CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11651
Family Name Rho-associated protein kinase 1 inhibitor SureCN4007647 family
No. of Seeds 8 No. of Other Members 4
Family Centroid CFAMM00410787 Functional Category Bioactive with Natural Product
Superfamily GABA theta subunit and Rho-associated protein kinase 1 Binder Superfamily
Class Class 681

Cousin Family NamesSeedsMembers
Serine/threonine-protein kinase B-raf inhibitor diaryl urea an... 12 93
Gamma-secretase subunit APH-1B Inhibitor E2012 Family 3 67
Receptor tyrosine-protein kinase erbB-2 Inhibitor TAK-285 Family 16 124
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
MK-6096 family 3 69
RAC-gamma serine/threonine-protein kinase Inhibitor GSK690693 ... 16 27
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(3'-methoxyphenyl) ... 9 93
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
TGF-beta receptor type-1 Ligand SB-431542 Family 2 42
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Tyrosine-protein kinase Lyn and Tyrosine-protein kinase Lck in... 1 6
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 28
Adenosine receptor A3 ligand AGN-PC-07N4XZ family 4 11
Serine/threonine-protein kinase PLK1 and Serine/threonine-prot... 14 42
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 9 0
Lysine--tRNA ligase and Dual specificity protein kinase CLK4 i... 4 27
Glycogen synthase kinase-3 alpha and Casein kinase II subunit ... 1 16
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Vascular endothelial growth factor receptor 2 ligand AGN-PC-09... 5 11
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Thyroid hormone receptor beta and Cruzipain ligand CHEMBL14730... 1 12
Melanocortin receptor 4 ligand AGN-PC-076AML family 3 24
Histamine H3 receptor ligand SureCN7251693 family 3 1
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QJGR family 3 13
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-09ODY0 ... 2 5
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9RSG ... 6 5
Renin inhibitor [2-(2,6-dimethylphenoxy)-6-methoxy-1-phenylpyr... 1 0
Mitogen-activated protein kinase 14 inhibitor 3-fluoro-N-[4-me... 2 5
Cathepsin K and Cathepsin L1 inhibitor CHEBI:43424 family 2 0
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 5 7
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 3 0
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 12 13
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 10
Growth hormone secretagogue receptor type 1 ligand 2-methyl-6-... 2 0
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 2 8
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
Platelet-derived growth factor receptor alpha and Vascular end... 3 1
ALK tyrosine kinase receptor ligand 4-fluoro-N-[1-[4-(propan-2... 1 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
Vascular endothelial growth factor receptor 2 and Platelet-der... 16 11
Rho-associated protein kinase 1 inhibitor SureCN4716133 family 2 2
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 8
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 6
Vascular endothelial growth factor receptor 2 and Serine/threo... 6 13
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 3 5
Mast/stem cell growth factor receptor Kit and Epithelial disco... 3 0
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Glycogen synthase kinase-3 beta inhibitor 3-imidazo[1,2-a]pyri... 1 1
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[2-(die... 12 2
Vascular endothelial growth factor receptor 2 ligand AGN-PC-04... 8 1
Angiopoietin-1 receptor and Vascular endothelial growth factor... 5 0
Mast/stem cell growth factor receptor Kit and Serine/threonine... 11 29
Vasopressin V1a receptor and Vasopressin V2 receptor ligand AG... 2 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
Cannabinoid receptor 2 ligand AGN-PC-03LKW5 family 24 5
RAF proto-oncogene serine/threonine-protein kinase inhibitor a... 8 6
Glycogen synthase kinase-3 beta and Glycogen synthase kinase-3... 4 4
Insulin-like growth factor 1 receptor ligand SureCN311483 family 3 0
Cholecystokinin receptor type A ligand AGN-PC-077L8J family 22 2
Rho-associated protein kinase 2 inhibitor AGN-PC-078WHL family 3 1
Translocator protein inhibitor AGN-PC-04X3HY family 10 1
RAF proto-oncogene serine/threonine-protein kinase inhibitor a... 5 0
Cholecystokinin receptor type A ligand AGN-PC-077KXF family 2 0
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 8
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
Insulin-like growth factor 1 receptor ligand AGN-PC-07C5TC family 2 4
Delta-type opioid receptor and Kappa-type opioid receptor liga... 3 1
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 0
Dihydrofolate reductase inhibitor AGN-PC-073PP8 family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00410787 CHEMBL218870 Bioactive SureCN4007647
CFAMM00410793 CHEMBL426526 Bioactive SureCN4003702
CFAMM00410792 CHEMBL220465 Bioactive GSK248233A
CFAMM00410790 CHEMBL429700 Bioactive SureCN4002129
CFAMM00410789 CHEMBL220080 Bioactive SureCN3994133
CFAMM00410788 CHEMBL216574 Bioactive SureCN4004100
CFAMM00410794 CHEMBL376321 Bioactive SureCN4008472

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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