CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11553
Family Name Smoothened homolog inhibitor N-[4-methyl-3-(5-phenyl-1H-imidazol-2-yl)phenyl]-4-morpholin-4-ylbenzamide family
No. of Seeds 1 No. of Other Members 0
Family Centroid CFAMM00410396 Functional Category Bioactive
Superfamily Vasopressin V1a receptor and Vasopressin V2 receptor Ligand Conivaptan Superfamily
Class Class 86

Cousin Family NamesSeedsMembers
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand be... 4 301
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Reverse transcriptase Inhibitor Delavirdine Family 1 68
5-hydroxytryptamine receptor Ligand Ramosetron Family 10 219
Tubulin beta chain Inhibitor Mebendazole Family 12 84
Peptide deformylase, mitochondrial inhibitor folic acid analog... 59 98
Prothrombin Inhibitor Dabigatran Family 7 182
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 5 129
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
BIBT986 family 7 96
IPI-145 family 2 4
GDC-0349 family 44 77
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 37 10
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
PHA848125 family 13 138
CC-486 family 7 103
JAK Inhibitor Momelotinib Family 33 83
Eluxadoline family 4 85
Vascular endothelial growth factor receptor 2 Ligand XL999 Family 11 87
XL-888 family 16 85
Platelet activating factor, putative Inhibitor ABT-491 Family 22 62
Integrin alpha-V and Integrin beta-3 Inhibitor SB-223245 Family 27 36
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
Dipeptidyl peptidase 4 Inhibitor (5-phenyl-3h-benzo[d]imidazol... 5 13
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Adenosine receptor A1 and Adenosine receptor A2a Ligand OSIP-3... 4 31
Telomerase reverse transcriptase Inhibitor NSC-745794 Family 3 1
Serine/threonine-protein kinase mTOR Inhibitor 4-(2-(1h-indol-... 2 15
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Type-2 angiotensin II receptor Ligand L-158282 Family 24 58
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 13 15
Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7
Serine/threonine-protein kinase B-raf Inhibitor Pyrazolo[1,5-a... 7 77
Prothrombin and Cationic trypsin inhibitor (2S)-N-[(2S)-1-(1H-... 4 15
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 4
Prothrombin inhibitor SureCN5856722 family 3 16
Beta-3 adrenergic receptor and Beta-2 adrenergic receptor liga... 2 12
Acetylcholinesterase inhibitor SureCN251059 family 2 16
Adenosine receptor A2a and Adenosine receptor A1 ligand 2-amin... 10 48
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 12
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-07ZE3... 6 1
Aurora kinase B and Aurora kinase A inhibitor AGN-PC-07RDWA fa... 1 4
RAC-alpha serine/threonine-protein kinase inhibitor SureCN4728... 11 6
Macrophage colony-stimulating factor 1 receptor and Cytochrome... 13 3
Platelet-activating factor receptor ligand 5-methyl-2-[4-(2-me... 1 2
Smoothened homolog inhibitor SureCN1091571 family 2 2
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
Cathepsin K and Potassium voltage-gated channel subfamily H me... 4 7
Tyrosine-protein kinase ABL1 inhibitor 5-[(5-{[4-{[4-(2-Hydrox... 4 1
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor AGN-PC... 2 4
Adenosine receptor A2a ligand SureCN14156209 family 3 2
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-09M45... 8 1
Cell division cycle 7-related protein kinase inhibitor pyrrolo... 4 10
Poly [ADP-ribose] polymerase 1 inhibitor ethyl 4-(4-carbamoyl-... 2 15
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 3 6
Peroxisome proliferator-activated receptor gamma ligand 1-[(4-... 7 29
Glutamate receptor 1 and Glutamate receptor 2 ligand SureCN831... 2 29
Inositol monophosphatase 1 and 15-hydroxyprostaglandin dehydro... 1 0
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 1
Glutamate receptor ionotropic, kainate 4 and Glutamate recepto... 1 3
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 4 4
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QM1E family 8 15
Adenosine receptor A2a and Adenosine receptor A2b ligand SureC... 2 2
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand SureC... 1 0
Melanin-concentrating hormone receptor 1 ligand SureCN3334191 ... 4 7
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 0
Tyrosine-protein kinase ITK/TSK and Receptor-type tyrosine-pro... 1 0
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 15 7
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1801305 ... 2 0
Mitogen-activated protein kinase 14 inhibitor N-ethyl-5-methyl... 17 3
Histone deacetylase 1 inhibitor (E)-N-hydroxy-3-[4-[[2-(1H-pyr... 2 8
Coagulation factor X and Prothrombin inhibitor 2-carboxyindole... 2 8
Coagulation factor X inhibitor AGN-PC-0749BY family 5 9
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 14 2
Histamine H3 receptor and Potassium voltage-gated channel subf... 7 1
