CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM11747
Family Name Transient receptor potential cation channel subfamily V member 1 ligand 2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(4-fluoropiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide family
No. of Seeds 57 No. of Other Members 4
Family Centroid CFAMM00411574 Functional Category Bioactive
Superfamily Transient receptor potential cation channel subfamily V member 1 Binder Superfamily 6
Class Class 328

Cousin Family NamesSeedsMembers
Reverse transcriptase Inhibitor Nevirapine Family 23 640
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Mitogen-activated protein kinase 12 Inhibitor VX-702 Family 3 49
Cannabinoid receptor 1 Ligand AZD2207 Family 18 48
Mast/stem cell growth factor receptor Kit and Vascular endothe... 4 47
XL-888 family 16 85
Class II cytokine receptor Ligand IL-10 Family 7 45
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
D(2) dopamine receptor and D(3) dopamine receptor Ligand A-706... 4 20
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Calcitonin gene-related peptide type 1 receptor Ligand Isomer ... 30 31
Neuromedin-K receptor and Substance-P receptor ligand AGN-PC-0... 18 0
Transient receptor potential cation channel subfamily V member... 1 4
Serine/threonine-protein kinase D1 inhibitor SureCN1424142 family 13 8
Histamine H3 receptor ligand 1-[1-[1-[(2-aminopyridin-4-yl)met... 16 9
Prothrombin and Cationic trypsin inhibitor tert-butyl N-[(2R)-... 4 3
Cathepsin K and Potassium voltage-gated channel subfamily H me... 4 7
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 19
Tyrosine-protein kinase JAK2 and Potassium voltage-gated chann... 2 7
Mitogen-activated protein kinase 1 and Cytochrome P450 3A4 inh... 1 0
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 3 3
Coagulation factor X inhibitor (6S,8aS)-N-[(6-amino-2-methylpy... 1 1
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 18 5
MAP kinase-activated protein kinase 2 inhibitor 4-fluoro-N-[4-... 25 1
Mast/stem cell growth factor receptor Kit and Mitogen-activate... 4 2
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 8 5
Receptor activity-modifying protein 1 and Calcitonin gene-rela... 9 0
Substance-P receptor ligand 2-[3,5-bis(trifluoromethyl)phenyl]... 3 1
Substance-P receptor and Neuromedin-K receptor ligand 2-[3,5-b... 6 0
Substance-P receptor ligand Netupitant family 5 2
Melanin-concentrating hormone receptor 1 ligand 6-(4-chlorophe... 8 1
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 9 0
Succinate receptor 1 ligand N-[[4-(3-methylphenyl)phenyl]methy... 2 14
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1
Transient receptor potential cation channel subfamily V member... 2 0
Transient receptor potential cation channel subfamily V member... 2 4
Substance-P receptor and Neuromedin-K receptor ligand 2-[3,5-b... 4 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor SureC... 6 0
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-[6-[2-(trif... 1 0
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-[6-(3-methy... 2 5
Beta-secretase 1 inhibitor N-[(2S,3R)-3-amino-4-fluoro-1-pheny... 4 17
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor 6-... 1 0
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor (3R)-... 4 12
Corticosteroid 11-beta-dehydrogenase isozyme 1 and Corticoster... 2 0
Bifunctional epoxide hydrolase 2 and Cytochrome P450 2C9 inhib... 3 0
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 0
Histamine H3 receptor ligand [1-[(2-aminopyridin-4-yl)methyl]-... 7 0
Histamine H3 receptor ligand [1-[(2-aminopyridin-4-yl)methyl]-... 2 0
Eukaryotic translation initiation factor 2-alpha kinase 3 and ... 4 0
Transient receptor potential cation channel subfamily V member... 22 3
Prothrombin inhibitor SureCN6057665 family 2 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 7 2
Transient receptor potential cation channel subfamily V member... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00411630 CHEMBL2177440 Bioactive N-[[2-(4-benzylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
CFAMM00411617 CHEMBL2178076 Bioactive N-[[2-(butylamino)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
CFAMM00411584 CHEMBL2177416 Bioactive N-[[2-(3-tert-butyl-1-oxa-2,8-diazaspiro[4.5]dec-2-en-8-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
CFAMM00411597 CHEMBL2179151 Bioactive 2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[6-(trifluoromethyl)-2-[4-[4-(trifluoromethyl)phenyl]piperazin-1-yl]pyridin-3-yl]methyl]propanamide
CFAMM00411610 CHEMBL2177428 Bioactive SureCN2523086
CFAMM00411623 CHEMBL2177436 Bioactive (2R)-2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(4-phenylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
CFAMM00411577 CHEMBL2177403 Bioactive N-[[2-[4-(4-fluorobenzoyl)piperidin-1-yl]-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
CFAMM00411590 CHEMBL2177410 Bioactive 2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-[4-(methoxymethyl)piperidin-1-yl]-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
CFAMM00411603 CHEMBL2178062 Bioactive N-[[2-(diethylamino)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
CFAMM00411616 CHEMBL2178064 Bioactive N-[[2-(dibutylamino)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
CFAMM00411629 CHEMBL2177441 Bioactive 2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-[4-[(4-methylphenyl)methyl]piperidin-1-yl]-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
CFAMM00411583 CHEMBL2178063 Bioactive N-[[2-(dipropylamino)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
CFAMM00411596 CHEMBL2178067 Bioactive 2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-pyrrolidin-1-yl-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
CFAMM00411609 CHEMBL2178068 Bioactive (2S)-2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(2-methylpyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
CFAMM00411622 CHEMBL2177435 Bioactive (2S)-2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(4-phenylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
