CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11706
Family Name Leucine-rich repeat serine/threonine-protein kinase 2 inhibitor 5-chloro-2-N-[2-(difluoromethoxy)phenyl]-4-N-methylpyrimidine-2,4-diamine family
No. of Seeds 1 No. of Other Members 0
Family Centroid CFAMM00411272 Functional Category Bioactive
Superfamily Tyrosine-protein kinase JAK2 Inhibitor TG101348 Superfamily
Class Class 1144

Cousin Family NamesSeedsMembers
Peptide deformylase, mitochondrial Inhibitor Trimethoprim Family 67 482
Serine/threonine-protein kinase Chk1 and Serine/threonine-prot... 23 121
AP26113 family 16 90
SB1518 family 7 103
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Platelet-derived growth factor receptor alpha and Fibroblast g... 3 47
Reverse transcriptase Inhibitor UK-129485 Family 23 221
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
5-hydroxytryptamine receptor 1A Ligand CP-293019 Family 9 24
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 3
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Dihydrofolate reductase inhibitor AC1LA5HU family 8 4
Dihydrofolate reductase inhibitor AC1L9XPA family 6 5
Inositol monophosphatase 1 inhibitor CHEMBL1588383 family 1 6
ALK tyrosine kinase receptor and Insulin receptor ligand SureC... 7 1
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
Ephrin type-B receptor 4 and Vascular endothelial growth facto... 2 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 2
Vascular endothelial growth factor receptor 2 ligand urea deri... 2 1
ALK tyrosine kinase receptor ligand CHEMBL1946804 family 3 0
Wee1-like protein kinase and ALK tyrosine kinase receptor liga... 1 9
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Dihydrofolate reductase inhibitor AC1LAPW3 family 3 0
Dihydrofolate reductase inhibitor AGN-PC-001U7R family 3 0
Dihydrofolate reductase and Dihydrofolate reductase type 1 inh... 8 1
Cyclin-dependent kinase 4 and Cyclin-dependent kinase 2 inhibi... 1 3


External ID

Functional Category

Molecule Name

CFAMM00411272 CHEMBL2171740 Bioactive 5-chloro-2-N-[2-(difluoromethoxy)phenyl]-4-N-methylpyrimidine-2,4-diamine

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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