CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11536
Family Name Tyrosine-protein kinase JAK1 and Non-receptor tyrosine-protein kinase TYK2 ligand CHEMBL2159210 family
No. of Seeds 7 No. of Other Members 0
Family Centroid CFAMM00160707 Functional Category Bioactive
Superfamily C-Jun N-terminal kinase Inhibitor CC-930 Superfamily
Class Class 1333

Cousin Family NamesSeedsMembers
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
5-hydroxytryptamine receptor 1D Ligand Rizatriptan Family 7 460
Toll-like receptor 7 Ligand Imiquimod Family 3 237
Metabotropic glutamate receptor 5 Ligand ADX-48621 Family 15 444
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Transient receptor potential cation channel subfamily V member... 15 457
Transient receptor potential cation channel subfamily V member... 6 66
Cyclin-dependent kinase 2 Inhibitor Seliciclib Family 29 292
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
Cyclin-dependent kinase 4 Inhibitor PD-332991 Family 13 155
Tyrosine-protein kinase JAK2 Inhibitor INCB18424 Family 3 130
Adenosine receptor A3 Ligand CF101 Family 24 560
Translocator protein Inhibitor Emapunil Family 7 89
Adenosine receptor A2a Ligand MRE-0094 Family 10 108
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Adenosine receptor A1 Ligand SLV320 Family 6 79
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
GDC-0349 family 44 77
C-Jun N-terminal kinase Inhibitor CC-930 Family 2 9
JAK Inhibitor Momelotinib Family 33 83
Vascular endothelial growth factor receptor 2 Ligand XL999 Family 11 87
PF-4217903 family 14 65
Tryptase Inhibitor Babim Family 12 90
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Glucan synthesis regulatory protein Inhibitor Pyridobenzimidaz... 2 12
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Prostaglandin G/H synthase 2 Inhibitor RWJ-67657 Family 3 33
Poly [ADP-ribose] polymerase 1 Inhibitor EB-47 Family 17 41
Adenosine receptor A1 and Adenosine receptor A2a Ligand N6-met... 7 72
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2,6-di... 13 14
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Adenosine receptor A2a and Adenosine receptor A3 Ligand 5-buty... 3 18
Arachidonate 5-lipoxygenase Inhibitor 2,4,5-triarylimidazole A... 3 16
Methionine aminopeptidase 2 Inhibitor 2-(pyridin-2-yl)-1h-benz... 6 19
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Adenosine receptor A1 Ligand Phenyl-(9-phenyl-9h-purin-6-yl)-a... 7 12
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
Adenosine receptor A1 and Adenosine receptor A2a Ligand GW-328... 26 94
RAC-gamma serine/threonine-protein kinase and Rho-associated p... 16 46
Adenosine receptor A3 and Dual specificity mitogen-activated p... 5 27
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-[(4-... 15 9
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-(3''... 12 5
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-(3''... 2 2
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-(3''... 2 3
Adenosine receptor A2a and Adenosine receptor A3 Ligand 2-(3''... 8 10
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Potassium voltage-gated channel subfamily H member 2 Ligand AZ... 21 42
Serine/threonine-protein kinase mTOR Inhibitor 4-(2-(1h-indol-... 2 15
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Histamine H3 receptor Ligand 4-(2-(phenylamino)ethyl)-1h-imida... 5 16
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Inositol 1,4,5-trisphosphate receptor type 3 Ligand 5'-deoxy-5... 11 8
Adenosine kinase inhibitor GP683 family 12 7
Adenosine receptor A3 and Adenosine receptor A2a ligand 5-buty... 3 13
Adenosine kinase inhibitor abt-702 family 14 1
Prothrombin inhibitor SureCN5856722 family 3 16
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 2 3
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 7 3
Aurora kinase A inhibitor AGN-PC-07ZZEH family 2 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 3 12
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 7 1
Mitogen-activated protein kinase 8 and Mitogen-activated prote... 2 5
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 34 11
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 46 9
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 13 10
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase inh... 17 17
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 13
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase inh... 7 6
S-methyl-5'-thioadenosine phosphorylase inhibitor SureCN997478... 8 0
C-X-C chemokine receptor type 4 and Envelope glycoprotein gp16... 2 2
RAC-alpha serine/threonine-protein kinase and Proline-rich AKT... 2 4
Sorbitol dehydrogenase inhibitor SureCN6335187 family 2 6
Mitogen-activated protein kinase 14 inhibitor AGN-PC-03XQYG fa... 7 1
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 4 4
Prothrombin and Trypsin-1 inhibitor 2-[6-methyl-2-oxo-3-(2-pyr... 4 2
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 1 0
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 21 32
