CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11674
Family Name Eukaryotic initiation factor 4A-I inhibitor methyl (1R,2R,3S,3aR,8bS)-1,8b-dihydroxy-6,8-dimethoxy-3a-(4-methylphenyl)-3-phenyl-2,3-dihydro-1H-cyclopenta[b][1]benzofuran-2-carboxylate family
No. of Seeds 12 No. of Other Members 1
Family Centroid CFAMM00410966 Functional Category Bioactive
Superfamily NF-kappa-B Inhibitor Rocaglamide Superfamily
Class Class 2689

Cousin Family NamesSeedsMembers
Prostaglandin G/H synthase 2 Inhibitor Nabumetone Family 4 267
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor Mycophenola... 4 353
Heat shock protein 90, putative Inhibitor Cromoglicate Family 14 2827
D-alanyl-D-alanine carboxypeptidase Inhibitor B-lactams Family 59 1364
Hidrosmin family 14 61
Ipriflavone family 62 2480
Rotenone family 16 107
Chromomycin A3 family 7 14
DNA topoisomerase 2-beta Inhibitor TOP-53 Family 2 12
Free fatty acid receptor 1 Ligand TAK-875 Family 2 54
Endothelin-1 receptor Ligand PD156707 Family 41 211
Oestrogen receptor and Estrogen receptor beta Ligand 3,8-dihyd... 20 57
Cannabinoid receptor 2 Ligand 2-(2-methoxybenzyl)-3h-benzo[f]c... 6 32
Cytochrome P450 3A4 Inhibitor (-)-cubebininolide Family 4 28
NF-kappa-B Inhibitor Rocaglamide Family 8 8
Protein farnesyltransferase subunit beta Inhibitor Cylindrol A... 3 43
Androgen receptor Ligand Palodesangren E Family 12 43
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 6 6
Squalene synthase inhibitor (6R,7R)-1-[(4S,5R)-4-acetyloxy-5-m... 8 5
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 4
Endothelin-1 receptor ligand SureCN8117947 family 1 3
Protein kinase C alpha type inhibitor [2-(hydroxymethyl)-5-oxo... 2 4
Protein kinase C beta type and Protein kinase C eta type inhib... 1 0
Protein kinase C alpha type inhibitor [(1R)-4-dodecoxy-1-(hydr... 1 18
Survival motor neuron protein and Prelamin-A/C inhibitor CHEMB... 2 32
Prenol Lipids Metabolite Austalide A Family 5 4
Prenol Lipids Metabolite 13-Hydroxydihydromelleolide Family 3 0


External ID

Functional Category

Molecule Name

CFAMM00410968 CHEMBL2170556 Bioactive methyl (1R,2R,3S,3aR,8bS)-6-cyano-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-3-phenyl-2,3-dihydro-1H-cyclopenta[b][1]benzofuran-2-carboxylate
CFAMM00410978 CHEMBL2170713 Bioactive dimethyl (1R,2R,3S,3aR,8bS)-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-3-phenyl-2,3-dihydro-1H-cyclopenta[b][1]benzofuran-2,6-dicarboxylate
CFAMM00410967 CHEMBL2170559 Bioactive methyl (1R,2R,3S,3aR,8bS)-3a-(4-cyanophenyl)-1,8b-dihydroxy-6,8-dimethoxy-3-phenyl-2,3-dihydro-1H-cyclopenta[b][1]benzofuran-2-carboxylate
CFAMM00410977 CHEMBL2170714 Bioactive methyl (1R,2R,3S,3aR,8bS)-1,8b-dihydroxy-6-[[(2S,3R,6S)-6-(2-hydroxyethyl)-3-methoxy-1,4-dioxan-2-yl]oxy]-8-methoxy-3a-(4-methoxyphenyl)-3-phenyl-2,3-dihydro-1H-cyclopenta[b][1]benzofuran-2-carboxylate
CFAMM00410966 CHEMBL2170558 Bioactive methyl (1R,2R,3S,3aR,8bS)-1,8b-dihydroxy-6,8-dimethoxy-3a-(4-methylphenyl)-3-phenyl-2,3-dihydro-1H-cyclopenta[b][1]benzofuran-2-carboxylate
CFAMM00410976 CHEMBL2170718 Bioactive methyl (1R,2R,3S,3aR,8bS)-1,8b-dihydroxy-6-[[(2S,3R,6S)-6-(hydroxymethyl)-3-methoxy-1,4-dioxan-2-yl]oxy]-8-methoxy-3a-(4-methoxyphenyl)-3-phenyl-2,3-dihydro-1H-cyclopenta[b][1]benzofuran-2-carboxylate
CFAMM00410964 CHEMBL2170722 Bioactive methyl (1R,2R,3S,3aR,8bS)-1,8b-dihydroxy-6-[[(2S,6S)-6-(hydroxymethyl)-1,4-dioxan-2-yl]oxy]-8-methoxy-3a-(4-methoxyphenyl)-3-phenyl-2,3-dihydro-1H-cyclopenta[b][1]benzofuran-2-carboxylate
CFAMM00410963 CHEMBL2170724 Bioactive methyl (1R,2R,3S,3aR,8bS)-1,6,8b-trihydroxy-8-methoxy-3a-(4-methoxyphenyl)-3-phenyl-2,3-dihydro-1H-cyclopenta[b][1]benzofuran-2-carboxylate
CFAMM00410971 CHEMBL2170555 Bioactive methyl (1R,2R,3S,3aR,8bS)-6-acetyl-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-3-phenyl-2,3-dihydro-1H-cyclopenta[b][1]benzofuran-2-carboxylate
CFAMM00410962 CHEMBL2170725 Bioactive methyl (1R,2R,3S,3aR,8bS)-6-[[(2S,6R)-6-[(1R)-1,2-dihydroxyethyl]-1,4-dioxan-2-yl]oxy]-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-3-phenyl-2,3-dihydro-1H-cyclopenta[b][1]benzofuran-2-carboxylate
CFAMM00410969 CHEMBL2170557 Bioactive methyl (1R,2R,3S,3aR,8bS)-6-chloro-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-3-phenyl-2,3-dihydro-1H-cyclopenta[b][1]benzofuran-2-carboxylate
CFAMM00410981 CHEMBL555196 Bioactive silvestrol

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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