CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11569
Family Name Aurora kinase B and Aurora kinase A inhibitor AGN-PC-09QXA7 family
No. of Seeds 16 No. of Other Members 0
Family Centroid CFAMM00410460 Functional Category Bioactive
Superfamily Tyrosine-protein kinase Lck and Aurora kinase B Inhibitor VX-680 Superfamily
Class Class 935

Cousin Family NamesSeedsMembers
Tyrosine-protein kinase Lck and Aurora kinase B Inhibitor VX-6... 28 56
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
RAC-gamma serine/threonine-protein kinase Inhibitor BMS-754807... 20 90
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 3 12
Platelet-activating factor receptor ligand SureCN9384429 family 11 3
Adenosine receptor A1 and Adenosine receptor A2a ligand 2-(4-a... 8 11
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QM1E family 8 15
Aurora kinase A inhibitor AGN-PC-0A9UUA family 4 1
Aurora kinase B and Aurora kinase A inhibitor 2-[(3S,4S)-3-hyd... 22 5
Aurora kinase B and Aurora kinase A inhibitor 2-[(3S,4S)-3-(2-... 4 0
Protein-tyrosine kinase 6 and KH domain-containing, RNA-bindin... 21 6
Casein kinase II subunit alpha inhibitor N-[5-[[3-cyano-7-(cyc... 3 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 1
Casein kinase II subunit alpha inhibitor N-[5-[[3-cyano-7-[(1-... 9 0
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 11 1
Insulin-like growth factor 1 receptor and G1/S-specific cyclin... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00410470 CHEMBL2163403 Bioactive N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]-2-[(3R)-3-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl]acetamide
CFAMM00410463 CHEMBL2163394 Bioactive (3R)-N-cyclopentyl-1-[2-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylanilino]-2-oxoethyl]pyrrolidine-3-carboxamide
CFAMM00410469 CHEMBL2163401 Bioactive 2-[(3R)-3-tert-butylsulfonylpyrrolidin-1-yl]-N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]acetamide
CFAMM00410462 CHEMBL2163392 Bioactive (3R)-1-[2-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylanilino]-2-oxoethyl]-N-(2-morpholin-4-ylethyl)pyrrolidine-3-carboxamide
CFAMM00410468 CHEMBL2163400 Bioactive 2-[(3R)-3-tert-butylsulfinylpyrrolidin-1-yl]-N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]acetamide
CFAMM00410461 CHEMBL2163390 Bioactive N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]-2-[(3R)-3-(morpholine-4-carbonyl)pyrrolidin-1-yl]acetamide
CFAMM00410467 CHEMBL2163387 Bioactive (3R)-N-tert-butyl-1-[2-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylanilino]-2-oxoethyl]pyrrolidine-3-carboxamide
CFAMM00410460 CHEMBL2163398 Bioactive AGN-PC-09QXA7
CFAMM00410466 CHEMBL2163388 Bioactive (3R)-1-[2-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylanilino]-2-oxoethyl]-N-(2,2,2-trifluoroethyl)pyrrolidine-3-carboxamide
CFAMM00410465 CHEMBL2163391 Bioactive 2-[(3R)-3-(4-hydroxypiperidine-1-carbonyl)pyrrolidin-1-yl]-N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]acetamide
CFAMM00410471 CHEMBL2163404 Bioactive 2-[(3R)-3-(3,3-difluoropyrrolidine-1-carbonyl)pyrrolidin-1-yl]-N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]acetamide
CFAMM00410464 CHEMBL2163395 Bioactive (3R)-N-cyclobutyl-1-[2-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylanilino]-2-oxoethyl]pyrrolidine-3-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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