CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11693
Family Name Eukaryotic translation initiation factor 2-alpha kinase 3 and Aurora kinase B inhibitor 1-[5-(4-amino-7-pyridin-3-ylthieno[3,2-c]pyridin-3-yl)-2,3-dihydroindol-1-yl]-2-phenylethanone family
No. of Seeds 5 No. of Other Members 0
Family Centroid CFAMM00212916 Functional Category Bioactive
Superfamily 5-hydroxytryptamine receptor and Muscarinic acetylcholine receptor M1 Binder Superfamily
Class Class 1642

Cousin Family NamesSeedsMembers
Aurora kinase A Inhibitor ABT-348 Family 20 49
5-hydroxytryptamine receptor Ligand Sl65.0472 Family 2 16
Vascular endothelial growth factor receptor 2 Ligand 3-(4-amin... 2 5
Poly [ADP-ribose] polymerase 1 Inhibitor N-(4-phenylthiazol-2-... 6 150
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 4 22
Substance-K receptor ligand 6-methyl-N-[1-[[(2S)-1-phenyl-5-(4... 3 9
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Receptor tyrosine-protein kinase erbB-2 ligand AGN-PC-07ZDR2 f... 7 33
Vascular endothelial growth factor receptor 2 and Mast/stem ce... 10 27
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor lig... 2 8
Serine/threonine-protein kinase Chk1 inhibitor SureCN3070314 f... 16 32
Gonadotropin-releasing hormone receptor ligand 1-[4-[1-[(2,6-d... 8 0
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 7 21
Mitogen-activated protein kinase 14 inhibitor N-[4-[2-ETHYL-4-... 4 5
Vascular endothelial growth factor receptor 2 and Platelet-der... 3 3
Vascular endothelial growth factor receptor 1 and Receptor-typ... 1 0
Protein kinase C zeta type and Inhibitor of nuclear factor kap... 1 6
Orexin receptor type 2 and Orexin receptor type 1 ligand (2-me... 3 1
Cell division cycle 7-related protein kinase and Protein DBF4 ... 2 1
Melanin-concentrating hormone receptor 1 and Muscarinic acetyl... 8 2
D(3) dopamine receptor and D(2) dopamine receptor ligand [4-[2... 6 5
Eukaryotic translation initiation factor 2-alpha kinase 3 inhi... 2 1
Eukaryotic translation initiation factor 2-alpha kinase 3 inhi... 1 0
Protein-cysteine N-palmitoyltransferase porcupine inhibitor 2-... 5 2
NAD-dependent protein deacetylase sirtuin-2 and NAD-dependent ... 8 12
Transient receptor potential cation channel subfamily V member... 1 0
Epidermal growth factor receptor and Vascular endothelial grow... 7 0
Vascular endothelial growth factor receptor 2 ligand Thienopyr... 2 2
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-00A4QJ family 12 6


External ID

Functional Category

Molecule Name

CFAMM00411128 CHEMBL2171129 Bioactive 1-[5-(4-amino-7-pyridin-4-ylthieno[3,2-c]pyridin-3-yl)-2,3-dihydroindol-1-yl]-2-phenylethanone
CFAMM00411127 CHEMBL2315069 Bioactive N-[3-(4-amino-7-pyridin-3-ylthieno[3,2-c]pyridin-3-yl)phenyl]-3-(trifluoromethyl)benzamide
CFAMM00411126 CHEMBL2171130 Bioactive 1-[5-(4-amino-7-piperidin-4-ylthieno[3,2-c]pyridin-3-yl)-2,3-dihydroindol-1-yl]-2-phenylethanone
CFAMM00411125 CHEMBL2171134 Bioactive 1-[5-(4-aminothieno[3,2-c]pyridin-3-yl)-2,3-dihydroindol-1-yl]-2-(2,5-difluorophenyl)ethanone

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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