CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11626
Family Name Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform and Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform inhibitor 4-[2-[(6-methoxypyridin-3-yl)amino]-5-(6-methylpyridin-3-yl)pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine family
No. of Seeds 3 No. of Other Members 0
Family Centroid CFAMM00292641 Functional Category Bioactive
Superfamily Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform and Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Binder Superfamily
Class Class 481

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Astemizole Family 7 240
Peptide deformylase, mitochondrial Inhibitor Trimetrexate Family 4 311
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Histamine H1 receptor Ligand Mepyramine Family 5 65
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Hypoxia-inducible factor 1-alpha Inhibitor Hif-1alpha Family 7 107
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Insulin-like growth factor 1 receptor Ligand AEW-541 Family 12 140
Receptor tyrosine-protein kinase erbB-2 Inhibitor TAK-285 Family 16 124
Corticotropin-releasing factor receptor 1 Ligand GW876008 Family 3 30
AP26113 family 16 90
SB1518 family 7 103
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 11 10
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
Ibrutinib family 2 27
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Tyrosine kinase Inhibitor PKI166 Family 17 198
Heat shock protein HSP 90-alpha Inhibitor 8-benzo[1,3]dioxol-,... 5 83
Peptide deformylase, mitochondrial Inhibitor 5-(4-methoxypheno... 5 61
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
Vascular endothelial growth factor receptor 2 Ligand L00002164... 6 23
cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor 7-et... 7 57
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-[3-(4-... 7 128
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Adenosine receptor A1 and Adenosine receptor A3 Ligand 2-(4-me... 3 23
Metabotropic glutamate receptor 5 Ligand (3-ethoxy-pyridin-2-y... 3 12
Glycogen synthase kinase-3 beta and Mitogen-activated protein ... 8 8
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 37
Platelet-derived growth factor receptor alpha and Fibroblast g... 3 47
Fatty-acid amide hydrolase 1 Inhibitor BMS-1 Family 5 22
Corticotropin-releasing factor receptor 1 Ligand BMS-561388 Fa... 10 16
Reverse transcriptase Inhibitor UK-129485 Family 23 221
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Metabotropic glutamate receptor 5 Ligand 7-(4,6-dimethoxypyrim... 2 0
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
Integrin beta-3 and Integrin alpha-V inhibitor methyl (3S)-3-(... 12 13
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 1 inhibi... 2 22
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 4
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Tyrosine-protein kinase Lck inhibitor 4-N-(2-chloro-6-methylph... 8 45
Serine/threonine-protein kinase B-raf inhibitor SureCN1015955 ... 17 18
Adenosine receptor A3 and Adenosine receptor A2a ligand AGN-PC... 3 4
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 1 15
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 2 6
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 28
Vascular endothelial growth factor receptor 2 and Angiopoietin... 2 11
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-072YMN ... 7 11
Serine/threonine-protein kinase B-raf inhibitor 3-[7-[4-[[(3R)... 6 7
Histamine H4 receptor ligand AGN-PC-07ZG9H family 4 4
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN97387... 4 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 11
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-072YXQ ... 2 1
Proto-oncogene tyrosine-protein kinase Src and Cyclin-dependen... 2 1
Adenosine receptor A3 ligand AGN-PC-07N4XZ family 4 11
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 7 16
Serine/threonine-protein kinase PLK1 and Serine/threonine-prot... 14 42
Adenosine receptor A3 ligand CHEMBL1834696 family 5 18
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 3
Tyrosine-protein kinase Lck inhibitor AGN-PC-073GX8 family 12 1
Lysine--tRNA ligase and Dual specificity protein kinase CLK4 i... 4 27
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 39 10
Corticotropin-releasing factor receptor 1 ligand AGN-PC-068CC4... 20 7
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Su... 2 16
Cathepsin S and Cathepsin K inhibitor SureCN1629664 family 10 11
