CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11552
Family Name Smoothened homolog inhibitor N-[4-chloro-3-(5-phenyl-1H-imidazol-2-yl)phenyl]-6-[(2R,6S)-2,6-dimethylmorpholin-4-yl]isoquinolin-1-amine family
No. of Seeds 4 No. of Other Members 1
Family Centroid CFAMM00410391 Functional Category Bioactive
Superfamily Smoothened homolog and Dipeptidyl peptidase 4 Binder Superfamily
Class Class 2257

Cousin Family NamesSeedsMembers
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
HCV NS4B protein Inhibitor Clemizole Family 2 43
GDC-0349 family 44 77
JAK Inhibitor Momelotinib Family 33 83
PF-4217903 family 14 65
Tryptase Inhibitor Babim Family 12 90
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Prostaglandin G/H synthase 2 Inhibitor RWJ-67657 Family 3 33
Histamine H3 receptor Ligand SCH79687 Family 11 29
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2,6-di... 13 14
Adenosine receptor A3 Ligand 2,6-bis(4-chlorophenyl)-9h-purine... 4 12
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Arachidonate 5-lipoxygenase Inhibitor 2,4,5-triarylimidazole A... 3 16
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
RAC-gamma serine/threonine-protein kinase and Rho-associated p... 16 46
Adenosine receptor A3 and Dual specificity mitogen-activated p... 5 27
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Dipeptidyl peptidase 4 Inhibitor (5-phenyl-3h-benzo[d]imidazol... 5 13
Aromatase and Cytochrome P450 26A1 Inhibitor Liarozole Family 4 1
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Glycogen synthase kinase-3 beta Inhibitor CHIR-98023 Family 5 6
Serine/threonine-protein kinase mTOR Inhibitor 4-(2-(1h-indol-... 2 15
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Amine oxidase [flavin-containing] A Inhibitor 3-benzyl-n-(2-mo... 2 3
Adenosine receptor A3 and Adenosine receptor A2a ligand 5-buty... 3 13
Aurora kinase A inhibitor AGN-PC-07ZZEH family 2 4
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 7 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 34 11
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 13 10
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 13
RAF proto-oncogene serine/threonine-protein kinase and Serine/... 3 5
Aurora kinase A and Aurora kinase B inhibitor 3uol family 6 5
Mitogen-activated protein kinase 14 inhibitor AGN-PC-03XQYG fa... 7 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 1 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 5 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 0
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 3
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 3
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
Serine/threonine-protein kinase mTOR inhibitor 5-(2-amino-3H-b... 3 1
Mast/stem cell growth factor receptor Kit and Receptor-type ty... 8 3
Transient receptor potential cation channel subfamily V member... 4 0
Dual specificity protein kinase TTK inhibitor 4-[[2-(2-methyl-... 1 0
Cannabinoid receptor 2 ligand 8-(2-chlorophenyl)-9-cyclopropyl... 4 5
Somatostatin receptor type 3 and Potassium voltage-gated chann... 3 0
Somatostatin receptor type 3 ligand tert-butyl 4-[(3R)-3-(5-ph... 2 2
Transient receptor potential cation channel subfamily V member... 4 0
Aurora kinase A and Cyclin-dependent kinase 4 inhibitor 7-cycl... 1 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152398 family 16 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 1
Tyrosine-protein kinase JAK1 and Non-receptor tyrosine-protein... 7 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-[1-... 5 3
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206614 family 2 0
Receptor-type tyrosine-protein kinase FLT3 and Aurora kinase A... 2 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 6 3
Serine/threonine-protein kinase ATR and Serine/threonine-prote... 8 10
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 5 2
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 16 0
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
Mitogen-activated protein kinase 10 inhibitor CYCLOPROPYL-{4-[... 2 1
RAF proto-oncogene serine/threonine-protein kinase and Serine/... 4 3
Mitogen-activated protein kinase 14 inhibitor 5-[2-(2,6-dichlo... 1 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Tyrosine-protein kinase Lck inhibitor AGN-PC-03IU3J family 2 0
Serine/threonine-protein kinase B-raf inhibitor 1-[2-[[4-[2-cy... 2 0
Gamma-aminobutyric acid receptor subunit pi and Gamma-aminobut... 4 0
Proto-oncogene tyrosine-protein kinase Src and Tyrosine-protei... 3 0
Metabotropic glutamate receptor 1 ligand AGN-PC-00FV3S family 2 0
Serine/threonine-protein kinase B-raf inhibitor imidazole-base... 2 0
TGF-beta receptor type-1 and Mitogen-activated protein kinase ... 1 0
Prostaglandin E synthase inhibitor AGN-PC-014WPB family 1 0
Tyrosine-protein kinase Lck inhibitor (3S)-3-[(1S)-1-[[4-(benz... 14 0
Insulin-like growth factor 1 receptor ligand SureCN2967184 family 2 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00410392 CHEMBL2160073 Bioactive N-[4-chloro-3-(5-phenyl-1H-imidazol-2-yl)phenyl]-6-(1,1-dioxo-1,4-thiazinan-4-yl)isoquinolin-1-amine
CFAMM00410391 CHEMBL2160072 Bioactive N-[4-chloro-3-(5-phenyl-1H-imidazol-2-yl)phenyl]-6-[(2R,6S)-2,6-dimethylmorpholin-4-yl]isoquinolin-1-amine
CFAMM00410394 CHEMBL2160074 Bioactive N-[4-chloro-3-(5-phenyl-1H-imidazol-2-yl)phenyl]-6-[(2R)-2-methylmorpholin-4-yl]isoquinolin-1-amine
CFAMM00410393 CHEMBL2160077 Bioactive N-[4-chloro-3-(5-phenyl-1H-imidazol-2-yl)phenyl]-6-morpholin-4-ylisoquinolin-1-amine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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