CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11627
Family Name Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform and Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform inhibitor 3-[[3-(4-amino-6-methyl-1,3,5-triazin-2-yl)pyridin-2-yl]amino]phenol family
No. of Seeds 1 No. of Other Members 1
Family Centroid CFAMM00192374 Functional Category Bioactive
Superfamily Epidermal growth factor receptor and Signal transducer Binder Superfamily
Class Class 1031

Cousin Family NamesSeedsMembers
Peptide deformylase, mitochondrial Inhibitor Trimetrexate Family 4 311
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Hypoxia-inducible factor 1-alpha Inhibitor Hif-1alpha Family 7 107
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 13
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Insulin-like growth factor 1 receptor Ligand AEW-541 Family 12 140
AP26113 family 16 90
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
Tyrosine kinase Inhibitor PKI166 Family 17 198
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 11 12
Glycogen synthase kinase-3 beta and Mitogen-activated protein ... 8 8
D(4) dopamine receptor Ligand A-425444 Family 2 10
Mitogen-activated protein kinase 8 Inhibitor 2-(2-phenoxypyrim... 12 30
Platelet-derived growth factor receptor alpha and Platelet-der... 3 18
Reverse transcriptase Inhibitor UK-129485 Family 23 221
Adenosine receptor A1 and Adenosine receptor A2a ligand NSC658... 8 54
Platelet-derived growth factor receptor beta and Platelet-deri... 2 19
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Serine/threonine-protein kinase B-raf inhibitor 3-[7-[4-[[(3R)... 6 7
Proto-oncogene tyrosine-protein kinase Src and Cyclin-dependen... 2 1
Tyrosine-protein kinase Lck inhibitor AGN-PC-073GX8 family 12 1
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 10
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 14
Dihydrofolate reductase inhibitor AC1LA5HU family 8 4
Adenosine receptor A1 and Adenosine receptor A2a ligand (6E)-6... 2 2
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 3
Dihydrofolate reductase inhibitor AC1L9XPA family 6 5
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Lethal factor and Dual specificity protein kinase CLK4 inhibit... 1 3
Methionine--tRNA ligase inhibitor SureCN7818124 family 1 9
Proto-oncogene tyrosine-protein kinase Src and Epidermal growt... 9 9
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 17
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 3
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 9 10
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 1 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 0
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 1 3
Insulin-like growth factor 1 receptor ligand 4-(2,3-dihydroind... 1 0
Wee1-like protein kinase and ALK tyrosine kinase receptor liga... 1 9
Glutamate receptor ionotropic, NMDA 2B and Glutamate receptor ... 4 11
Vascular endothelial growth factor receptor 2 and Vascular end... 4 2
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 7 16
Lysine--tRNA ligase inhibitor 4-[[[2-(2-piperazin-1-ylpyridin-... 2 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Tyrosine-protein kinase Lck inhibitor 3-[[2-(benzimidazol-1-yl... 2 0
Transient receptor potential cation channel subfamily V member... 2 4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 5
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 2
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
Ephrin type-A receptor 3 and Tyrosine-protein kinase Fgr ligan... 1 3
Tyrosine-protein kinase TXK and Tyrosine-protein kinase Lyn in... 1 1
Dihydrofolate reductase inhibitor AC1LAPW3 family 3 0
Dihydrofolate reductase inhibitor AGN-PC-001U7R family 3 0
Adenosine receptor A1 and Adenosine receptor A2a ligand 7-meth... 2 0
Transient receptor potential cation channel subfamily V member... 18 1
Vascular endothelial growth factor receptor 2 ligand pyrimidin... 2 2
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 8
Epidermal growth factor receptor ligand Pyrido[3,4-d]pyrimidin... 3 1
Aurora kinase A and Aurora kinase B inhibitor AGN-PC-071H3F fa... 3 0
LIM domain kinase 2 and LIM domain kinase 1 inhibitor SureCN36... 1 1
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 1 0
Epidermal growth factor receptor ligand 4-Anilinoquinazoline d... 2 0
cAMP-dependent protein kinase catalytic subunit beta and cAMP-... 1 0
Vascular endothelial growth factor receptor 2 and Serine/threo... 4 2
Vascular endothelial growth factor receptor 2 and Serine/threo... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

25238 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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