
Aminopeptidase N Inhibitor 2-benzyl-n1-hydroxy-n3-(4-phenylbut... 5 3
Aminopeptidase N Inhibitor N1-(4-chlorobenzyl)-2-benzyl-n3-hyd... 9 86
Sodium-dependent dopamine transporter and Sodium-dependent ser... 8 2
5-hydroxytryptamine receptor 2A Ligand N-(1-(3-bromobenzyl)pip... 6 10
Prolyl endopeptidase Inhibitor SUAM-1221 Family 42 47
Voltage-dependent calcium channel gamma-1 subunit Ligand NP-11... 8 9
C-C chemokine receptor type 5 ligand AC1NUIO8 family 12 11
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 2
C-C chemokine receptor type 5 ligand AC1L9USC family 3 2
Kappa-type opioid receptor ligand 6-[2-oxo-2-[(2S)-2-(pyrrolid... 6 4
Kappa-type opioid receptor ligand 1-[(2S)-2-(pyrrolidin-1-ylme... 4 0
Histamine H3 receptor ligand 1-(4-pentan-3-ylpiperazin-1-yl)-2... 3 1
Shiga toxin 1 variant B subunit and Shiga toxin 1 variant A su... 1 3
Acetylcholinesterase inhibitor 5-benzoyl-2-[2-(1-benzylpiperid... 2 3
Pyruvate kinase PKM and Huntingtin inhibitor CHEMBL1455935 family 1 3
Sigma non-opioid intracellular receptor 1 ligand 2-(3-bromophe... 5 1
Dipeptidyl peptidase 2 and Dipeptidyl peptidase 4 inhibitor (2... 3 10
Kinesin-like protein KIF11 and Potassium voltage-gated channel... 4 1
Histamine H3 receptor and Potassium voltage-gated channel subf... 9 0
Histamine H3 receptor and Acetylcholinesterase ligand 1-[4-[[4... 1 2
Melanin-concentrating hormone receptor 1 and Cytochrome P450 2... 3 4
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 2 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 5 6
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 1
Nociceptin receptor and Kappa-type opioid receptor ligand Pipe... 1 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 3 1
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 6 7
Follicle-stimulating hormone receptor ligand N-[[3-[4-[[(2S,5S... 7 0
Kappa-type opioid receptor ligand SureCN5629426 family 3 2
Plasmepsin-2 inhibitor SureCN8292428 family 1 2
Histamine H3 receptor ligand 1-[4-[4-(pyrrolidin-1-ylmethyl)ph... 4 2
C-C chemokine receptor type 5 ligand AC1MHPA7 family 2 2
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 0
Lanosterol synthase and Squalene--hopene cyclase inhibitor AGN... 2 5
Pdk3 protein and [Pyruvate dehydrogenase (acetyl-transferring)... 3 0
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 1 0
Arachidonate 5-lipoxygenase inhibitor AGN-PC-075QQO family 1 1
Retinal dehydrogenase 1 and Muscleblind-like protein 1 inhibit... 1 0
Phenylpropenes Metabolite (E)-1-Cinnamoylpyrrolidine Family 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00319991 CHEMBL111964 Bioactive N-(1-benzylpiperidin-4-yl)-N-methyl-3-phenylprop-2-ynamide;(E)-but-2-enedioic acid
CFAMM00319988 CHEMBL325063 Bioactive (E)-N-(1-benzylpiperidin-4-yl)-N-methyl-3-phenylprop-2-enamide;(E)-but-2-enedioic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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