CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11500
Family Name Delta-type opioid receptor ligand N-[(7S)-5-(3-hydroxyphenyl)-4-methyl-2-(3-phenylpropyl)-2-azabicyclo[3.3.1]nonan-7-yl]-1-phenylcyclopentane-1-carboxamide family
No. of Seeds 9 No. of Other Members 3
Family Centroid CFAMM00409782 Functional Category Bioactive
Superfamily Mu-type opioid receptor Ligand Alvimopan Superfamily
Class Class 323

Cousin Family NamesSeedsMembers
Opioid receptor ligand opiate Levorphanol Family 18 537
Kappa-type opioid receptor Ligand Dezocine Family 36 46
Mu-type opioid receptor Ligand Alvimopan Family 32 325
Thymopentin family 20 133
Noradrenergic re-uptake and Opioid receptor Ligand Tapentadol ... 21 79
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
Neuropeptide Y receptor type 1 Ligand Bibp 3226 Family 43 80
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
C-C chemokine receptor type 5 Ligand E-913 Family 6 44
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 20 35
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Disintegrin and metalloproteinase domain-containing protein 17... 25 36
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Estradiol 17-beta-dehydrogenase 1 Inhibitor N-n-diethyl Estrad... 6 16
Histamine H3 receptor Ligand A-349821 Family 49 228
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Estradiol 17-beta-dehydrogenase 1 Inhibitor N-ethyl Estrone-16... 3 5
Estradiol 17-beta-dehydrogenase 1 Inhibitor N-isopropyl Estrad... 3 0
Angiopoietin-1 receptor and Cyclin-dependent kinase 1 Inhibito... 2 10
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 9 12
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 23 9
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 31 5
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 49 19
Mu-type opioid receptor Ligand H-tyr-d-ala-aic-asp-val-val-gly... 48 8
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 44 3
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 48 10
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 95 46
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 3 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 6 19
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 1 0
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 3 10
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 4 2
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 11 2
Kinesin-like protein KIF11 and Potassium voltage-gated channel... 2 1
Delta-type opioid receptor ligand N-[(1S,4R,5R,7S)-5-(3-hydrox... 2 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 6 2
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 15 4
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 2 4
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 1
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 15
C-C chemokine receptor type 1 ligand SureCN8184421 family 11 10
Oxysterols receptor LXR-beta and Oxysterols receptor LXR-alpha... 1 1
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 0
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 1 0
5-hydroxytryptamine receptor 1A ligand 8-[4-[[(2S)-5-fluoro-8-... 4 3
Neuropeptide Y receptor type 1 and Sodium-dependent serotonin ... 2 7
C-C chemokine receptor type 3 and Probable C-C chemokine recep... 5 2
Glutamate receptor ionotropic, NMDA 2B ligand AGN-PC-076B5T fa... 1 0
C-C chemokine receptor type 2 ligand (E)-N-[(1S,3R)-3-[[4-(4-m... 1 6


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00409787 CHEMBL387222 Bioactive N-[(1S,4R,5R,7S)-5-(3-hydroxyphenyl)-4-methyl-2-(2-phenoxyethyl)-2-azabicyclo[3.3.1]nonan-7-yl]-2-methyl-2-phenylpropanamide
CFAMM00409780 CHEMBL379389 Bioactive 1-(4-fluorophenyl)-N-[(1S,4R,5R,7S)-5-(3-hydroxyphenyl)-4-methyl-2-(3-phenylpropyl)-2-azabicyclo[3.3.1]nonan-7-yl]cyclopentane-1-carboxamide
CFAMM00409779 CHEMBL377540 Bioactive N-[(1S,4R,5R,7S)-5-(3-hydroxyphenyl)-4-methyl-2-(3-phenylpropyl)-2-azabicyclo[3.3.1]nonan-7-yl]-1-phenylcycloheptane-1-carboxamide
CFAMM00409784 CHEMBL94741 Bioactive AGN-PC-008BDT
CFAMM00409790 CHEMBL215693 Bioactive N-[(1S,4R,5R,7S)-5-(3-hydroxyphenyl)-4-methyl-2-(3-phenylpropyl)-2-azabicyclo[3.3.1]nonan-7-yl]-1-phenylcyclobutane-1-carboxamide
CFAMM00409783 CHEMBL329754 Bioactive N-[(7R)-5-(3-hydroxyphenyl)-4-methyl-2-(3-phenylpropyl)-2-azabicyclo[3.3.1]nonan-7-yl]-1-phenylcyclopentane-1-carboxamide
CFAMM00409782 CHEMBL329470 Bioactive N-[(7S)-5-(3-hydroxyphenyl)-4-methyl-2-(3-phenylpropyl)-2-azabicyclo[3.3.1]nonan-7-yl]-1-phenylcyclopentane-1-carboxamide
CFAMM00409788 CHEMBL377044 Bioactive N-[(1S,4R,5R,7S)-5-(3-hydroxyphenyl)-4-methyl-2-(3-phenylpropyl)-2-azabicyclo[3.3.1]nonan-7-yl]-1-(4-methoxyphenyl)cyclopentane-1-carboxamide
CFAMM00409781 CHEMBL377386 Bioactive N-[(1S,5R,7S)-5-(3-hydroxyphenyl)-4-methyl-2-(3-phenylpropyl)-2-azabicyclo[3.3.1]nonan-7-yl]-1-phenylcyclopentane-1-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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