CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1167
Family Name Pol polyprotein inhibitor Hydroxyethylene deriv. 12 family
No. of Seeds 13 No. of Other Members 10
Family Centroid CFAMM00320273 Functional Category Bioactive
Superfamily Pol polyprotein and Integrin beta-3 Binder Superfamily
Class Class 716

Cousin Family NamesSeedsMembers
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand be... 4 301
HIV protease Inhibitor Saquinavir Family 64 428
Parathyroid hormone/parathyroid hormone-related peptide recept... 55 256
Somatostatin receptor type 2 ligand octapeptide Octreotide Family 27 172
Insulin receptor Ligand Insulin, Porcine Family 61 205
HIV-1 protease Inhibitor Atazanavir Family 16 58
Insulin-degrading enzyme inhibitor cyclic polypeptide Bacitrac... 30 259
Renin Inhibitor Remikiren Family 100 126
Histamine H1 receptor Ligand Mizolastine Family 14 603
Growth hormone receptor Ligand EP-51216 Family 34 390
NS5A protein Inhibitor Bms 790052 Family 5 9
BIBT986 family 7 96
Gastrin/cholecystokinin type B receptor Ligand PD136450 Family 53 117
Renin Inhibitor Enalkiren Family 56 44
Renin Inhibitor (h-261)boc-his-pro-phe-his-leu(oh)-val-ile-his... 33 41
Integrin alpha-V and Integrin beta-3 Inhibitor SB-223245 Family 27 36
Cathepsin B and Cathepsin K Inhibitor Z-ala-leu-his-agly-ile-v... 3 2
Renin Inhibitor Sul-pro-phe-n-mehis-lva-ile-amp Family 47 54
Glycylpeptide N-tetradecanoyltransferase Inhibitor SC-58272 Fa... 2 11
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 50 17
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
Type-1 angiotensin II receptor Ligand [sar1,tdf3]angii Family 135 2
Endothelin B receptor Ligand IRL-2500 Family 34 87
Melanocortin receptor Ligand Ac-his-dphe(3,4-dicl)-arg-trp-nh2... 10 14
Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7
Prothrombin and Cationic trypsin inhibitor (2S)-N-[(2S)-1-(1H-... 4 15
Pol polyprotein inhibitor penicillin deriv. 71 family 1 2
Pol polyprotein and Protease inhibitor 161186-52-3 family 3 3
Renin and Pepsin A inhibitor tert-butyl N-[(2S)-1-[[2-[[(4S,5S... 4 0
Pol polyprotein inhibitor AC1LAQE0 family 13 4
Integrin beta-3 and Integrin alpha-V inhibitor 2-[1-[2-[[4-(1H... 6 2
Pol polyprotein inhibitor N-[(2S)-1-[[(2S,3R,4S,5S)-3,4-dihydr... 2 0
Pol polyprotein inhibitor (2S)-4-(1H-benzimidazol-2-ylmethyl)-... 1 0
Pol polyprotein inhibitor AC1LA3L0 family 3 2
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 4 53
C-C chemokine receptor type 5 ligand SureCN1573831 family 4 3
Renin inhibitor propan-2-yl (3R)-2-hydroxy-3-[[(2S)-3-(1H-imid... 4 0
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 3 0
Renin and Cathepsin D inhibitor tert-butyl N-[(2S)-1-[[(2S)-1-... 2 2
Pol polyprotein inhibitor N-[(3R,4R,5R)-5-[[(2S)-1-(1H-benzimi... 5 4
Pol polyprotein inhibitor propan-2-yl N-[(2S)-1-[[(2S,3S,5R)-3... 6 2
C-C chemokine receptor type 5 ligand AC1MHRXO family 5 1
Renin inhibitor tert-butyl N-[(2S)-1-[[(2S)-1-[[(2S,3S,5S)-5-(... 2 0