Cathepsin S and Cathepsin K inhibitor AGN-PC-088VBO family 3 11
Adenosine kinase inhibitor 5-[3-(4-methoxyphenyl)propyl]-6-[2-... 2 11
Epidermal growth factor receptor and Cyclin-dependent kinase 1... 3 4
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 31 11
Heat shock protein HSP 90-alpha inhibitor 3-[2-amino-4-chloro-... 7 2
Serine/threonine-protein kinase Chk2 and Serine/threonine-prot... 3 6
Adenosine receptor A3 and Adenosine receptor A2a ligand 4-(5-b... 2 5
Tyrosine-protein kinase ABL1 and Tyrosine-protein kinase HCK i... 2 2
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 9 19
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Vascular endothelial growth factor receptor 2 ligand AGN-PC-09... 5 11
Glucocorticoid receptor ligand (2R)-1,1,1-trifluoro-4-(2-metho... 2 5
Casein kinase I isoform delta and Mitogen-activated protein ki... 3 18
Vascular endothelial growth factor receptor 2 ligand F3284-701... 1 2
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 19 11
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 8 12
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 3
Melatonin receptor type 1A ligand N-[2-(5-methoxy-2-phenyl-1H-... 1 2
Cellular tumor antigen p53 inhibitor CHEMBL1401545 family 1 25
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN7... 3 0
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 14
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Dual specificity tyrosine-phosphorylation-regulated kinase 1A ... 3 20
D(3) dopamine receptor and D(2) dopamine receptor ligand 2-[4-... 2 3
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Dihydrofolate reductase inhibitor AC1LA5HU family 8 4
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 3
Dihydrofolate reductase inhibitor AC1L9XPA family 6 5
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
Epidermal growth factor receptor ligand Pyrimido[4,5-b]indole ... 1 4
Lethal factor and Dual specificity protein kinase CLK4 inhibit... 1 3
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 6
Tyrosine-protein kinase JAK2 inhibitor 5-(3-methoxyphenyl)-N-[... 2 11
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 0
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 6
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QJGR family 3 13
Neuropeptide Y receptor type 5 ligand 3-[2-[6-[2-[(2-methylpro... 1 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 5
Prostaglandin D2 receptor ligand 2-[3-[2-methoxy-6-[2-(4-metho... 4 12
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 2 5
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
Adenosine receptor A3 ligand AGN-PC-08WSLM family 5 22
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 6 12
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 17
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 5 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 5 4
Ephrin type-B receptor 4 ligand SureCN5131922 family 4 0
Ephrin type-B receptor 4 and Vascular endothelial growth facto... 2 0
Cholecystokinin receptor type A ligand AGN-PC-0A9ULH family 8 8
Calmodulin-domain protein kinase 1 and Tyrosine-protein kinase... 5 5
Melatonin receptor type 1B ligand CHEMBL1802020 family 2 7
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 9 10
Insulin receptor and Insulin-like growth factor 1 receptor lig... 17 7
Insulin-like growth factor 1 receptor and Potassium voltage-ga... 2 2
Dual specificity protein kinase TTK inhibitor 6-N-cyclohexyl-2... 3 1
Corticotropin-releasing factor receptor 1 ligand CHEMBL1819076... 2 0
Tyrosine-protein kinase JAK2 inhibitor (2S)-1-[4-[4-[[7-(2-met... 11 27
ALK tyrosine kinase receptor and Nucleophosmin ligand N-[2-met... 8 0
Corticotropin-releasing factor receptor 1 ligand 5-N-(2-chloro... 7 1
Corticotropin-releasing factor receptor 1 ligand CHEMBL1830528... 1 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 2
Acyl-CoA desaturase 1 and Acyl-CoA desaturase inhibitor 2-[4-[... 2 6
TGF-beta receptor type-1 ligand N-(4-methoxyphenyl)-3-(6-methy... 5 2
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 1 3
Toll-like receptor 7 ligand 4-amino-1-[[6-(2-pyrrolidin-1-ylet... 2 5
Corticotropin-releasing factor receptor 1 ligand N-(dicyclopro... 5 1
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 7 2
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 4 2
Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta ... 1 0
Cathepsin K and Cathepsin L1 inhibitor CHEBI:43424 family 2 0