Insulin-like growth factor 1 receptor ligand AGN-PC-09QIDN family 1 3
Glycogen synthase kinase-3 beta and Dual specificity protein k... 4 5
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 5
Calcitonin gene-related peptide type 1 receptor ligand SureCN1... 6 0
Toll-like receptor 7 ligand 4-amino-1-[[6-[(2S)-2-(pyrrolidin-... 4 0
Adenosine deaminase inhibitor AGN-PC-00FYYU family 4 5
S-methyl-5'-thioadenosine phosphorylase inhibitor 1-[(4-amino-... 7 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 4 2
Serine/threonine-protein kinase mTOR inhibitor 5-(2-amino-3H-b... 3 1
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 1 0
Adenosine kinase inhibitor (2R,3R,4R)-2-[4-(2,3-dihydro-1,4-be... 5 2
Adenosine kinase inhibitor 2-[[7-[(2R,3R,4S,5R)-3,4-dihydroxy-... 15 0
Adenosine kinase inhibitor SureCN8320660 family 7 2
Protein kinase C theta type and Leucine-rich repeat serine/thr... 1 1
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 1 0
Transient receptor potential cation channel subfamily V member... 4 0
Aurora kinase A and Aurora kinase B inhibitor [4-[[7-cyclopent... 6 0
Dual specificity protein kinase TTK inhibitor 4-[[2-(2-methyl-... 1 0
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
Casein kinase II subunit alpha inhibitor N-[5-[[3-cyano-7-(cyc... 3 0
Somatostatin receptor type 3 and Potassium voltage-gated chann... 3 0
Somatostatin receptor type 3 ligand tert-butyl 4-[(3R)-3-(5-ph... 2 2
S-methyl-5'-thioadenosine phosphorylase inhibitor 2-[[(4-amino... 5 0
Activated CDC42 kinase 1 inhibitor N,N-dimethyl-4-[4-[[(2S)-ox... 4 2
Mitogen-activated protein kinase 14 inhibitor imidazole 81 family 2 1
Aurora kinase A and Cyclin-dependent kinase 4 inhibitor 7-cycl... 1 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152412 family 8 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152398 family 16 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 1
Smoothened homolog inhibitor N-[4-chloro-3-(5-phenyl-1H-imidaz... 4 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Somatostatin receptor type 3 and Potassium voltage-gated chann... 3 3
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206058 family 5 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206614 family 2 0
Receptor-type tyrosine-protein kinase FLT3 and Aurora kinase A... 2 0
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 0
Adenosine receptor A3 ligand (2R,3R,4S)-2-[2-chloro-6-[(3-fluo... 6 7
Adenosine receptor A1 and Adenosine receptor A3 ligand N-benzy... 4 2
Tyrosine-protein kinase JAK1 and Aurora kinase A inhibitor CHE... 2 0
Serine/threonine-protein kinase ATR and Serine/threonine-prote... 8 10
Protein kinase C theta type and Protein kinase C delta type in... 9 0
Serine/threonine-protein kinase mTOR inhibitor 2-[4-[4-[(3S)-3... 3 0
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 16 0
Mitogen-activated protein kinase 8 and Mitogen-activated prote... 2 1
Serine/threonine-protein kinase PLK2 and Serine/threonine-prot... 1 2
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
Tyrosine-protein kinase ITK/TSK and Aurora kinase B inhibitor ... 1 1
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 3
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 1
Cathepsin K inhibitor SureCN4141224 family 3 0
Cyclin-dependent kinase 1 and Proto-oncogene tyrosine-protein ... 5 13
Cathepsin K inhibitor SureCN4138062 family 7 0
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 16 7
Nociceptin receptor and Potassium voltage-gated channel subfam... 5 2
LIM domain kinase 2 inhibitor (2S)-N-cyano-N'-(3-cyanophenyl)-... 4 0
Vascular endothelial growth factor receptor 2 and Vascular end... 1 1
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 3 0
Gamma-aminobutyric acid receptor subunit pi and Gamma-aminobut... 4 0
G2/mitotic-specific cyclin-B2 and Cyclin-dependent kinase 1 in... 2 1
C-C chemokine receptor type 3 and Cytochrome P450 2D6 ligand 1... 1 0
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Proto-oncogene tyrosine-protein kinase Src and Tyrosine-protei... 3 0
Aurora kinase B and Aurora kinase A inhibitor 1-cyclohexyl-3-[... 4 0
Metabotropic glutamate receptor 1 ligand AGN-PC-00FV3S family 2 0
Cyclin-dependent kinase 2 inhibitor SureCN3549598 family 3 1
Serine/threonine-protein kinase B-raf inhibitor imidazole-base... 2 0
TGF-beta receptor type-1 and Mitogen-activated protein kinase ... 1 0
5-hydroxytryptamine receptor 3A ligand AGN-PC-077D8K family 3 1
Tyrosine-protein kinase Lck inhibitor (3S)-3-[(1S)-1-[[4-(benz... 14 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 26 0
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor (2S)-2-[[9-p... 4 5


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00410237 CHEMBL2206628 Bioactive CHEMBL2206628
CFAMM00410236 CHEMBL2386628 Bioactive CHEMBL2386628

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27398 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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