CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11614
Family Name Bombesin receptor subtype-3 and Nuclear receptor subfamily 1 group I member 2 ligand 6-(4-tert-butylphenyl)sulfonyl-7,8-dimethyl-2-(trifluoromethyl)-5,11-dihydropyrido[3,2-c][1,5]benzodiazepine family
No. of Seeds 12 No. of Other Members 11
Family Centroid CFAMM00410648 Functional Category Bioactive
Superfamily Bombesin receptor subtype-3 and Nuclear receptor subfamily 1 group I member 2 Binder Superfamily
Class Class 122

Cousin Family NamesSeedsMembers
Corticosteroid 11-beta-dehydrogenase isozyme 1 Inhibitor 2-(4-... 8 25
Corticosteroid 11-beta-dehydrogenase isozyme 1 Inhibitor PF-91... 8 14
Beta-3 adrenergic receptor and Beta-2 adrenergic receptor liga... 4 1
Coagulation factor X and Trypsin-1 inhibitor SureCN3836037 family 5 4
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (2R)-... 5 10
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor 4-[2-(... 2 6
Glucose-dependent insulinotropic receptor ligand AGN-PC-0A9QCI... 2 6
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 15 3
Bombesin receptor subtype-3 ligand 2-[3-[6-(4-tert-butylphenyl... 7 1
Bombesin receptor subtype-3 and Nuclear receptor subfamily 1 g... 3 0
Bombesin receptor subtype-3 ligand 7,8-dimethyl-2-(trifluorome... 1 0
Bombesin receptor subtype-3 ligand 6-(4-tert-butylphenyl)sulfo... 3 0
Bombesin receptor subtype-3 ligand 2-[6-(4-tert-butylphenyl)su... 2 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 4-(4-... 1 1


External ID

Functional Category

Molecule Name

CFAMM00410655 CHEMBL2179477 Bioactive 6-[4-(2-fluoropropan-2-yl)phenyl]sulfonyl-7,8-dimethyl-2-(trifluoromethyl)-5,11-dihydropyrido[3,2-c][1,5]benzodiazepine
CFAMM00410648 CHEMBL2164575 Bioactive 6-(4-tert-butylphenyl)sulfonyl-7,8-dimethyl-2-(trifluoromethyl)-5,11-dihydropyrido[3,2-c][1,5]benzodiazepine
CFAMM00410641 CHEMBL2179913 Bioactive 6-(4-tert-butylphenyl)sulfonyl-8-methyl-2-(trifluoromethyl)-5,11-dihydropyrido[3,2-c][1,5]benzodiazepine
CFAMM00410647 CHEMBL2179484 Bioactive 6-(4-tert-butylphenyl)sulfonyl-2,7,8-trimethyl-5,11-dihydropyrido[3,2-c][1,5]benzodiazepine
CFAMM00410646 CHEMBL2164578 Bioactive 6-(4-tert-butylphenyl)sulfonyl-7-piperidin-4-yl-2-(trifluoromethyl)-5,11-dihydropyrido[3,2-c][1,5]benzodiazepine
CFAMM00410659 CHEMBL2179478 Bioactive 2-[4-[[7,8-dimethyl-2-(trifluoromethyl)-5,11-dihydropyrido[3,2-c][1,5]benzodiazepin-6-yl]sulfonyl]phenyl]-2-methylpropanenitrile
CFAMM00410639 CHEMBL2179911 Bioactive 6-(4-tert-butylphenyl)sulfonyl-7-methyl-2-(trifluoromethyl)-5,11-dihydropyrido[3,2-c][1,5]benzodiazepine
CFAMM00410652 CHEMBL2179907 Bioactive 6-(4-tert-butylphenyl)sulfonyl-7,8-dimethyl-5,11-dihydropyrido[3,2-c][1,5]benzodiazepine-2-carbonitrile
CFAMM00410658 CHEMBL2179473 Bioactive 7,8-dimethyl-6-(4-propan-2-ylphenyl)sulfonyl-2-(trifluoromethyl)-5,11-dihydropyrido[3,2-c][1,5]benzodiazepine
CFAMM00410644 CHEMBL2179914 Bioactive 6-(4-tert-butylphenyl)sulfonyl-2-(trifluoromethyl)-5,11-dihydropyrido[3,2-c][1,5]benzodiazepine
CFAMM00410656 CHEMBL2179474 Bioactive 7,8-dimethyl-2-(trifluoromethyl)-6-[4-(trifluoromethyl)phenyl]sulfonyl-5,11-dihydropyrido[3,2-c][1,5]benzodiazepine

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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