CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1158
Family Name Corticotropin-releasing factor receptor 1 ligand 3,7-dimethyl-5-pentan-3-yl-2-(2,4,5-trimethylphenyl)pyrrolo[1,2-b]pyridazine family
No. of Seeds 3 No. of Other Members 4
Family Centroid CFAMM00320188 Functional Category Bioactive
Superfamily Cathepsin S and Metabotropic glutamate receptor 5 Binder Superfamily
Class Class 2102

Cousin Family NamesSeedsMembers
Acetylcholinesterase Inhibitor Tacrine Family 12 515
Histamine H1 receptor Ligand Triprolidine Family 19 316
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
D(1B) dopamine receptor Ligand LE-300 Family 65 452
D(4) dopamine receptor Ligand Fauc 113 Family 14 96
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
TGF-beta receptor type-1 Ligand 4-(3-pyridin-2-yl-1h-pyrazol-4... 3 63
TGF-beta receptor type-1 Ligand Naphthyridine Inhibitor Family 3 6
Histamine H3 receptor Ligand 2-(4-isopropyl-piperazin-1-yl)-qu... 17 29
Metabotropic glutamate receptor 5 Ligand 3-(3-pyridin-2-yl-pyr... 4 24
Metabotropic glutamate receptor 5 Ligand 2-methyl-6-(4-phenylb... 6 32
D(2) dopamine receptor and D(3) dopamine receptor Ligand 1-(4-... 10 48
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... 8 11
Kappa-type opioid receptor and Potassium voltage-gated channel... 10 10
Indoleamine 2,3-dioxygenase 1 Inhibitor 4-(1h-1,2,3-triazol-5-... 3 12
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 1 3
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Metabotropic glutamate receptor 5 Ligand 3-fluoro-5-(2-methylq... 3 2
Metabotropic glutamate receptor 5 Ligand 3-chloro-5-(2-methylq... 3 4
Metabotropic glutamate receptor 5 Ligand 3-m-tolyl-1,5-naphthy... 6 10
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Histamine H3 receptor and Potassium voltage-gated channel subf... 2 2
Histamine H3 receptor and Potassium voltage-gated channel subf... 4 33
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 3
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 2
Corticotropin-releasing factor receptor 1 ligand AGN-PC-074YT9... 28 20
Corticotropin-releasing factor receptor 1 ligand AGN-PC-074YUB... 2 0
Smoothened homolog inhibitor AC1P6IWE family 1 0
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-00AP1L ... 14 7
Histone deacetylase 1 inhibitor (E)-N-hydroxy-3-[4-[[2-(2-meth... 7 9
Androgen receptor ligand 2-chloro-4-[4-[(4-fluorophenyl)methyl... 2 11
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 1
D(4) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 1
Glucocorticoid receptor ligand 6-benzyl-1-(4-fluorophenyl)-4a-... 2 0
Corticotropin-releasing factor receptor 1 ligand SureCN7215846... 4 1
Progesterone receptor ligand AGN-PC-00OK6G family 7 8
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 1 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 4-[6-... 3 3
Sigma non-opioid intracellular receptor 1 ligand 1-phenyl-4-(2... 1 0
Progesterone receptor ligand AGN-PC-074LWG family 1 1
Serine/threonine-protein kinase B-raf and Mitogen-activated pr... 16 5
Serine/threonine-protein kinase B-raf and RAF proto-oncogene s... 10 2
Heat shock protein HSP 90-beta inhibitor 1-[1-(naphthalen-2-yl... 3 2
Potassium voltage-gated channel subfamily H member 2 ligand 1-... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00320187 CHEMBL112264 Bioactive AGN-PC-074YTZ
CFAMM00320190 CHEMBL1939572 Bioactive 2-(2,4-dimethylphenyl)-3,7-dimethyl-5-pentan-3-ylpyrrolo[1,2-b]pyridazine
CFAMM00320188 CHEMBL1939573 Bioactive 3,7-dimethyl-5-pentan-3-yl-2-(2,4,5-trimethylphenyl)pyrrolo[1,2-b]pyridazine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27511 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543