CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1149
Family Name D(4) dopamine receptor and Alpha-1B adrenergic receptor ligand 1-(4-chlorophenyl)-4-[[(1S,2S)-2-phenylcyclopropyl]methyl]piperazine;hydrobromide family
No. of Seeds 7 No. of Other Members 27
Family Centroid CFAMM00286769 Functional Category Bioactive
Superfamily D(4) dopamine receptor and Alpha-1B adrenergic receptor Binder Superfamily
Class Class 3297

Cousin Family NamesSeedsMembers
Benzodiazepine receptor ligand benzodiazepine derivative Fludi... 11 78
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Voltage-dependent T-type calcium channel subunit alpha-1H liga... 10 397
Noradrenergic re-uptake inhibitor Dibenzazepine Imipramine Family 8 178
Gamma-aminobutyric acid receptor subunit alpha-1 ligand benzod... 1 2
Serotonin re-uptake inhibitor Dibenzazepine Clomipramine Family 2 23
Nuclear receptor subfamily 1 group I member 3 ligand piperazin... 3 82
D(2) dopamine receptor Ligand Nomifensine Family 6 100
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 23
Sigma non-opioid intracellular receptor 1 Ligand MS-377 Family 1 21
Serine/threonine-protein kinase mTOR Inhibitor CC-223 Family 12 135
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
5-hydroxytryptamine receptor 2A and Alpha-1A adrenergic recept... 1 19
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 67
5-hydroxytryptamine receptor 6 Ligand [2-(3h-indol-1-yl)-ethyl... 2 7
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 8 32
Dipeptidyl peptidase 4 Inhibitor 1-benzyl-4-(2,4-dichloropheny... 2 10
Histamine H3 receptor Ligand (r)-1-(4-nitrophenethyl)-2-methyl... 16 38
Phospholipase D1 Inhibitor Halopemide Family 17 111
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 5 47
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 3 34
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 5 18
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 45
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
D(4) dopamine receptor and Alpha-1B adrenergic receptor ligand... 1 2
D(4) dopamine receptor and D(2) dopamine receptor ligand 2-[4-... 1 0
D(4) dopamine receptor and Alpha-1B adrenergic receptor ligand... 2 6
Melanocortin receptor 4 ligand tert-butyl 4-[(3S)-4-[4-[2-[1-[... 2 6
5-hydroxytryptamine receptor 2A ligand AGN-PC-075LXD family 4 4
D(3) dopamine receptor and D(2) dopamine receptor ligand 3-[4-... 4 23
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 3 0
C-C chemokine receptor type 1 ligand SureCN3159355 family 7 9
Sigma non-opioid intracellular receptor 1 ligand 1-[4-[1-adama... 4 23
Sigma non-opioid intracellular receptor 1 ligand 1-[(3-nitroph... 4 2
P2X purinoceptor 7 inhibitor SureCN3726471 family 3 0
P2X purinoceptor 7 inhibitor AGN-PC-088GOO family 3 0
P2X purinoceptor 7 inhibitor SureCN3721807 family 3 0
P2X purinoceptor 7 inhibitor AGN-PC-088GBV family 1 0
Substance-P receptor ligand (2R,3R)-2-benzhydryl-N-(2-iodophen... 2 0
Kappa-type opioid receptor and Urotensin-2 receptor ligand 2-(... 5 1
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 14 0
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 1 0
Sigma non-opioid intracellular receptor 1 and 3-beta-hydroxyst... 1 1
D(4) dopamine receptor and 5-hydroxytryptamine receptor 2A lig... 1 4
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 0
Potassium voltage-gated channel subfamily H member 2 and D(3) ... 3 0
C-C chemokine receptor type 5 ligand AC1MHPA7 family 2 2
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand (3R,6... 5 3
P2X purinoceptor 7 inhibitor SureCN3720401 family 1 0
Nitric oxide synthase, brain and Nitric oxide synthase, induci... 1 2
Lysosomal Pro-X carboxypeptidase and Glutamate receptor ionotr... 1 0
Sigma non-opioid intracellular receptor 1 and Sodium-dependent... 2 1
Sodium-dependent noradrenaline transporter inhibitor SureCN329... 1 0
Cholinesterase inhibitor 10-[[(1R,9aR)-2,3,4,6,7,8,9,9a-octahy... 1 0
Trypanothione reductase inhibitor 3-(6-chloro-2-methyl-4-pheny... 9 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00320050 CHEMBL1204116 Bioactive 1-(2,4-dichlorophenyl)-4-[[(1S,2S)-2-phenylcyclopropyl]methyl]piperazine;hydrobromide
CFAMM00320036 CHEMBL302075 Bioactive 1-(2,4-dichlorophenyl)-4-[[(1S,2S)-2-phenylcyclopropyl]methyl]piperazine
CFAMM00320042 CHEMBL1202219 Bioactive 1-(2-chlorophenyl)-4-[[(1S,2S)-2-(4-fluorophenyl)cyclopropyl]methyl]piperazine;hydrobromide
CFAMM00320041 CHEMBL112125 Bioactive AC1MN9CK
CFAMM00320045 CHEMBL1202215 Bioactive 1-(2-chlorophenyl)-4-[[(1S,2S)-2-phenylcyclopropyl]methyl]piperazine;hydrobromide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

45073 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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