Corticotropin-releasing factor receptor 1 ligand Pyridopyrazin... 2 1
Corticotropin-releasing factor receptor 1 ligand AGN-PC-009TSL... 3 3
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 4 9
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 7 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 10 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 0
cGMP-specific 3',5'-cyclic phosphodiesterase and Rod cGMP-spec... 42 3
cGMP-specific 3',5'-cyclic phosphodiesterase and Rod cGMP-spec... 24 5
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 5 7
Tyrosine-protein kinase JAK2 and Focal adhesion kinase 1 inhib... 3 1
ALK tyrosine kinase receptor and Nucleophosmin ligand N-[2-met... 8 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 2
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 5 8
Hepatocyte growth factor receptor and Cytochrome P450 3A4 liga... 5 2
Interleukin-1 receptor-associated kinase 4 and Interleukin-1 r... 4 0
Insulin-like growth factor 1 receptor ligand 4-(2,3-dihydroind... 1 0
Adenosine kinase inhibitor (2R,3R,4R)-2-[4-(2,3-dihydro-1,4-be... 5 2
Macrophage colony-stimulating factor 1 receptor and Ephrin typ... 1 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 8 1
Mitogen-activated protein kinase 14 inhibitor AGN-PC-075YQ1 fa... 4 0
Rho-associated protein kinase 1 and cAMP-dependent protein kin... 1 11
Serine/threonine-protein kinase B-raf and RAF proto-oncogene s... 1 0
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 8 6
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 6
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-07... 1 0
Dual specificity protein kinase TTK inhibitor 6-N-cyclohexyl-2... 12 2
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Vascular endothelial growth factor receptor 2 and Vascular end... 4 2
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 7 16
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 9
Lysine--tRNA ligase inhibitor 4-[[[2-(2-piperazin-1-ylpyridin-... 2 1
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 25 2
Activated CDC42 kinase 1 inhibitor 5-(2-fluorophenyl)-N-[[(2S)... 5 0
Fibroblast growth factor receptor 1 and Vascular endothelial g... 3 0
Transient receptor potential cation channel subfamily V member... 6 2
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 2
Vasopressin V1a receptor and Vasopressin V2 receptor ligand 1-... 8 6
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 6 13
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
ALK tyrosine kinase receptor and Nucleophosmin ligand N-[2-[2-... 5 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 18 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Eukaryotic translation initiation factor 2-alpha kinase 3 inhi... 1 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Beta-secretase 1 and Beta-secretase 2 inhibitor 7-fluoro-3-(5-... 2 7
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
Nitric oxide synthase, inducible inhibitor SureCN5194847 family 24 48
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 1
Glucose-dependent insulinotropic receptor ligand 2-[1-(5-ethyl... 2 1
Tyrosine-protein kinase Lck inhibitor 3-[[2-(benzimidazol-1-yl... 2 0
Metabotropic glutamate receptor 2 ligand 8-chloro-3-(cycloprop... 6 2
CGMP-dependent protein kinase inhibitor 1-[2-(4-fluorophenyl)-... 1 4
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 3 14
Transient receptor potential cation channel subfamily V member... 2 4
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4463897 f... 3 2
TRAF2 and NCK-interacting protein kinase inhibitor 4-methoxy-3... 4 1
Mast/stem cell growth factor receptor Kit and Epithelial disco... 3 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 5
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
Receptor-type tyrosine-protein kinase FLT3 and Vascular endoth... 2 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 5 0
Aromatase inhibitor 2-(imidazol-1-ylmethyl)-6-methoxy-1-phenyl... 2 8
Motilin receptor ligand SureCN2012437 family 4 0
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 0
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
cGMP-dependent 3',5'-cyclic phosphodiesterase inhibitor SureCN... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 12 2
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 2
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
G1/S-specific cyclin-E1 and Cyclin-dependent kinase 2 inhibito... 1 4
Tyrosine-protein kinase JAK2 inhibitor (2R)-2-[4-[[8-(4-methox... 2 0
