CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11707
Family Name Leucine-rich repeat serine/threonine-protein kinase 2 inhibitor [4-[[5-chloro-4-(methylamino)pyrimidin-2-yl]amino]-3-methylphenyl]-morpholin-4-ylmethanone family
No. of Seeds 2 No. of Other Members 0
Family Centroid CFAMM00411273 Functional Category Bioactive
Superfamily Mast/stem cell growth factor receptor Kit and Abelson tyrosine-protein kinase 2 Inhibitor Imatinib Superfamily
Class Class 144

Cousin Family NamesSeedsMembers
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Reverse transcriptase Inhibitor Nevirapine Family 23 640
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
Serine/threonine-protein kinase mTOR Inhibitor AZD2014 Family 2 41
GDC-0349 family 44 77
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 37 10
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
JAK Inhibitor Momelotinib Family 33 83
XL-888 family 16 85
Bacterial outer membrane Inhibitor HKI-9924129 Family 19 85
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
Bifunctional epoxide hydrolase 2 Inhibitor 6-amino-n-(2,4-dich... 10 116
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Sodium channel protein type 10 subunit alpha Ligand N-benzyl-5... 11 46
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 12
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 6 9
Coagulation factor X inhibitor AGN-PC-075AY8 family 28 21
Mitogen-activated protein kinase 1 and Cytochrome P450 3A4 inh... 1 0
Peroxisome proliferator-activated receptor gamma ligand 1-[(4-... 7 29
Metabotropic glutamate receptor 2 ligand AGN-PC-09QJ9P family 2 7
Hepatocyte growth factor receptor and Insulin receptor ligand ... 4 15
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[(E... 1 0
Coagulation factor X and Prothrombin inhibitor 2-carboxyindole... 2 8
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 1
Mitogen-activated protein kinase 14 inhibitor SureCN3305171 fa... 1 0
Transient receptor potential cation channel subfamily V member... 2 1
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 3 4
ALK tyrosine kinase receptor and Insulin receptor ligand 2-[[5... 1 0
Aurora kinase A and Aurora kinase B inhibitor 4-fluoro-N-[4-[(... 6 1
Aurora kinase A inhibitor Bisanilinopyrimidine, 6j family 2 1
Cathepsin K and Cathepsin S inhibitor 2-Cyano-pyrimidine, 17d ... 5 9
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 5 0
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (4-am... 2 1
Serine/threonine-protein kinase mTOR inhibitor 2-[4-[4-[(3S)-3... 3 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 0
Non-receptor tyrosine-protein kinase TYK2 ligand AGN-PC-0D0YSZ... 10 0
Coagulation factor X inhibitor AGN-PC-078Y0S family 7 1
Coagulation factor X inhibitor AGN-PC-078Y0T family 11 0
Epidermal growth factor receptor ligand AGN-PC-073LJS family 4 0
Mast/stem cell growth factor receptor Kit and Tyrosine-protein... 4 1
Melanin-concentrating hormone receptor 1 and Alpha-2A adrenerg... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00411274 CHEMBL2178129 Bioactive [5-chloro-2-methyl-4-[[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]phenyl]-morpholin-4-ylmethanone
CFAMM00411273 CHEMBL2171741 Bioactive [4-[[5-chloro-4-(methylamino)pyrimidin-2-yl]amino]-3-methylphenyl]-morpholin-4-ylmethanone

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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