CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11727
Family Name ALK tyrosine kinase receptor ligand 4-fluoro-N-[6-(piperidin-1-ylmethyl)-1-[4-(propan-2-ylcarbamoyl)cyclohexyl]benzimidazol-2-yl]benzamide family
No. of Seeds 10 No. of Other Members 7
Family Centroid CFAMM00411443 Functional Category Bioactive with Natural Product
Superfamily ALK tyrosine kinase receptor and Histone deacetylase 1 Binder Superfamily
Class Class 950

Cousin Family NamesSeedsMembers
Mu-type opioid receptor Ligand Fentanyl Family 9 647
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 10 157
Alpha adrenergic receptor Ligand Droperidol Family 20 244
Sodium channel protein type 5 subunit alpha Ligand Procainamid... 7 291
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 43 161
5-hydroxytryptamine 2 receptor Ligand Ketanserin Family 10 253
Androgen receptor Ligand Enzalutamide Family 1 4
Motilin receptor Ligand GSK962040 Family 30 457
Pan-DAC Inhibitor AR-42 Family 21 153
Dual specificity mitogen-activated protein kinase kinase Inhib... 7 69
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Integrin alpha-4 Inhibitor BIO-1211 Family 16 83
Vasopressin V2 receptor Ligand FR161282 Family 17 83
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
Cholecystokinin receptor type A Ligand VL-1499 Family 12 133
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 3 26
Phospholipase D1 Inhibitor Halopemide Family 17 111
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
D(2) dopamine receptor Ligand PD-168077 Family 6 5
Vasopressin V1a receptor ligand AGN-PC-074VJP family 3 1
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04UEDE family 7 17
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-07ZFJZ family 1 3
C-C chemokine receptor type 3 ligand 4-[(3-acetylphenyl)carbam... 3 4
Lethal factor inhibitor (2R)-2-(4-fluoro-3,5-dimethylanilino)-... 11 8
C-C chemokine receptor type 3 ligand SureCN6703027 family 2 1
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 53
Hypoxia-inducible factor 1-alpha and Ubiquitin carboxyl-termin... 1 1
Prelamin-A/C and Lysine-specific demethylase 4E inhibitor 4-(4... 2 3
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 6
Ectonucleotide pyrophosphatase/phosphodiesterase family member... 1 1
C-C chemokine receptor type 3 and Sodium-dependent serotonin t... 12 2
Furin inhibitor N-[(2S)-1-[[(2S)-1-[[(2S)-1-(4-carbamimidoylan... 3 16
D(2) dopamine receptor and Potassium voltage-gated channel sub... 1 1
Calcitonin gene-related peptide type 1 receptor and Cytochrome... 2 17
Microsomal triglyceride transfer protein large subunit inhibit... 8 1
ALK tyrosine kinase receptor and Leukocyte tyrosine kinase rec... 12 2
ALK tyrosine kinase receptor ligand 4-fluoro-N-[6-[[(2-hydroxy... 6 2
ALK tyrosine kinase receptor ligand methyl 4-[2-benzamido-6-(p... 2 0
C-C chemokine receptor type 3 ligand 1-(3-acetylphenyl)-3-[3-[... 9 1
Phospholipase D1 and Phospholipase D2 inhibitor 4-bromo-N-[(2S... 1 2
Proteinase-activated receptor 1 ligand 2-[[2-[[2-[acetyl-[(E)-... 6 15
Vascular endothelial growth factor receptor 2 ligand isoindoli... 1 0
Phospholipase D1 and Phospholipase D2 inhibitor N-[(2S)-1-[4-(... 4 0
Phospholipase D1 and Phospholipase D2 inhibitor N-[(2S)-1-[4-(... 3 5
Neuropeptide Y receptor type 5 ligand AGN-PC-01NRZK family 3 0
Beta-lactamase inhibitor (1R,5S)-4-[(4-carbamoylphenyl)carbamo... 3 2
Tyrosine-protein kinase ITK/TSK and Mast/stem cell growth fact... 1 0
Histone deacetylase 3 and Nuclear receptor corepressor 1 ligan... 7 4
Histone deacetylase 1 inhibitor N-(2-aminophenyl)-4-[[[4-(cycl... 5 3
Aldose reductase inhibitor (4R)-6-fluoro-3-methylspiro[1H-quin... 4 16


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00411451 CHEMBL2172328 Bioactive N-[6-(piperidin-1-ylmethyl)-1-[4-(propan-2-ylcarbamoyl)cyclohexyl]benzimidazol-2-yl]benzamide
CFAMM00411444 CHEMBL2172331 Bioactive N-[6-[(1,1-dioxo-1,4-thiazinan-4-yl)methyl]-1-[4-(propan-2-ylcarbamoyl)cyclohexyl]benzimidazol-2-yl]-4-fluorobenzamide
CFAMM00411450 CHEMBL2172329 Bioactive 4-fluoro-N-[1-[4-(propan-2-ylcarbamoyl)cyclohexyl]benzimidazol-2-yl]benzamide
CFAMM00411443 CHEMBL2172330 Bioactive 4-fluoro-N-[6-(piperidin-1-ylmethyl)-1-[4-(propan-2-ylcarbamoyl)cyclohexyl]benzimidazol-2-yl]benzamide
CFAMM00411442 CHEMBL2172335 Bioactive N-[6-[[4-(aminomethyl)piperidin-1-yl]methyl]-1-[4-(propan-2-ylcarbamoyl)cyclohexyl]benzimidazol-2-yl]-4-fluorobenzamide
CFAMM00411441 CHEMBL2172334 Bioactive 4-fluoro-N-[6-[(3-oxopiperazin-1-yl)methyl]-1-[4-(propan-2-ylcarbamoyl)cyclohexyl]benzimidazol-2-yl]benzamide
CFAMM00411454 CHEMBL2172325 Bioactive N-[1-[4-(ethylcarbamoyl)cyclohexyl]-6-(piperidin-1-ylmethyl)benzimidazol-2-yl]benzamide
CFAMM00411453 CHEMBL2172306 Bioactive 1-[[2-[(4-fluorobenzoyl)amino]-3-[4-(propan-2-ylcarbamoyl)cyclohexyl]benzimidazol-5-yl]methyl]piperidine-4-carboxamide
CFAMM00411452 CHEMBL2172307 Bioactive (2S)-1-[[2-[(4-fluorobenzoyl)amino]-3-[4-(propan-2-ylcarbamoyl)cyclohexyl]benzimidazol-5-yl]methyl]pyrrolidine-2-carboxamide
CFAMM00411445 CHEMBL2172333 Bioactive 4-fluoro-N-[6-(piperazin-1-ylmethyl)-1-[4-(propan-2-ylcarbamoyl)cyclohexyl]benzimidazol-2-yl]benzamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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