CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11586
Family Name Cyclin-dependent kinase 2 and MAP kinase-activated protein kinase 2 inhibitor 5-N-(4-aminocyclohexyl)-3-chloro-7-N-(3-chloro-4-fluorophenyl)pyrazolo[1,5-a]pyrimidine-5,7-diamine family
No. of Seeds 3 No. of Other Members 0
Family Centroid CFAMM00410547 Functional Category Bioactive
Superfamily D(4) dopamine receptor Ligand L-745,870 Superfamily
Class Class 1567

Cousin Family NamesSeedsMembers
Omega 1 Benzodiazepine receptor Ligand Zaleplon Family 6 589
C-reactive protein Inhibitor ISIS-CRP Family 4 105
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Corticotropin-releasing factor receptor 1 Ligand Dmp-695/696 F... 11 20
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
Aurora kinase B and Tyrosine-protein kinase Lck Inhibitor CGP-... 2 29
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 3 63
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 8 7
Adenosine receptor A3 ligand AGN-PC-07N4XX family 6 10
Aurora kinase B inhibitor AGN-PC-07ZZ0Y family 2 12
Aurora kinase A and Aurora kinase B inhibitor 3uol family 6 5
Tyrosine-protein kinase JAK2 inhibitor N-[2-(3-chlorophenyl)-5... 2 11
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 7 9
Prelamin-A/C inhibitor CHEMBL1472945 family 1 32
Nuclear receptor ROR-gamma and 15-hydroxyprostaglandin dehydro... 1 1
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 7
Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta ... 2 3
Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta ... 3 1
Nociceptin receptor and Potassium voltage-gated channel subfam... 10 1
Aurora kinase A and Cyclin-dependent kinase 1 inhibitor N-[4-[... 12 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 11
Adenosine receptor A3 and Adenosine receptor A1 ligand CHEMBL1... 7 4
TGF-beta receptor type-1 ligand 3-(6-methylpyridin-2-yl)-N-phe... 21 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 1
Casein kinase II subunit alpha inhibitor AGN-PC-0766PM family 4 0
Vasopressin V1a receptor and Vasopressin V2 receptor ligand 8-... 6 2
Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta ... 3 3
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 9 2
Mast/stem cell growth factor receptor Kit and Receptor-type ty... 8 3
Vascular endothelial growth factor receptor 1 and Vascular end... 4 0
Casein kinase II subunit alpha and Homeodomain-interacting pro... 5 0
Casein kinase II subunit alpha inhibitor N-[5-[[3-cyano-7-(cyc... 3 0
D(4) dopamine receptor and Alpha-1D adrenergic receptor ligand... 3 3
Sigma non-opioid intracellular receptor 1 ligand 1-(3,4-dichlo... 2 19
Tyrosine-protein kinase JAK2 inhibitor N-[3-(3-chlorophenyl)-1... 12 4
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 0
Casein kinase II subunit alpha inhibitor 2pvj family 3 1
Epithelial discoidin domain-containing receptor 1 and Mast/ste... 1 0
Tyrosine-protein kinase ABL1 and Proto-oncogene tyrosine-prote... 2 8
Casein kinase II subunit alpha inhibitor N-[2-chloro-5-[[3-cya... 2 0
Casein kinase II subunit alpha inhibitor N-[5-[[3-cyano-7-(cyc... 9 0
Cytochrome P450 3A4 and Cytochrome P450 2C8 inhibitor N-[3-[(1... 1 0
Adenosine receptor A1 and Adenosine receptor A2b ligand SureCN... 2 3
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 4 3
Activated CDC42 kinase 1 inhibitor AGN-PC-078WDN family 7 2
Tyrosine-protein kinase ABL1 and Proto-oncogene tyrosine-prote... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00410549 CHEMBL2163995 Bioactive 5-N-(4-aminocyclohexyl)-3-bromo-7-N-(3-chloro-4-fluorophenyl)pyrazolo[1,5-a]pyrimidine-5,7-diamine
CFAMM00410548 CHEMBL2163997 Bioactive 5-[(4-aminocyclohexyl)amino]-7-(3-chloro-4-fluoroanilino)pyrazolo[1,5-a]pyrimidine-3-carbonitrile
CFAMM00410547 CHEMBL2163996 Bioactive 5-N-(4-aminocyclohexyl)-3-chloro-7-N-(3-chloro-4-fluorophenyl)pyrazolo[1,5-a]pyrimidine-5,7-diamine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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