CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11572
Family Name Cathepsin K inhibitor (1R,2R)-2-(6-chloro-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carbonyl)-N-(1-cyanocyclopropyl)cyclohexane-1-carboxamide family
No. of Seeds 2 No. of Other Members 0
Family Centroid CFAMM00410485 Functional Category Bioactive
Superfamily Cathepsin K and Cathepsin B Binder Superfamily
Class Class 173

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
Glycogen phosphorylase, muscle form Inhibitor PSN357 Family 3 253
Receptor-type tyrosine-protein kinase FLT3 Inhibitor SU5614 Fa... 4 36
Poly [ADP-ribose] polymerase 1 Inhibitor AG-14699 Family 13 179
Reverse transcriptase Inhibitor IDX899 Family 2 118
Growth hormone receptor Ligand EP-51216 Family 34 390
Histone deacetylase 1 Inhibitor Panobinostat Family 5 93
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
14-alpha sterol demethylase Inhibitor CP-320626 Family 13 76
Adenosine receptor A3 and Potassium voltage-gated channel subf... 1 18
Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... 12 160
Substance-P receptor ligand AGN-PC-01ZIXQ family 13 42
Huntingtin and Glycogen synthase kinase-3 beta inhibitor SB 21... 2 4
Gonadotropin-releasing hormone receptor ligand 5-[2-[[(2S)-2-[... 7 58
Cannabinoid receptor 1 ligand AGN-PC-04YSUM family 7 6
Melatonin receptor type 1A and Melatonin receptor type 1C liga... 2 5
cGMP-specific 3',5'-cyclic phosphodiesterase and Dual 3',5'-cy... 4 129
Ceramide glucosyltransferase inhibitor AGN-PC-07YS0C family 4 3
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 3 2
Melanin-concentrating hormone receptor 2 and Sodium-dependent ... 2 1
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-009GH... 8 10
Cathepsin K and Cathepsin B inhibitor (1R,2R)-N-(1-cyanocyclop... 10 7
Cathepsin K inhibitor (1R,2R)-N-(1-cyanocyclopropyl)-2-(6-meth... 1 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN5547533 f... 3 2
Gonadotropin-releasing hormone receptor ligand 1-adamantyl-[2-... 3 1
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 3 5
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 3 8
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 4 11
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 2 0
C-X-C chemokine receptor type 2 and Cytochrome P450 2C9 ligand... 1 7
Poly [ADP-ribose] polymerase 1 inhibitor SureCN4998361 family 1 1
Translocator protein inhibitor N,N-dibutyl-2-(7-chloro-2-pheny... 3 1
Malate dehydrogenase, mitochondrial inhibitor AGN-PC-0796ZJ fa... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00410485 CHEMBL2163582 Bioactive (1R,2R)-2-(6-chloro-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carbonyl)-N-(1-cyanocyclopropyl)cyclohexane-1-carboxamide
CFAMM00410484 CHEMBL2164687 Bioactive (1R,2R)-2-(8-chloro-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carbonyl)-N-(1-cyanocyclopropyl)cyclohexane-1-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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