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 1
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 0
Histamine H3 receptor ligand SureCN2878688 family 8 1
Protein-tyrosine kinase 6 and KH domain-containing, RNA-bindin... 21 6
Coagulation factor X and Coagulation factor IX inhibitor 5-ami... 9 4
Histamine H1 receptor and Histamine H4 receptor ligand [4-[2-[... 1 1
Heat shock protein HSP 90-beta inhibitor N-[(9R)-4-(3H-imidazo... 1 0
MAP kinase-activated protein kinase 2 inhibitor 4-fluoro-N-[4-... 25 1
Coagulation factor X inhibitor SureCN8289965 family 4 5
Ribosomal protein S6 kinase alpha-3 inhibitor N-(3-ethylimidaz... 2 2
Delta-type opioid receptor ligand ethyl N-[3-[(R)-[4-[ethyl(me... 2 6
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 1 0
Mast/stem cell growth factor receptor Kit and Mitogen-activate... 4 2
Casein kinase II subunit alpha and Serine/threonine-protein ki... 1 5
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 3 4
Aurora kinase B and Aurora kinase A inhibitor 4-amino-N-[3-[[(... 5 3
Protein kinase C theta type and Leucine-rich repeat serine/thr... 1 1
Neuropeptide Y receptor type 5 ligand AGN-PC-07R6YQ family 7 7
Neuropeptide Y receptor type 5 ligand SureCN4170426 family 4 13
Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[5... 4 11
Vascular endothelial growth factor receptor 2 ligand (3Z)-6-fl... 4 3
Platelet-derived growth factor receptor beta and Vascular endo... 5 12
Dipeptidyl peptidase 4 inhibitor 2-[[2-[(3R)-3-aminopiperidin-... 1 0
Glycogen synthase kinase-3 beta inhibitor N-[2-[4-(ethylsulfon... 3 1
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
Somatostatin receptor type 3 ligand tert-butyl 4-[(3R)-3-(5-ph... 2 2
Aurora kinase A and Aurora kinase B inhibitor 4-fluoro-N-[4-[(... 6 1
Activated CDC42 kinase 1 inhibitor N,N-dimethyl-4-[4-[[(2S)-ox... 3 0
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 2 0
Eukaryotic translation initiation factor 2-alpha kinase 3 inhi... 11 2
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 12 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 6
Serine/threonine-protein kinase Chk1 inhibitor SureCN5547496 f... 2 1
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 0
P2X purinoceptor 7 inhibitor SureCN113576 family 2 1
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 0
Melanocortin receptor 4 ligand AGN-PC-076AMO family 17 8
5-hydroxytryptamine receptor 2B ligand SureCN1299437 family 6 7
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor (3R)-... 4 12
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 10 1
Integrin beta-1 and Integrin alpha-4 inhibitor (5R)-5-[[(2R)-2... 2 3
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 8
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 4-[4... 1 1
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 3
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 1
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 3 0
RAF proto-oncogene serine/threonine-protein kinase and Serine/... 4 3
Metabotropic glutamate receptor 2 ligand 8-(2,5-difluorophenyl... 6 2
Mitogen-activated protein kinase 14 inhibitor 3-[(6-amino-1-ph... 9 2
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 3 0
Matrilysin and Stromelysin-1 inhibitor (2R)-N-[(1S)-1-(1H-benz... 3 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 5 1
Gonadotropin-releasing hormone receptor ligand SureCN3275214 f... 5 0
Cell division cycle 7-related protein kinase inhibitor Pyrrolo... 2 6
Epidermal growth factor receptor ligand (E)-5-[4-(3-bromoanili... 11 0
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Tyrosine-protein kinase ITK/TSK and Insulin receptor ligand AG... 5 1
Neuropeptide Y receptor type 5 ligand AGN-PC-077LX1 family 8 1
Aurora kinase A and Aurora kinase B inhibitor N-[(3E)-3-[5-(mo... 3 2
Melanin-concentrating hormone receptor 1 ligand SureCN3834858 ... 2 1
Egl nine homolog 1 inhibitor 2-[(1,6-diphenylimidazo[4,5-c]pyr... 1 5
Platelet-derived growth factor receptor beta and Fibroblast gr... 2 1
Tyrosine-protein kinase Lck inhibitor (3S)-3-[(1S)-1-[[4-(benz... 14 0
Mitogen-activated protein kinase 1 and Aurora kinase A inhibit... 16 3
Poly [ADP-ribose] polymerase 1 inhibitor 2-[4-(5-sulfanylidene... 1 1
LIM domain kinase 2 inhibitor 3-[[(cyanoamino)-[(2S)-2-methyl-... 6 0
Poly [ADP-ribose] polymerase 1 and Poly [ADP-ribose] polymeras... 4 0
Neuropeptide Y receptor type 5 ligand SureCN8149543 family 1 0
Tyrosine-protein kinase Lck and Tyrosine-protein kinase Lyn in... 1 0
Mitogen-activated protein kinase kinase kinase 5 inhibitor 4-(... 2 0
Fatty acid synthase inhibitor 4-[1-[2,4-dimethyl-5-(6-methylsu... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00410396 CHEMBL2160078 Bioactive N-[4-methyl-3-(5-phenyl-1H-imidazol-2-yl)phenyl]-4-morpholin-4-ylbenzamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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