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 5
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand pheny... 1 0
Vascular endothelial growth factor receptor 2 and Angiopoietin... 3 3
Substance-P receptor ligand (2S,3S)-N-[[2-methoxy-5-(tetrazol-... 2 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 8-[(6,7... 6 8
Adenosine receptor A2a ligand 8-(3-fluorophenyl)-3-[2-[4-[4-(2... 5 0
Cyclin-dependent kinase 1 inhibitor N-[[5-[(3Z)-3-[4-(methoxym... 3 7
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 9 2
Melanin-concentrating hormone receptor 1 ligand SureCN5431614 ... 1 2
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
Melanin-concentrating hormone receptor 1 ligand (1S,3S)-3-N-(7... 2 2
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 6 2
Mitogen-activated protein kinase 14 inhibitor SureCN4913214 fa... 1 2
Leukotriene A-4 hydrolase inhibitor AGN-PC-00EW8S family 1 2
Histamine H1 receptor ligand N-[6-[2-[(4-methoxyphenyl)methyl-... 2 1
Dihydrofolate reductase inhibitor AC1LAPW3 family 3 0
Dihydrofolate reductase inhibitor AGN-PC-001U7R family 3 0
Vascular endothelial growth factor receptor 2 and Vascular end... 1 1
Dihydrofolate reductase and Dihydrofolate reductase type 1 inh... 8 1
Insulin-like growth factor 1 receptor ligand 3-[8-amino-1-(4-e... 9 0
Tyrosine-protein kinase Lck and Vascular endothelial growth fa... 1 0
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 5 1
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 4 1
Glucagon receptor ligand SureCN2647807 family 3 7
Cyclin-dependent kinase 1 inhibitor AGN-PC-075VQQ family 2 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
Adenosine receptor A3 and Adenosine receptor A1 ligand N-[2-(4... 3 2
Cyclin-dependent kinase 1 and Receptor tyrosine-protein kinase... 2 3
Glycogen synthase kinase-3 beta and Glycogen synthase kinase-3... 4 4
Cholecystokinin receptor type A ligand AGN-PC-077L8J family 22 2
Activated CDC42 kinase 1 and Tyrosine-protein kinase Lck inhib... 4 0
Rho-associated protein kinase 2 inhibitor SureCN1519463 family 5 1
Oxytocin receptor and Vasopressin V1b receptor ligand AGN-PC-0... 1 1
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 7 5
Cathepsin S and Cathepsin K inhibitor 2-cyano-pyrropyrimidine,... 4 1
Oxytocin receptor and Vasopressin V1a receptor ligand AGN-PC-0... 4 3
Adenosine receptor A2a ligand AGN-PC-077RYH family 16 5
Metabotropic glutamate receptor 1 ligand AGN-PC-00FV3S family 2 0
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 8
Nociceptin receptor and Delta-type opioid receptor ligand 2-[3... 2 1
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 3 5
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 3 1
Epidermal growth factor receptor ligand Pyrido[3,4-d]pyrimidin... 3 1
D(2) dopamine receptor ligand AGN-PC-07C1V6 family 2 3
Oxytocin receptor ligand AGN-PC-07C71T family 3 2
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 7 6
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 26 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 12 0
Hepatocyte growth factor receptor and Potassium voltage-gated ... 1 0
LIM domain kinase 2 and LIM domain kinase 1 inhibitor SureCN36... 1 1
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-07CQG5 ... 2 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 0
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-07CR... 4 0
Glucokinase inhibitor AGN-PC-03ZE5E family 1 0
TGF-beta receptor type-1 ligand SureCN373216 family 3 14
Acyl-CoA desaturase 1 inhibitor Pyridazine, 3-[4-(2-ethylpheno... 4 2
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 7 4
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 1 0
Epidermal growth factor receptor ligand 4-Anilinoquinazoline d... 2 0
Corticotropin-releasing factor receptor 1 ligand N-[(1R,2S)-2-... 3 0
Acyl-CoA:cholesterol acyltransferase inhibitor SureCN8919280 f... 23 18
Proto-oncogene tyrosine-protein kinase Src and Fibroblast grow... 2 0
Serine/threonine-protein kinase PLK1 inhibitor SureCN3992071 f... 1 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 5 3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00410686 CHEMBL402361 Bioactive 6-[6-(6-methoxypyridin-3-yl)imidazo[1,2-a]pyridin-3-yl]-N-piperidin-4-ylpyridin-2-amine
CFAMM00410685 CHEMBL2165033 Bioactive 4-[2-[(6-methoxypyridin-3-yl)amino]-5-(1-methylpyrazol-4-yl)pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27295 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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