CFAMM00411576 CHEMBL2177400 Bioactive 2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-morpholin-4-yl-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
CFAMM00411589 CHEMBL2177413 Bioactive [1-[3-[[2-[3-fluoro-4-(methanesulfonamido)phenyl]propanoylamino]methyl]-6-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl] acetate
CFAMM00411602 CHEMBL2177429 Bioactive (2S)-2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
CFAMM00411615 CHEMBL2177423 Bioactive SureCN2526674
CFAMM00411628 CHEMBL2177433 Bioactive N-[[2-(3,5-dimethylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
CFAMM00411582 CHEMBL2177408 Bioactive 2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(4-methoxypiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
CFAMM00411595 CHEMBL2177427 Bioactive 2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(3-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
CFAMM00411608 CHEMBL2178065 Bioactive N-[[2-[butyl(methyl)amino]-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
CFAMM00411621 CHEMBL2177434 Bioactive AGN-PC-0CMHMU
CFAMM00411575 CHEMBL2177401 Bioactive N-[[2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
CFAMM00411588 CHEMBL2177412 Bioactive 2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(4-propan-2-yloxypiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
CFAMM00411614 CHEMBL2179149 Bioactive 2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-[4-(2-fluorophenyl)piperazin-1-yl]-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
CFAMM00411627 CHEMBL2177432 Bioactive N-[[2-(4,4-dimethylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
CFAMM00411581 CHEMBL2177409 Bioactive N-[[2-(4-ethoxypiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
CFAMM00411594 CHEMBL2177419 Bioactive N-[[2-(azocan-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
CFAMM00411607 CHEMBL2177425 Bioactive N-[[2-(3,6-dihydro-2H-pyridin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
CFAMM00411620 CHEMBL2178059 Bioactive N-[[2-[4-[(3,4-difluorophenyl)methyl]piperidin-1-yl]-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
CFAMM00411574 CHEMBL2177404 Bioactive 2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(4-fluoropiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
CFAMM00411587 CHEMBL2177415 Bioactive N-[[2-[4-[(dimethylamino)methyl]piperidin-1-yl]-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
CFAMM00411600 CHEMBL2177424 Bioactive (2S)-2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-piperidin-1-yl-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
CFAMM00411613 CHEMBL2179148 Bioactive 2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-[4-(4-methylphenyl)piperazin-1-yl]-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
CFAMM00411580 CHEMBL2177398 Bioactive 2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[6-(trifluoromethyl)-2-[4-[3-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]pyridin-3-yl]methyl]propanamide
CFAMM00411626 CHEMBL2177431 Bioactive N-[[2-(4-ethylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
CFAMM00411593 CHEMBL2177418 Bioactive N-[[2-(azepan-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
CFAMM00411606 CHEMBL2177426 Bioactive 2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(2-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
CFAMM00411619 CHEMBL2177439 Bioactive 2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-[4-(4-fluorophenyl)-3,6-dihydro-2H-pyridin-1-yl]-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
CFAMM00411632 CHEMBL2177108 Bioactive N-[[2-(4-anilinopiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
CFAMM00411573 CHEMBL2177405 Bioactive 2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[6-(trifluoromethyl)-2-[4-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl]methyl]propanamide
CFAMM00411586 CHEMBL2177414 Bioactive [1-[3-[[2-[3-fluoro-4-(methanesulfonamido)phenyl]propanoylamino]methyl]-6-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl] 2,2-dimethylpropanoate
CFAMM00411599 CHEMBL2179153 Bioactive 2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(4-pyridin-2-ylpiperazin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
CFAMM00411612 CHEMBL2179147 Bioactive 2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-[4-(3-methylphenyl)piperazin-1-yl]-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
CFAMM00411625 CHEMBL2177430 Bioactive (2R)-2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
CFAMM00411579 CHEMBL2177399 Bioactive N-[[2-(4-benzylpiperazin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
CFAMM00411605 CHEMBL2178066 Bioactive 2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(N-methylanilino)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
CFAMM00411618 CHEMBL2177438 Bioactive 2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-[4-(4-fluorophenyl)piperidin-1-yl]-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
CFAMM00411631 CHEMBL2179150 Bioactive 2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-[4-(4-fluorophenyl)piperazin-1-yl]-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
CFAMM00411585 CHEMBL2177417 Bioactive 2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(3-phenyl-1-oxa-2,8-diazaspiro[4.5]dec-2-en-8-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
CFAMM00411611 CHEMBL2179146 Bioactive 2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(4-phenylpiperazin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
CFAMM00411624 CHEMBL2177437 Bioactive 2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
CFAMM00411578 CHEMBL2177402 Bioactive N-[[2-[4-[(3,5-difluorophenyl)methyl]piperidin-1-yl]-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
CFAMM00411591 CHEMBL2177411 Bioactive N-[[2-(4-butoxypiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
CFAMM00411604 CHEMBL2177422 Bioactive N-[[2-(1,3-dihydroisoindol-2-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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