CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11728
Family Name ALK tyrosine kinase receptor ligand N-[6-[[4-(2-hydroxypropan-2-yl)piperidin-1-yl]methyl]-1-[4-(propan-2-ylcarbamoyl)cyclohexyl]benzimidazol-2-yl]pyridine-4-carboxamide family
No. of Seeds 2 No. of Other Members 0
Family Centroid CFAMM00411456 Functional Category Bioactive
Superfamily Oxytocin receptor and Histamine H3 receptor Binder Superfamily
Class Class 1006

Cousin Family NamesSeedsMembers
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand be... 4 301
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Reverse transcriptase Inhibitor Nevirapine Family 23 640
Prothrombin Inhibitor Dabigatran Family 7 182
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Mast/stem cell growth factor receptor Kit and Vascular endothe... 4 47
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
D(3) dopamine receptor Ligand SB-277011 Family 13 178
BIBT986 family 7 96
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
JAK Inhibitor Momelotinib Family 33 83
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
XL-888 family 16 85
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
C-C chemokine receptor type 5 Ligand GT-1282 Family 21 14
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
Calcitonin gene-related peptide type 1 receptor Ligand Isomer ... 30 31
Hydroxycarboxylic acid receptor 2 Ligand 2-(6-phenylhexyl)pyri... 4 11
Bifunctional epoxide hydrolase 2 Inhibitor 6-amino-n-(2,4-dich... 10 116
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 3 29
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Metabotropic glutamate receptor 5 Ligand 3-cyano-5-fluoro-n-(p... 2 9
Dipeptidyl peptidase 4 inhibitor (1S,3S,5S)-2-[(2S)-2-amino-2-... 3 5
Histamine H3 receptor ligand 1-[1-[1-[(2-aminopyridin-4-yl)met... 16 9
Adenosine receptor A2a ligand AGN-PC-01LVXW family 2 25
Adenosine receptor A2a ligand SureCN14156209 family 3 2
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-09M45... 8 1
Cell division cycle 7-related protein kinase inhibitor pyrrolo... 4 10
Cellular tumor antigen p53 inhibitor CHEMBL1418224 family 1 62
Peroxisome proliferator-activated receptor gamma ligand 1-[(4-... 7 29
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 4 2
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 1
Cellular tumor antigen p53 inhibitor CHEMBL1551403 family 1 0
C-X-C chemokine receptor type 3 ligand SureCN13205646 family 4 0
Mitogen-activated protein kinase 14 inhibitor N-ethyl-5-methyl... 17 3
Histamine H3 receptor and Potassium voltage-gated channel subf... 7 1
MAP kinase-activated protein kinase 2 inhibitor 4-fluoro-N-[4-... 25 1
Ribosomal protein S6 kinase alpha-3 inhibitor N-(3-ethylimidaz... 2 2
Mast/stem cell growth factor receptor Kit and Mitogen-activate... 4 2
Aurora kinase B and Aurora kinase A inhibitor 4-amino-N-[3-[[(... 5 3
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 8 5
Protein kinase C theta type inhibitor (2-aminopyridin-3-yl)-[6... 4 1
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
Substance-P receptor ligand Netupitant family 5 2
Aurora kinase A and Aurora kinase B inhibitor 4-fluoro-N-[4-[(... 6 1
Cathepsin K and Cathepsin S inhibitor 2-Cyano-pyrimidine, 17d ... 5 9
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 0
Coagulation factor X inhibitor 3-chloro-N-[(1S,2S)-2-[[4-(2-ox... 22 3
Melanocortin receptor 4 ligand AGN-PC-076AMO family 17 8
Motilin receptor ligand SureCN2768052 family 3 0
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 0
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 3 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 7 2
Tyrosine-protein kinase ITK/TSK and Insulin receptor ligand AG... 5 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and Potassium ... 2 0
Melanin-concentrating hormone receptor 1 ligand SureCN3834858 ... 2 1
Macrophage colony-stimulating factor 1 receptor ligand SureCN1... 2 2
Poly [ADP-ribose] polymerase 1 and Poly [ADP-ribose] polymeras... 4 0
Histone deacetylase 1 inhibitor SureCN4538615 family 2 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00411456 CHEMBL2172316 Bioactive N-[6-[[4-(2-hydroxypropan-2-yl)piperidin-1-yl]methyl]-1-[4-(propan-2-ylcarbamoyl)cyclohexyl]benzimidazol-2-yl]pyridine-4-carboxamide
CFAMM00411455 CHEMBL2172318 Bioactive N-[6-[[4-(2-hydroxypropan-2-yl)piperidin-1-yl]methyl]-1-[4-(propan-2-ylcarbamoyl)cyclohexyl]benzimidazol-2-yl]pyridine-3-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26195 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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