CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11515
Family Name Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 inhibitor methyl 4-methyl-2-[2-(2-oxochromen-4-yl)oxypropanoylamino]pentanoate family
No. of Seeds 3 No. of Other Members 191
Family Centroid CFAMM00409883 Functional Category Bioactive with Natural Product
Superfamily Caspase-1 and Disintegrin Binder Superfamily
Class Class 412

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Flecainide ... 2 162
Glycoprotein IIb/IIIa receptor Ligand Tirofiban Family 4 173
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
Integrin alpha-4 Inhibitor Firategrast Family 3 93
Acolbifene family 10 115
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Voltage-dependent N-type calcium channel subunit alpha-1B Liga... 2 2
Plasmepsin-1 and Plasmepsin-2 Inhibitor PS-777621 Family 11 13
Disintegrin and metalloproteinase domain-containing protein 17... 25 36
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Leukotriene B4 receptor 1 Ligand SC-51146 Family 6 315
Cannabinoid receptor 1 Ligand N-(3,5-dimethoxyphenethyl)oleami... 5 49
Amine oxidase [flavin-containing] A Inhibitor 7-acetonyloxy-3-... 1 5
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 9 12
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Carbonic anhydrase 9 and Carbonic anhydrase 12 Inhibitor Ethox... 12 80
Cytochrome P450 2D6 Inhibitor 4-methylaminomethyl-7-methoxycou... 3 80
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 3 2
Disintegrin and metalloproteinase domain-containing protein 17... 1 2
D(4) dopamine receptor and D(3) dopamine receptor ligand 3-ben... 5 334
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(4S)-3... 3 24
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2,6-... 16 23
Pol polyprotein inhibitor MDL 74538 family 11 1
Potassium voltage-gated channel subfamily H member 2 and Melan... 5 4
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 2 0
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 2 0
Renin inhibitor (3S,6R)-6-(cyclohexylmethyl)-7-hydroxy-7-[[(2S... 1 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2R)-3-[4-(2-me... 18 1
Cathepsin S and Cathepsin L1 inhibitor benzyl N-[(2S)-1-oxo-1-... 2 2
D(4) dopamine receptor and D(3) dopamine receptor ligand 3-ben... 3 2
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 1 0
Cathepsin K and Cathepsin L1 inhibitor dipeptidyl nitrile, 16c... 1 0
Acetylcholinesterase and Butyrylcholinesterase inhibitor [3-[[... 1 65
Caspase-1 inhibitor 3-[[(2S)-2-[[(2S)-3-methyl-2-(phenylmethox... 1 3
3-oxo-5-alpha-steroid 4-dehydrogenase 2 inhibitor SureCN807991... 1 1
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 2 3
Metabotropic glutamate receptor 1 ligand methyl (2R)-2-[[(1aR,... 2 0
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 5 3
Amine oxidase [flavin-containing] B inhibitor (2S)-1-[[7-[(3-f... 2 15
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00410030 CHEMBL2158357 Bioactive N-benzyl-2-(2-oxochromen-4-yl)oxypropanamide
CFAMM00409883 CHEMBL2158363 Bioactive methyl 4-methyl-2-[2-(2-oxochromen-4-yl)oxypropanoylamino]pentanoate
CFAMM00409885 CHEMBL2158361 Bioactive 4-(1-oxo-1-pyrrolidin-1-ylpropan-2-yl)oxychromen-2-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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