CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11505
Family Name Neuropeptide Y receptor type 5 ligand 2-(3-phenylpiperidin-1-yl)-6-propylsulfonyl-1H-benzimidazole family
No. of Seeds 6 No. of Other Members 2
Family Centroid CFAMM00409809 Functional Category Bioactive
Superfamily Neuropeptide Y receptor type 5 and Cytochrome P450 1A2 Binder Superfamily
Class Class 2756

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Mizolastine Family 14 603
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
HCV NS4B protein Inhibitor Clemizole Family 2 43
SB989 family 17 91
Tryptase Inhibitor Babim Family 12 90
Interleukin-1 receptor type 1 and Mitogen-activated protein ki... 7 151
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 1 9
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-(4-e... 2 5
Dipeptidyl peptidase 4 Inhibitor (5-phenyl-3h-benzo[d]imidazol... 5 13
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Potassium voltage-gated channel subfamily H member 2 Ligand AZ... 21 42
Hepatocyte growth factor receptor Ligand 3-(phenylsulfonyl)-1h... 17 59
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 55
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 4
Sterol O-acyltransferase 1 inhibitor 1-(2,4-difluorophenyl)-3-... 8 90
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 6 60
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 4 3
Melanin-concentrating hormone receptor 1 ligand AGN-PC-088XRP ... 2 10
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 27
Nociceptin receptor and Kappa-type opioid receptor ligand 1-[1... 4 4
Pol polyprotein and Reverse transcriptase/RNaseH inhibitor AC1... 6 11
Growth hormone secretagogue receptor type 1 and Dihydrofolate ... 3 6
Transient receptor potential M8 protein ligand 2-[(E)-2-(oxan-... 5 3
Thymidylate synthase inhibitor AGN-PC-003VKA family 1 1
Thymidylate synthase inhibitor AGN-PC-003VK7 family 1 4
Melanin-concentrating hormone receptor 1 ligand SureCN3334191 ... 4 7
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 5
Cannabinoid receptor 2 ligand 2-tert-butyl-5-ethylsulfonyl-1-(... 28 32
Fatty-acid amide hydrolase 1 inhibitor 5-[5-(4-chlorophenyl)su... 2 4
Gonadotropin-releasing hormone receptor ligand AGN-PC-009WYJ f... 1 4
Mitogen-activated protein kinase 14 inhibitor 6-[5-(2,4-difluo... 9 3
Cyclin-dependent kinase 1 inhibitor 4-[[4-(3H-benzimidazol-5-y... 1 0
Cannabinoid receptor 2 ligand 2-tert-butyl-1-(oxan-4-ylmethyl)... 8 2
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 4-[[2... 3 0
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 10 6
Aurora kinase B and Vascular endothelial growth factor recepto... 1 2
Complement C1s subcomponent and Coagulation factor X inhibitor... 1 22
Neuropeptide Y receptor type 5 and Cytochrome P450 1A2 ligand ... 8 19
Neuropeptide Y receptor type 5 ligand 1-phenyl-5-[6-(2,2,2-tri... 4 1
C-C chemokine receptor type 2 ligand N-[(1S,2R,4R)-2-(benzenes... 7 9
Melanin-concentrating hormone receptor 1 ligand AGN-PC-00BSP9 ... 6 12
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 4 1
Neuropeptide Y receptor type 5 ligand 2-phenyl-4-(6-propylsulf... 12 5
C-C chemokine receptor type 3 ligand 5-fluoro-1-[1-[3-(4-fluor... 1 2
Mitogen-activated protein kinase 14 inhibitor 6-[2-(2,6-difluo... 3 0
Neuropeptide Y receptor type 5 ligand 2-(2,2-difluoro-2-phenyl... 2 2
Neuropeptide Y receptor type 5 ligand 6-ethylsulfonyl-2-(4-phe... 4 4
Neuropeptide Y receptor type 5 ligand (6-ethylsulfonyl-1H-benz... 1 1
Melanin-concentrating hormone receptor 1 and Potassium voltage... 4 4
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor AG... 3 1
Cannabinoid receptor 2 ligand 4-[[2-tert-butyl-1-(cyclohexylme... 2 0
Cannabinoid receptor 2 ligand 4-[2-tert-butyl-1-(oxan-4-ylmeth... 5 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 1 0
Cannabinoid receptor 2 ligand 5-chloro-6-[(4-chlorophenyl)meth... 1 0
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 2 3
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Nociceptin receptor and Mu-type opioid receptor ligand 2-(3-ch... 2 0
5-hydroxytryptamine receptor 2B ligand SureCN1299053 family 1 1
Sodium/hydrogen exchanger 1 inhibitor 2-[(E)-[2-(1H-benzimidaz... 3 14
Dipeptidyl peptidase 4 and Potassium voltage-gated channel sub... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00409806 CHEMBL2158014 Bioactive 2-(4-methyl-3-phenylpiperazin-1-yl)-6-propylsulfonyl-1H-benzimidazole
CFAMM00409812 CHEMBL559940 Bioactive (2R,3R)-7-methylsulfonyl-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-2-amine;2,2,2-trifluoroacetic acid
CFAMM00409805 CHEMBL560192 Bioactive (2R,3R)-7-ethylsulfonyl-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-2-amine;2,2,2-trifluoroacetic acid
CFAMM00409810 CHEMBL2159157 Bioactive 2-(3-phenylpiperazin-1-yl)-6-propylsulfonyl-1H-benzimidazole
CFAMM00409809 CHEMBL2159158 Bioactive 2-(3-phenylpiperidin-1-yl)-6-propylsulfonyl-1H-benzimidazole
CFAMM00409807 CHEMBL2159174 Bioactive 2-(3-phenylpyrrolidin-1-yl)-6-propylsulfonyl-1H-benzimidazole

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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