CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11491
Family Name Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor ionotropic, NMDA 2A ligand AGN-PC-0764TR family
No. of Seeds 4 No. of Other Members 1
Family Centroid CFAMM00409725 Functional Category Bioactive
Superfamily Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Inhibitor XL147 Superfamily
Class Class 857

Cousin Family NamesSeedsMembers
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand be... 4 301
5-hydroxytryptamine receptor Ligand Ramosetron Family 10 219
Amiloride-sensitive sodium channel subunit alpha Ligand Triamt... 8 98
Histamine H1 receptor Ligand Mizolastine Family 14 603
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
SB989 family 17 91
Vascular endothelial growth factor receptor 2 Ligand XL999 Family 11 87
Tryptase Inhibitor Babim Family 12 90
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2,6-di... 13 14
Vascular endothelial growth factor receptor 2 Ligand 6-(1h-ben... 2 5
Methionine aminopeptidase 2 Inhibitor 2-(pyridin-2-yl)-1h-benz... 6 19
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Telomerase reverse transcriptase Inhibitor HOE-33258 Family 10 33
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 2
Prothrombin and Cationic trypsin inhibitor (2S)-N-[(2S)-1-(1H-... 4 15
Prothrombin inhibitor SureCN5856722 family 3 16
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 4 3
Histamine H4 receptor ligand SureCN602132 family 1 8
Melanin-concentrating hormone receptor 1 ligand AGN-PC-088XRP ... 2 10
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 7 10
C-C chemokine receptor type 5 ligand SureCN1573831 family 4 3
D(4) dopamine receptor and D(2) dopamine receptor ligand 4-met... 13 8
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 4 2
Coagulation factor X and Trypsin-1 inhibitor 1-(3-carbamimidoy... 4 1
Transient receptor potential M8 protein ligand 2-[(E)-2-(oxan-... 5 3
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 9 10
Coagulation factor X and Cationic trypsin inhibitor AGN-PC-075... 5 13
Melanin-concentrating hormone receptor 1 ligand SureCN3334191 ... 4 7
C-C chemokine receptor type 5 ligand methyl N-cyano-4-[2-[(1R,... 8 8
Coagulation factor X and Coagulation factor IX inhibitor 5-ami... 9 4
Mitogen-activated protein kinase 14 inhibitor 6-[5-(2,4-difluo... 9 3
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
Serine/threonine-protein kinase mTOR inhibitor 5-(2-amino-3H-b... 3 1
Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[5... 4 11
Vascular endothelial growth factor receptor 2 ligand (3Z)-6-fl... 4 3
Platelet-derived growth factor receptor beta and Vascular endo... 5 12
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 2 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 9 0
Neuropeptide Y receptor type 5 ligand 2-(3-phenylpiperidin-1-y... 6 2
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Metabotropic glutamate receptor 2 ligand 8-(2,5-difluorophenyl... 6 2
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 2
Matrilysin and Stromelysin-1 inhibitor (2R)-N-[(1S)-1-(1H-benz... 3 0
Substance-K receptor ligand SureCN9035669 family 10 5
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 2 0
Serine/threonine-protein kinase Chk1 inhibitor CHIR-124 family 1 0
Gonadotropin-releasing hormone receptor ligand SureCN3275214 f... 5 0
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-077RDJ family 15 1
Gonadotropin-releasing hormone receptor ligand 4-[[4-[2-(4-ter... 3 3
Gonadotropin-releasing hormone receptor and 5-hydroxytryptamin... 2 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Tyrosine-protein kinase ITK/TSK and Insulin receptor ligand AG... 5 1
Melanin-concentrating hormone receptor 1 ligand SureCN3832854 ... 3 2
B1 bradykinin receptor ligand AGN-PC-077LWO family 2 0
Platelet-derived growth factor receptor beta and Fibroblast gr... 10 0
Melanin-concentrating hormone receptor 1 ligand SureCN3834858 ... 2 1
5-hydroxytryptamine receptor 2B ligand SureCN1299053 family 1 1
Platelet-derived growth factor receptor beta and Fibroblast gr... 2 1
Dipeptidyl peptidase 4 and Potassium voltage-gated channel sub... 1 0
Glutamate receptor 1 and Glutamate receptor 2 ligand 4-(1-azab... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00409727 CHEMBL363010 Bioactive SureCN4551013
CFAMM00409726 CHEMBL424752 Bioactive N-[2-(4-benzylpiperidine-1-carbonyl)-6-(methanesulfonamido)-3H-benzimidazol-5-yl]methanesulfonamide
CFAMM00409725 CHEMBL215372 Bioactive AGN-PC-0764TR
CFAMM00409724 CHEMBL363722 Bioactive SureCN4552037

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27510 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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