CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11578
Family Name Endothelin-1 receptor and Endothelin B receptor ligand 6-[2-(5-bromopyrimidin-2-yl)oxyethoxy]-5-(2-chloro-5-methoxyphenoxy)-N-(propylsulfamoyl)pyrimidin-4-amine family
No. of Seeds 3 No. of Other Members 1
Family Centroid CFAMM00410531 Functional Category Bioactive
Superfamily Endothelin-1 receptor and Endothelin B receptor Binder Superfamily 16
Class Class 1208

Cousin Family NamesSeedsMembers
Endothelin B receptor and Endothelin-1 receptor ligand pyrimid... 22 180
Macitentan family 18 1
Deoxycytidine kinase inhibitor AGN-PC-07Z9C8 family 5 3
Endothelin-1 receptor and Endothelin B receptor ligand SureCN7... 17 3
5-hydroxytryptamine receptor 1A and Alpha-1D adrenergic recept... 4 2
Endothelin-1 receptor and Endothelin B receptor ligand 6-[2-(5... 7 0
Endothelin-1 receptor and Endothelin B receptor ligand N-(benz... 4 0


External ID

Functional Category

Molecule Name

CFAMM00410533 CHEMBL2165330 Bioactive N-(benzylsulfamoyl)-6-[2-(5-bromopyrimidin-2-yl)oxyethoxy]-5-(2-chloro-5-methoxyphenoxy)pyrimidin-4-amine
CFAMM00410531 CHEMBL2163692 Bioactive 6-[2-(5-bromopyrimidin-2-yl)oxyethoxy]-5-(2-chloro-5-methoxyphenoxy)-N-(propylsulfamoyl)pyrimidin-4-amine
CFAMM00410530 CHEMBL2163691 Bioactive 6-[2-(5-bromopyrimidin-2-yl)oxyethoxy]-5-(3-methoxyphenoxy)-N-(propylsulfamoyl)pyrimidin-4-amine

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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Computer-aided Drug Design
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