CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11442
Family Name Cholesteryl ester transfer protein inhibitor 1-[(1S)-1-(5-chloropyridin-2-yl)-1-[3-fluoro-5-(trifluoromethyl)phenyl]-2-phenylethyl]-3-(3,3-difluorocyclopentyl)urea family
No. of Seeds 1 No. of Other Members 4
Family Centroid CFAMM00409422 Functional Category Bioactive
Superfamily 5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine receptor 2C Ligand 6-chloro-n-(pyridin-3-yl)indoline-1-carboxamide Superfamily
Class Class 88

Cousin Family NamesSeedsMembers
D(2) dopamine receptor Ligand Sertindole Family 3 173
Transient receptor potential cation channel subfamily V member... 16 295
Amg 423 family 7 47
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
5-hydroxytryptamine receptor 2B Ligand Sb 206553 Family 14 21
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
Potassium voltage-gated channel subfamily H member 2 Ligand 5-... 5 14
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 9
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 1
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 11 20
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 8
Prostaglandin E synthase inhibitor AGN-PC-09QHBK family 3 1
Prostaglandin E synthase and Aldo-keto reductase family 1 memb... 3 12
Mitogen-activated protein kinase 14 inhibitor 4-(2-chloro-4-fl... 6 7
C-C chemokine receptor type 3 ligand 1-[(1R,2S)-2-[[3-[(4-fluo... 3 2
Macrophage colony-stimulating factor 1 receptor and Vascular e... 2 3
Melanin-concentrating hormone receptor 1 and 5-hydroxytryptami... 2 0
Neuropeptide Y receptor type 5 ligand SureCN4464548 family 17 2
Melanin-concentrating hormone receptor 1 and Potassium voltage... 1 0
Sterol O-acyltransferase 1 inhibitor SureCN7073167 family 4 2
Transient receptor potential cation channel subfamily V member... 2 0
Reverse transcriptase/RNaseH inhibitor (4s)-6-chloro-4-cyclopr... 5 3
Acyl-CoA:cholesterol acyltransferase inhibitor AGN-PC-00GCQW f... 2 1


External ID

Functional Category

Molecule Name

CFAMM00409422 CHEMBL2152158 Bioactive 1-[(1S)-1-(5-chloropyridin-2-yl)-1-[3-fluoro-5-(trifluoromethyl)phenyl]-2-phenylethyl]-3-(3,3-difluorocyclopentyl)urea

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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