Integrin beta-1 and Integrin alpha-4 inhibitor (5R)-5-[[(2R)-2... 2 3
Disintegrin and metalloproteinase domain-containing protein 17... 10 4
Integrin beta-3 and Integrin alpha-V inhibitor 2-[1-[2-[[4-(1H... 2 8
Matrilysin and Stromelysin-1 inhibitor (2R)-N-[(1S)-1-(1H-benz... 3 0
Renin inhibitor tert-butyl N-[(2S)-1-[[(2S)-1-[[(1R,2S)-3-cycl... 3 0
Pol polyprotein inhibitor AC1LABTQ family 4 0
Pol polyprotein and Protease inhibitor 161186-51-2 family 5 0
Integrin beta-3 and Integrin alpha-V inhibitor (2S)-3-[4-[4-[(... 9 7
Pol polyprotein inhibitor AC1LALEN family 7 0
Renin inhibitor (2R)-2-benzyl-N-[(2S)-1-[[(2S,3R,4S)-1-cyclohe... 6 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 3
Melanocyte-stimulating hormone receptor and Melanocortin recep... 1 0
Pol polyprotein inhibitor AC1LAIVF family 2 1
Lysosomal Pro-X carboxypeptidase inhibitor 9H-fluoren-9-ylmeth... 1 1
Glucagon receptor ligand SureCN3913003 family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00320272 CHEMBL314510 Bioactive AC1L9R1B
CFAMM00320251 CHEMBL333600 Bioactive (2S)-2-[[1H-benzimidazol-2-ylmethyl(methyl)carbamoyl]amino]-N-[(2S,3R,4S,5S)-5-[[(2R)-2-[[1H-benzimidazol-2-ylmethyl(methyl)carbamoyl]amino]-3-methylbutanoyl]amino]-3,4-dihydroxy-1,6-diphenylhexan-2-yl]-3-methylbutanamide
CFAMM00320258 CHEMBL76289 Bioactive tert-butyl N-[(E,2S,3S,5R)-5-[[(2R,3R)-1-(1H-benzimidazol-2-ylmethylamino)-3-methyl-1-oxopentan-2-yl]carbamoyl]-3-hydroxy-1,8-diphenyloct-7-en-2-yl]carbamate
CFAMM00320271 CHEMBL288163 Bioactive (2R,6R)-N,N'-bis[(2S)-1-(1H-benzimidazol-2-ylmethylamino)-3-methyl-1-oxobutan-2-yl]-2,6-dibenzyl-4-hydroxyheptanediamide
CFAMM00320264 CHEMBL20172 Bioactive L-687,908
CFAMM00320255 CHEMBL112416 Bioactive (2S)-2-[[1H-benzimidazol-2-ylmethyl(methyl)carbamoyl]amino]-N-[(2S,3S,4R,5S)-5-[[(2R)-2-[[1H-benzimidazol-2-ylmethyl(methyl)carbamoyl]amino]-3-methylbutanoyl]amino]-3,4-dihydroxy-1,6-diphenylhexan-2-yl]-3-methylbutanamide
CFAMM00320254 CHEMBL97304 Bioactive (2S)-2-[3-(1H-benzimidazol-2-yl)propanoylamino]-N-[(2S,3S,4S,5S)-5-[[(2S)-2-[3-(1H-benzimidazol-2-yl)propanoylamino]-3,3-dimethylbutanoyl]amino]-4-hydroxy-3-(hydroxymethyl)-1,6-diphenylhexan-2-yl]-3,3-dimethylbutanamide
CFAMM00320253 CHEMBL318168 Bioactive 161186-50-1
CFAMM00320260 CHEMBL113355 Bioactive (2S)-2-[[1H-benzimidazol-2-ylmethyl(methyl)carbamoyl]amino]-N-[(2S,3R,4R,5S)-5-[[(2R)-2-[[1H-benzimidazol-2-ylmethyl(methyl)carbamoyl]amino]-3-methylbutanoyl]amino]-3,4-dihydroxy-1,6-diphenylhexan-2-yl]-3-methylbutanamide
CFAMM00320273 CHEMBL21024 Bioactive Hydroxyethylene deriv. 12
CFAMM00320252 CHEMBL276447 Bioactive AC1L9R1A
CFAMM00320266 CHEMBL94824 Bioactive AC1L9R1C
CFAMM00320259 CHEMBL40760 Bioactive (2R,6R)-N,N'-bis[(2S,3S)-1-(1H-benzimidazol-2-ylmethylamino)-3-methyl-1-oxopentan-2-yl]-2,6-dibenzyl-4-hydroxyheptanediamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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