CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11659
Family Name Cholinesterase and Acetylcholinesterase inhibitor 6-[2-methoxy-4-[(E)-3-oxo-3-[8-(1,2,3,4-tetrahydroacridin-9-ylamino)octylamino]prop-1-enyl]phenoxy]hexyl nitrate family
No. of Seeds 12 No. of Other Members 6
Family Centroid CFAMM00377532 Functional Category Bioactive
Superfamily Acetylcholinesterase and Butyrylcholinesterase Binder Superfamily 2
Class Class 24

Cousin Family NamesSeedsMembers
DNA Binder Primaquine Family 3 245
Sodium channel protein type 5 subunit alpha Ligand Dibucaine F... 2 136
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Phospholipase A2 Inhibitor Quinacrine Family 13 95
Multidrug resistance protein Inhibitor Tariquidar Family 3 60
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
Platelet-derived growth factor receptor alpha and Platelet-der... 2 17
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Adenosine receptor A1 and Adenosine receptor A3 Ligand 4-metho... 1 16
Melanin-concentrating hormone receptor 1 Ligand Gnf-pf-2322 Fa... 3 95
Neuromedin-K receptor Ligand 3-methoxy-n',2-diphenylquinoline-... 14 33
Melanin-concentrating hormone receptor 1 and Cytochrome P450 3... 8 2
Hypoxia-inducible factor 1-alpha and Lethal factor inhibitor C... 1 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(1,3-... 2 9
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 7 4
Butyrylcholinesterase and Acetylcholinesterase inhibitor AGN-P... 9 24
Adenosine receptor A1 and Adenosine receptor A3 ligand AGN-PC-... 6 8
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-09Q7W... 7 3
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Disintegrin and metalloproteinase domain-containing protein 17... 13 3
Disintegrin and metalloproteinase domain-containing protein 17... 16 2
Acetylcholinesterase and Butyrylcholinesterase inhibitor (E)-3... 4 5
Cholinesterase and Acetylcholinesterase inhibitor tacrine deri... 10 0
Cholinesterase and Acetylcholinesterase inhibitor 6-[4-[2-fluo... 17 0
D(1A) dopamine receptor and D(2) dopamine receptor ligand (6aR... 3 6
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 2
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-077PI... 4 0
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-077PJ... 4 4
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00410842 CHEMBL2171315 Bioactive 4-[2-methoxy-4-[(E)-3-oxo-3-[3-(1,2,3,4-tetrahydroacridin-9-ylamino)propylamino]prop-1-enyl]phenoxy]butyl nitrate
CFAMM00410835 CHEMBL2171323 Bioactive 4-[2-methoxy-4-[(E)-3-oxo-3-[6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexylamino]prop-1-enyl]phenoxy]butyl nitrate
CFAMM00410834 CHEMBL2171322 Bioactive 3-[2-methoxy-4-[(E)-3-oxo-3-[6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexylamino]prop-1-enyl]phenoxy]propyl nitrate
CFAMM00410839 CHEMBL2171325 Bioactive 2-[2-methoxy-4-[(E)-3-oxo-3-[8-(1,2,3,4-tetrahydroacridin-9-ylamino)octylamino]prop-1-enyl]phenoxy]ethyl nitrate
CFAMM00410838 CHEMBL2171324 Bioactive 6-[2-methoxy-4-[(E)-3-oxo-3-[6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexylamino]prop-1-enyl]phenoxy]hexyl nitrate
CFAMM00410837 CHEMBL2171327 Bioactive 4-[2-methoxy-4-[(E)-3-oxo-3-[8-(1,2,3,4-tetrahydroacridin-9-ylamino)octylamino]prop-1-enyl]phenoxy]butyl nitrate
CFAMM00410836 CHEMBL2171321 Bioactive 2-[2-methoxy-4-[(E)-3-oxo-3-[6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexylamino]prop-1-enyl]phenoxy]ethyl nitrate

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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