CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11653
Family Name Histone deacetylase 1 inhibitor N-hydroxy-5-[1-[2-[(1-methylindol-2-yl)methylamino]ethyl]pyrazol-3-yl]thiophene-2-carboxamide family
No. of Seeds 4 No. of Other Members 1
Family Centroid CFAMM00410799 Functional Category Bioactive
Superfamily Insulin receptor and Histone deacetylase 1 Binder Superfamily
Class Class 689

Cousin Family NamesSeedsMembers
Omega 1 Benzodiazepine receptor Ligand Indiplon Family 4 25
Vascular endothelial growth factor receptor 1 and Angiopoietin... 29 127
Macrophage metalloelastase Inhibitor PF-00356231 Family 5 79
Histone deacetylase 1 Inhibitor N-hydroxy-5-(pyridin-3-yl)thio... 9 46
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor lig... 2 8
Neutrophil collagenase and Stromelysin-1 inhibitor AGN-PC-073U... 3 8
Prostaglandin E2 receptor EP4 subtype ligand AGN-PC-09QJ7P family 2 0
Neuromedin-K receptor ligand 3-methylsulfinyl-N-[(1S)-1-phenyl... 3 5
Protein kinase C beta type and Protein kinase C delta type inh... 1 2
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 2 ... 1 2
Neuronal acetylcholine receptor subunit alpha-7 ligand AGN-PC-... 7 1
Rho-associated protein kinase 2 and Rho-associated protein kin... 2 6
Neuronal acetylcholine receptor subunit alpha-7 and Neuronal a... 8 5
Histone deacetylase 1 inhibitor 5-[1-[2-(3,5-difluoroanilino)-... 2 2
Histone deacetylase 1 inhibitor N-hydroxy-5-[1-[2-[(4-imidazol... 1 0
Histone deacetylase 1 inhibitor 5-[5-[[(2-chlorophenyl)methyla... 4 1
Vascular endothelial growth factor receptor 2 and Angiopoietin... 14 0
Angiopoietin-1 receptor and Vascular endothelial growth factor... 9 0
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 4 0
Nicotinamide phosphoribosyltransferase inhibitor N-[[4-(benzen... 4 4
D(3) dopamine receptor and D(4) dopamine receptor ligand AGN-P... 2 0
Histone deacetylase 1 inhibitor N-hydroxy-5-[1-(2-phenylmethox... 1 0
Histone deacetylase 8 and Histone deacetylase 6 inhibitor N-ox... 2 0


External ID

Functional Category

Molecule Name

CFAMM00410805 CHEMBL218511 Bioactive N-hydroxy-5-[1-[2-(1H-indol-5-ylmethylamino)ethyl]pyrazol-3-yl]thiophene-2-carboxamide
CFAMM00410803 CHEMBL386473 Bioactive N-hydroxy-5-[1-[2-oxo-2-(quinolin-8-ylamino)ethyl]pyrazol-3-yl]thiophene-2-carboxamide
CFAMM00410799 CHEMBL216625 Bioactive N-hydroxy-5-[1-[2-[(1-methylindol-2-yl)methylamino]ethyl]pyrazol-3-yl]thiophene-2-carboxamide
CFAMM00410798 CHEMBL217004 Bioactive N-hydroxy-5-[1-[2-[(4-pyridin-2-ylphenyl)methylamino]ethyl]pyrazol-3-yl]thiophene-2-carboxamide

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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